eF-site ID 6ef1-ABCDEFGHIJKLMs
PDB Code 6ef1
Chain A, B, C, D, E, F, G, H, I, J, K, L, M, s
Title Yeast 26S proteasome bound to ubiquitinated substrate (5D motor state)
Classification MOTOR PROTEIN
Compound Proteasome subunit alpha type-1
Source (6EF1)
Sequence A:  DRHITIFSPEGRLYQVEYAFKATNQTNINSLAVRGKDCTV
VISQKKVPDKLLDPTTVSYIFCISRTIGMVVNGPIPDARN
AALRAKAEAAEFRYKYGYDMPCDVLAKRMANLSQIYTQRA
YMRPLGVILTFVSVDEELGPSIYKTDPAGYYVGYKATATG
PKQQEITTNLENHFKKSKIDHINEESWEKVVEFAITHMID
ALGTEFSKNDLEVGVATKDKFFTLSAENIEERLVAIAEQ
B:  MTDRYSFSLTTFSPSGKLGQIDYALTAVKQGVTSLGIKAT
NGVVIATEKKSSSPLAMSETLSKVSLLTPDIGAVYSGMGP
DYRVLVDKSRKVAHTSYKRIYGEYPPTKLLVSEVAKIMQE
ATQSGGVRPFGVSLLIAGHDEFNGFSLYQVDPSGSYFPWK
ATAIGKGSVAAKTFLEKRWNDELELEDAIHIALLTLKESV
EGEFNGDTIELAIIGDENPDLLGYTGIPTDKGPRFRKLTS
QEINDRLEAL
C:  SRTTIFSPEGRLYQVEYALESISHAGTAIGIMASDGIVLA
AERKVTSTLLEQDTSTEKLYKLNDKIAVAVAGLTADAEIL
INTARIHAQNYLKTYNEDIPVEILVRRLSDIKQGYTQHGG
LRPFGVSFIYAGYDDRYGYQLYTSNPSGNYTGWKAISVGA
NTSAAQTLLQMDYKDDMKVDDAIELALKTLSKTTDSSALT
YDRLEFATIRKGANDGEVYQKIFKPQEIKDILVKTGIT
D:  SIFSPDGHIFQVEYALEAVKRGTCAVGVKGKNCVVLGCER
RSTLKLQDTRITPSKVSKIDSHVVLSFSGLNADSRILIEK
ARVEAQSHRLTLEDPVTVEYLTRYVAGVQQRYTQSGGVRP
FGVSTLIAGFDPRDDEPKLYQTEPSGIYSSWSAQTIGRNS
KTVREFLEKNYDRKEPPATVEECVKLTVRSLLEVVQTGAK
NIEITVVKPDSDIVALSSEEINQYVTQIEQEKQE
E:  DRGVSTFSPEGRLFQVEYSLEAIKLGSTAIGIATKEGVVL
GVEKRATSPLLESDSIEKIVEIDRHIGCAMSGLTADARSM
IEHARTAAVTHNLYYDEDINVESLTQSVCDLALRFGEGAS
GEERLMSRPFGVALLIAGHDADDGYQLFHAEPSGTFYRYN
AKAIGSGSEGAQAELLNEWHSSLTLKEAELLVLKILKQVM
EEKLDENNAQLSCITKQDGFKIYDNEKTAELIKELKEKEA
AE
F:  FRNNYDGDTVTFSPTGRLFQVEYALEAIKQGSVTVGLRSN
THAVLVALKRNADELSSYQKKIIKCDEHMGLSLAGLAPDA
RVLSNYLRQQCNYSSLVFNRKLAVERAGHLLCDKAQKNTQ
SYGGRPYGVGLLIIGYDKSGAHLLEFQPSGNVTELYGTAI
GARSQGAKTYLERTLDTFIKIDGNPDELIKAGVEAISQSL
RDESLTVDNLSIAIVGKDTPFTIYDGEAVAKYI
G:  TGYDLSNSVFSPDGRNFQVEYAVKAVENGTTSIGIKCNDG
VVFAVEKLITSKLLVPQKNVKIQVVDRHIGCVYSGLIPDG
RHLVNRGREEAASFKKLYKTPIPIPAFADRLGQYVQAHTL
YNSVRPFGVSTIFGGVDKNGAHLYMLEPSGSYWGYKGAAT
GKGRQSAKAELEKLVDHHPEGLSAREAVKQAAKIIYLAHE
DNKEKDFELEISWCSLSETNGLHKFVKGDLLQEAIDFAQK
EIN
H:  SVTMMTVEEKPDVTYSDVGGCKDQIEKLREVVELPLLSPE
RFATLGIDPPKGILLYGPPGTGKTLCARAVANRTDATFIR
VIGSELVQKYVGEGARMVRELFEMARTKKACIIFFDEIDA
VGGADNEVQRTMLELITQLDGFDPRGNIKVMFATNRPNTL
DPALLRPGRIDRKVEFSLPDLEGRANIFRIHSKSMSVERG
IRWELISRLCPNSTGAELRSVCTEAGMFAIRARRKVATEK
DFLKAVDKVISGYK
I:  MVSVMKMDKSPTESYSDIGGLESQIQEIKESVELPLTHPE
LYEEMGIKPPKGVILYGAPGTGKTLLAKAVANQTSATFLR
IVGSELIQKYLGDGPRLCRQIFKVAGENAPSIVFIDEIDA
IGTKRYDSNSGGEREIQRTMLELLNQLDGFDDRGDVKVIM
ATNKIETLDPALIRPGRIDRKILFENPDLSTKKKILGIHT
SKMNLSEDVNLETLVTTKDDLSGADIQAMCTEAGLLALRE
RRMQVTAEDFKQAKERVMKNKVEENLEGLYL
J:  LVSLMMVEKVPDSTYDMVGGLTKQIKEIKEVIELPVKHPE
LFESLGIAQPKGVILYGPPGTGKTLLARAVAHHTDCKFIR
VSGAELVQKYIGEGSRMVRELFVMAREHAPSIIFMDEIDS
IGSTRVEGSGGGDSEVQRTMLELLNQLDGFETSKNIKIIM
ATNRLDILDPALLRPGRIDRKIEFPPPSVAARAEILRIHS
RKMNLTRGINLRKVAEKMNGCSGADVKGVCTEAGMYALRE
RRIHVTQEDFELAVGKVMNKNQETAISVAKLFK
K:  DSDSSISVMGENEKPDVTYADVGGLDMQKQEIREAVELPL
VQADLYEQIGIDPPRGVLLYGPPGTGKTMLVKAVANSTKA
AFIRVNGSEFVHKYLGEGPRMVRDVFRLARENAPSIIFID
EVDSIATKRFDAQTGSDREVQRILIELLTQMDGFDQSTNV
KVIMATNRADTLDPALLRPGRLDRKIEFPSLRDRRERRLI
FGTIASKMSLAPEADLDSLIIRNDSLSGAVIAAIMQEAGL
RAVRKNRYVILQSDLEEAYATQVKTDNTVDKFDFYK
L:  LVYNMTSFEQGEITFDGIGGLTEQIRELREVIELPLKNPE
IFQRVGIKPPKGVLLYGPPGTGKTLLAKAVAATIGANFIF
SPASGIVDKYIGESARIIREMFAYAKEHEPCIIFMDEVDA
IGTSADREIQRTLMELLTQMDGFDNLGQTKIIMATNRPDT
LDPALLRPGRLDRKVEIPLPNEAGRLEIFKIHTAKVKKTG
EFDFEAAVKMSDGFNGADIRNCATEAGFFAIRDDRDHINP
DDLMKAVRKVAEVKKLEGTIEYQK
M:  DEKPTETYSDVGGLDKQIEELVEAIVLPMKRADKFKDMGI
RAPKGALMYGPPGTGKTLLARACAAQTNATFLKLAAPQLV
QMYIGEGAKLVRDAFALAKEKAPTIIFIDELDAIGTKRFD
SEKSGDREVQRTMLELLNQLDGFSSDDRVKVLAATNRVDV
LDPALLRSGRLDRKIEFPLPSEDSRAQILQIHSRKMTTDD
DINWQELARSTDEFNGAQLKAVTVEAGMIALRNGQSSVKH
EDFVEGISEVQARKSKSVSFYA
s:  NENVSARLGGASIAV
Description


Functional site

1) chain H
residue 211
type
sequence V
description binding site for residue ATP H 501
source : AC1

2) chain H
residue 213
type
sequence G
description binding site for residue ATP H 501
source : AC1

3) chain H
residue 252
type
sequence P
description binding site for residue ATP H 501
source : AC1

4) chain H
residue 253
type
sequence G
description binding site for residue ATP H 501
source : AC1

5) chain H
residue 254
type
sequence T
description binding site for residue ATP H 501
source : AC1

6) chain H
residue 255
type
sequence G
description binding site for residue ATP H 501
source : AC1

7) chain H
residue 256
type
sequence K
description binding site for residue ATP H 501
source : AC1

8) chain H
residue 257
type
sequence T
description binding site for residue ATP H 501
source : AC1

9) chain H
residue 388
type
sequence I
description binding site for residue ATP H 501
source : AC1

10) chain H
residue 416
type
sequence G
description binding site for residue ATP H 501
source : AC1

11) chain H
residue 417
type
sequence A
description binding site for residue ATP H 501
source : AC1

12) chain H
residue 420
type
sequence R
description binding site for residue ATP H 501
source : AC1

13) chain I
residue 310
type
sequence L
description binding site for residue ATP H 501
source : AC1

14) chain I
residue 314
type
sequence D
description binding site for residue ATP H 501
source : AC1

15) chain I
residue 340
type
sequence R
description binding site for residue ATP H 501
source : AC1

16) chain I
residue 184
type
sequence I
description binding site for residue ATP I 501
source : AC2

17) chain I
residue 227
type
sequence T
description binding site for residue ATP I 501
source : AC2

18) chain I
residue 228
type
sequence G
description binding site for residue ATP I 501
source : AC2

19) chain I
residue 229
type
sequence K
description binding site for residue ATP I 501
source : AC2

20) chain I
residue 230
type
sequence T
description binding site for residue ATP I 501
source : AC2

21) chain I
residue 231
type
sequence L
description binding site for residue ATP I 501
source : AC2

22) chain I
residue 361
type
sequence I
description binding site for residue ATP I 501
source : AC2

23) chain I
residue 390
type
sequence A
description binding site for residue ATP I 501
source : AC2

24) chain I
residue 393
type
sequence Q
description binding site for residue ATP I 501
source : AC2

25) chain J
residue 273
type
sequence L
description binding site for residue ATP I 501
source : AC2

26) chain J
residue 277
type
sequence N
description binding site for residue ATP I 501
source : AC2

27) chain J
residue 309
type
sequence R
description binding site for residue ATP I 501
source : AC2

28) chain J
residue 149
type
sequence M
description binding site for residue ATP J 501
source : AC3

29) chain J
residue 150
type
sequence V
description binding site for residue ATP J 501
source : AC3

30) chain J
residue 151
type
sequence G
description binding site for residue ATP J 501
source : AC3

31) chain J
residue 191
type
sequence P
description binding site for residue ATP J 501
source : AC3

32) chain J
residue 192
type
sequence G
description binding site for residue ATP J 501
source : AC3

33) chain J
residue 193
type
sequence T
description binding site for residue ATP J 501
source : AC3

34) chain J
residue 194
type
sequence G
description binding site for residue ATP J 501
source : AC3

35) chain J
residue 195
type
sequence K
description binding site for residue ATP J 501
source : AC3

36) chain J
residue 196
type
sequence T
description binding site for residue ATP J 501
source : AC3

37) chain J
residue 355
type
sequence G
description binding site for residue ATP J 501
source : AC3

38) chain J
residue 356
type
sequence A
description binding site for residue ATP J 501
source : AC3

39) chain K
residue 330
type
sequence R
description binding site for residue ATP J 501
source : AC3

40) chain K
residue 173
type
sequence D
description binding site for residue ATP K 501
source : AC4

41) chain K
residue 174
type
sequence V
description binding site for residue ATP K 501
source : AC4

42) chain K
residue 214
type
sequence P
description binding site for residue ATP K 501
source : AC4

43) chain K
residue 215
type
sequence P
description binding site for residue ATP K 501
source : AC4

44) chain K
residue 216
type
sequence G
description binding site for residue ATP K 501
source : AC4

45) chain K
residue 217
type
sequence T
description binding site for residue ATP K 501
source : AC4

46) chain K
residue 218
type
sequence G
description binding site for residue ATP K 501
source : AC4

47) chain K
residue 219
type
sequence K
description binding site for residue ATP K 501
source : AC4

48) chain K
residue 220
type
sequence T
description binding site for residue ATP K 501
source : AC4

49) chain K
residue 221
type
sequence M
description binding site for residue ATP K 501
source : AC4

50) chain K
residue 352
type
sequence I
description binding site for residue ATP K 501
source : AC4

51) chain K
residue 380
type
sequence G
description binding site for residue ATP K 501
source : AC4

52) chain K
residue 381
type
sequence A
description binding site for residue ATP K 501
source : AC4

53) chain L
residue 183
type
sequence I
description binding site for residue ADP L 501
source : AC5

54) chain L
residue 225
type
sequence G
description binding site for residue ADP L 501
source : AC5

55) chain L
residue 226
type
sequence T
description binding site for residue ADP L 501
source : AC5

56) chain L
residue 227
type
sequence G
description binding site for residue ADP L 501
source : AC5

57) chain L
residue 228
type
sequence K
description binding site for residue ADP L 501
source : AC5

58) chain L
residue 229
type
sequence T
description binding site for residue ADP L 501
source : AC5

59) chain L
residue 230
type
sequence L
description binding site for residue ADP L 501
source : AC5

60) chain L
residue 360
type
sequence I
description binding site for residue ADP L 501
source : AC5

61) chain L
residue 364
type
sequence H
description binding site for residue ADP L 501
source : AC5

62) chain L
residue 388
type
sequence G
description binding site for residue ADP L 501
source : AC5

63) chain L
residue 389
type
sequence A
description binding site for residue ADP L 501
source : AC5

64) chain L
residue 392
type
sequence R
description binding site for residue ADP L 501
source : AC5

65) chain M
residue 224
type
sequence P
description binding site for residue ADP M 501
source : AC6

66) chain M
residue 225
type
sequence G
description binding site for residue ADP M 501
source : AC6

67) chain M
residue 226
type
sequence T
description binding site for residue ADP M 501
source : AC6

68) chain M
residue 227
type
sequence G
description binding site for residue ADP M 501
source : AC6

69) chain M
residue 228
type
sequence K
description binding site for residue ADP M 501
source : AC6

70) chain M
residue 360
type
sequence I
description binding site for residue ADP M 501
source : AC6

71) chain M
residue 222
type BINDING
sequence G
description BINDING => ECO:0000255
source Swiss-Prot : SWS_FT_FI1

72) chain C
residue 199
type BINDING
sequence K
description BINDING => ECO:0000255
source Swiss-Prot : SWS_FT_FI1

73) chain C
residue 231
type BINDING
sequence K
description BINDING => ECO:0000255
source Swiss-Prot : SWS_FT_FI1

74) chain M
residue 180
type MOD_RES
sequence Y
description Phosphotyrosine => ECO:0007744|PubMed:19779198
source Swiss-Prot : SWS_FT_FI2

75) chain I
residue 255
type MOD_RES
sequence K
description Phosphotyrosine => ECO:0007744|PubMed:19779198
source Swiss-Prot : SWS_FT_FI2

76) chain I
residue 290
type MOD_RES
sequence K
description Phosphotyrosine => ECO:0007744|PubMed:19779198
source Swiss-Prot : SWS_FT_FI2

77) chain B
residue 5-27
type prosite
sequence YSFSLTTFSPSGKLGQIDYALTA
description PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YsfslTtFSPsGKlgQIDYAltA
source prosite : PS00388

78) chain F
residue 6-28
type prosite
sequence YDGDTVTFSPTGRLFQVEYALEA
description PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YsfslTtFSPsGKlgQIDYAltA
source prosite : PS00388

79) chain G
residue 8-30
type prosite
sequence YDLSNSVFSPDGRNFQVEYAVKA
description PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YsfslTtFSPsGKlgQIDYAltA
source prosite : PS00388

80) chain K
residue 312-330
type prosite
sequence VKVIMATNRADTLDPALLR
description AAA AAA-protein family signature. VkVImATNradtLDpALl.R
source prosite : PS00674

81) chain M
residue 321-339
type prosite
sequence VKVLAATNRVDVLDPALLR
description AAA AAA-protein family signature. VkVImATNradtLDpALl.R
source prosite : PS00674

82) chain J
residue 288-306
type prosite
sequence IKIIMATNRLDILDPALLR
description AAA AAA-protein family signature. VkVImATNradtLDpALl.R
source prosite : PS00674

83) chain H
residue 349-367
type prosite
sequence IKVMFATNRPNTLDPALLR
description AAA AAA-protein family signature. VkVImATNradtLDpALl.R
source prosite : PS00674

84) chain L
residue 321-339
type prosite
sequence TKIIMATNRPDTLDPALLR
description AAA AAA-protein family signature. VkVImATNradtLDpALl.R
source prosite : PS00674

85) chain I
residue 322-340
type prosite
sequence VKVIMATNKIETLDPALIR
description AAA AAA-protein family signature. VkVImATNradtLDpALl.R
source prosite : PS00674

86) chain D
residue 34-81
type prosite
sequence VGVKGKNCVVLGCERRSTLKLQDTRITPSKVSKIDSHVVL
SFSGLNAD
description PROTEASOME_BETA_1 Proteasome beta-type subunits signature. VGVkGknCVVLGCErrstlklqdtritps.KvskidshvvlsfsGlnAD
source prosite : PS00854

87) chain C
residue 36-83
type prosite
sequence IGIMASDGIVLAAERKVTSTLLEQDTSTEKLYKLNDKIAV
AVAGLTAD
description PROTEASOME_BETA_1 Proteasome beta-type subunits signature. VGVkGknCVVLGCErrstlklqdtritps.KvskidshvvlsfsGlnAD
source prosite : PS00854


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