eF-site ID 6ee1-C PDB Code 6ee1 Chain C click to enlarge Title Crystal structure of Mycobacterium tuberculosis ICL2 in complex with acetyl-CoA Classification LYASE Compound Isocitrate lyase 2 Source (ACEA2_MYCTO) Sequence C:  TPFEQDFEKDVAATQRYFDSSRFAGIIRLYTARQVVEQRG TIPVDHIVAREAAGAFYERLRELFAARKSITTFGPYSPGQ AVSMKRMGIEAIYLGGWATSAKGSSTEDPGPDLASYPLSQ VPDDAAVLVRALLTADRNQHYLRLQMSERQRAATPAYDFR PFIIADADTGHGGDPHVRNLIRRFVEVGVPGYHIEDQRPG TKKCGGGKVLVPSDEQIKRLNAARFQLDIMRVPGIIVART DAEAANLIDSRADERDQPFLLGALDVPSYKSCFLAMVRRF YELGVKELNGHLLYALGDSEYAAAGGWLERQGIFGLVSDA VNAWREDQSIDGIFDQVESRFVAAWEDDAGLMTYGEAVAD VLEMAPEEWRAFAARASLHAARAKAKELADPPWDCELAKT PEGYYQIRGGIPYAIAKSLAAAPFADILWMETKTADLADA RQFAEAIHAEFPDQMLAYNLSPSFNWDTTGMTDEEMRRFP EELGKMGFVFNFITYGGHQIDGVAAEEFATALRQDGMLAL ARLQRKMRLVESPYRTPQTLVGGPRSDAALAASSGRTATV QTEVPRKLLEEWLAMWSGHYQLKDKLRVQLRPQRAGSEVL ELGIHGESDDKLANVIFQPIQDRRGRTILLVRDQNTFGAE LRQKRLMTLIHLWLVHRFKAQAVHYVTPTDDNLYQTSKMK SHGIFTEVNQEVGEIIVAEVNHPRIAELLTPDRVALRKLI TK Description Functional site 1) chain C residue 673 type sequence V description binding site for residue ACO C 801 source : AC5 2) chain C residue 674 type sequence R description binding site for residue ACO C 801 source : AC5 3) chain C residue 675 type sequence D description binding site for residue ACO C 801 source : AC5 4) chain C residue 676 type sequence Q description binding site for residue ACO C 801 source : AC5 5) chain C residue 677 type sequence N description binding site for residue ACO C 801 source : AC5 6) chain C residue 678 type sequence T description binding site for residue ACO C 801 source : AC5 7) chain C residue 684 type sequence R description binding site for residue ACO C 801 source : AC5 8) chain C residue 685 type sequence Q description binding site for residue ACO C 801 source : AC5 9) chain C residue 686 type sequence K description binding site for residue ACO C 801 source : AC5 10) chain C residue 687 type sequence R description binding site for residue ACO C 801 source : AC5 11) chain C residue 688 type sequence L description binding site for residue ACO C 801 source : AC5 12) chain C residue 689 type sequence M description binding site for residue ACO C 801 source : AC5 13) chain C residue 690 type sequence T description binding site for residue ACO C 801 source : AC5 14) chain C residue 708 type sequence V description binding site for residue ACO C 801 source : AC5 15) chain C residue 711 type sequence T description binding site for residue ACO C 801 source : AC5 16) chain C residue 713 type sequence D description binding site for residue ACO C 801 source : AC5 17) chain C residue 714 type sequence N description binding site for residue ACO C 801 source : AC5 18) chain C residue 716 type sequence Y description binding site for residue ACO C 801 source : AC5 19) chain C residue 717 type sequence Q description binding site for residue ACO C 801 source : AC5 20) chain C residue 720 type sequence K description binding site for residue ACO C 801 source : AC5 21) chain C residue 724 type sequence H description binding site for residue ACO C 801 source : AC5 22) chain C residue 450 type sequence A description binding site for residue MG C 802 source : AC6 23) chain C residue 453 type sequence A description binding site for residue MG C 802 source : AC6 24) chain C residue 482 type sequence Q description binding site for residue MG C 802 source : AC6 25) chain C residue 215 type ACT_SITE sequence C description Proton acceptor => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI1 26) chain C residue 106 type BINDING sequence G description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2 27) chain C residue 177 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2 28) chain C residue 216 type BINDING sequence G description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2 29) chain C residue 252 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2 30) chain C residue 487 type BINDING sequence N description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2 31) chain C residue 522 type BINDING sequence T description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2

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