eF-site ID 6eg9-B PDB Code 6eg9 Chain B click to enlarge Title IRAK4 in complex with Ponatinib Classification TRANSFERASE/TRANSFERASE INHIBITOR Compound Interleukin-1 receptor-associated kinase 4 Source (IRAK4_HUMAN) Sequence B:  FHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGY VNNTTVAVKKLAAITTEELKQQFDQEIKVMAKCQHENLVE LLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHM RCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKI SDFVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLP AVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTS VEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTA Description Functional site 1) chain B residue 408 type sequence K description binding site for residue CO A 503 source : AC3 2) chain B residue 192 type sequence M description binding site for residue 0LI B 501 source : AC4 3) chain B residue 211 type sequence A description binding site for residue 0LI B 501 source : AC4 4) chain B residue 233 type sequence E description binding site for residue 0LI B 501 source : AC4 5) chain B residue 237 type sequence M description binding site for residue 0LI B 501 source : AC4 6) chain B residue 246 type sequence V description binding site for residue 0LI B 501 source : AC4 7) chain B residue 262 type sequence Y description binding site for residue 0LI B 501 source : AC4 8) chain B residue 263 type sequence V description binding site for residue 0LI B 501 source : AC4 9) chain B residue 264 type sequence Y description binding site for residue 0LI B 501 source : AC4 10) chain B residue 265 type sequence M description binding site for residue 0LI B 501 source : AC4 11) chain B residue 302 type sequence L description binding site for residue 0LI B 501 source : AC4 12) chain B residue 308 type sequence I description binding site for residue 0LI B 501 source : AC4 13) chain B residue 309 type sequence H description binding site for residue 0LI B 501 source : AC4 14) chain B residue 318 type sequence L description binding site for residue 0LI B 501 source : AC4 15) chain B residue 327 type sequence I description binding site for residue 0LI B 501 source : AC4 16) chain B residue 328 type sequence S description binding site for residue 0LI B 501 source : AC4 17) chain B residue 329 type sequence D description binding site for residue 0LI B 501 source : AC4 18) chain B residue 330 type sequence F description binding site for residue 0LI B 501 source : AC4 19) chain B residue 365 type sequence T description binding site for residue SO4 B 502 source : AC5 20) chain B residue 367 type sequence K description binding site for residue SO4 B 502 source : AC5 21) chain B residue 441 type sequence K description binding site for residue SO4 B 502 source : AC5 22) chain B residue 166 type sequence H description binding site for residue CO B 503 source : AC6 23) chain B residue 286 type sequence H description binding site for residue CO B 504 source : AC7 24) chain B residue 390 type sequence H description binding site for residue CO B 505 source : AC8 25) chain B residue 311 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI1 26) chain B residue 192 type BINDING sequence M description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 27) chain B residue 213 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 28) chain B residue 313 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 29) chain B residue 329 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI3

Display surface Download Links