eF-site ID 6ee1-D PDB Code 6ee1 Chain D click to enlarge Title Crystal structure of Mycobacterium tuberculosis ICL2 in complex with acetyl-CoA Classification LYASE Compound Isocitrate lyase 2 Source (ACEA2_MYCTO) Sequence D:  HTPFEQDFEKDVAATQRYFDSSRFAGIIRLYTARQVVEQR GTIPVDHIVAREAAGAFYERLRELFAARKSITTFGPYSPG QAVSMKRMGIEAIYLGGWATSAKGSSTEDPGPDLASYPLS QVPDDAAVLVRALLTADRNQHYLRLQMSERQRAATPAYDF RPFIIADADTGHGGDPHVRNLIRRFVEVGVPGYHIEDQRP GTKKCGGGKVLVPSDEQIKRLNAARFQLDIMRVPGIIVAR TDAEAANLIDSRADERDQPFLLGATKLDVPSYKSCFLAMV RRFYELGVKELNGHLLYALGDSEYAAAGGWLERQGIFGLV SDAVNAWREDQQSIDGIFDQVESRFVAAWEDDAGLMTYGE AVADVLEFAPEEWRAFAARASLHAARAKAKELGADPPWDC ELAKTPEGYYQIRGGIPYAIAKSLAAAPFADILWMETKTA DLADARQFAEAIHAEFPDQMLAYNLSPSFNWDTTGMTDEE MRRFPEELGKMGFVFNFITYGGHQIDGVAAEEFATALRQD GMLALARLQRKMRLVESPYRTPQTLVGGPRSDAALAASSG RTATTVQTEVPRKLLEEWLAMWSGHYQLKDKLRVQLRPQR AGSEVLELGIHGESDDKLANVIFQPIQDRRGRTILLVRDQ NTFGAELRQKRLMTLIHLWLVHRFKAQAVHYVTPTDDNLY QTSKMKSHGIFTEVNQEVGEIIVAEVNHPRIAELLTPDRV ALRKLITKEA Description Functional site 1) chain D residue 716 type sequence Y description binding site for residue ACO C 801 source : AC5 2) chain D residue 674 type sequence R description binding site for residue ACO D 801 source : AC7 3) chain D residue 675 type sequence D description binding site for residue ACO D 801 source : AC7 4) chain D residue 676 type sequence Q description binding site for residue ACO D 801 source : AC7 5) chain D residue 677 type sequence N description binding site for residue ACO D 801 source : AC7 6) chain D residue 678 type sequence T description binding site for residue ACO D 801 source : AC7 7) chain D residue 684 type sequence R description binding site for residue ACO D 801 source : AC7 8) chain D residue 685 type sequence Q description binding site for residue ACO D 801 source : AC7 9) chain D residue 686 type sequence K description binding site for residue ACO D 801 source : AC7 10) chain D residue 687 type sequence R description binding site for residue ACO D 801 source : AC7 11) chain D residue 689 type sequence M description binding site for residue ACO D 801 source : AC7 12) chain D residue 690 type sequence T description binding site for residue ACO D 801 source : AC7 13) chain D residue 708 type sequence V description binding site for residue ACO D 801 source : AC7 14) chain D residue 711 type sequence T description binding site for residue ACO D 801 source : AC7 15) chain D residue 713 type sequence D description binding site for residue ACO D 801 source : AC7 16) chain D residue 714 type sequence N description binding site for residue ACO D 801 source : AC7 17) chain D residue 716 type sequence Y description binding site for residue ACO D 801 source : AC7 18) chain D residue 717 type sequence Q description binding site for residue ACO D 801 source : AC7 19) chain D residue 720 type sequence K description binding site for residue ACO D 801 source : AC7 20) chain D residue 724 type sequence H description binding site for residue ACO D 801 source : AC7 21) chain D residue 764 type sequence K description binding site for residue ACO D 801 source : AC7 22) chain D residue 450 type sequence A description binding site for residue MG D 802 source : AC8 23) chain D residue 453 type sequence A description binding site for residue MG D 802 source : AC8 24) chain D residue 482 type sequence Q description binding site for residue MG D 802 source : AC8 25) chain D residue 215 type ACT_SITE sequence C description Proton acceptor => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI1 26) chain D residue 106 type BINDING sequence G description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2 27) chain D residue 177 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2 28) chain D residue 216 type BINDING sequence G description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2 29) chain D residue 252 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2 30) chain D residue 487 type BINDING sequence N description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2 31) chain D residue 522 type BINDING sequence T description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2

Display surface Download Links