eF-site ID 6ee1-A PDB Code 6ee1 Chain A click to enlarge Title Crystal structure of Mycobacterium tuberculosis ICL2 in complex with acetyl-CoA Classification LYASE Compound Isocitrate lyase 2 Source (ACEA2_MYCTO) Sequence A:  TPFEQDFEKDVAATQRYFDSSRFAGIIRLYTARQVVEQRG TIPVDHIVAREAAGAFYERLRELFAARKSITTFGPYSPGQ AVSMKRMGIEAIYLGGWATSAKGSSTEDPGPDLASYPLSQ VPDDAAVLVRALLTADRNQHYLRLQMSERQRAATPAYDFR PFIIADADTGHGGDPHVRNLIRRFVEVGVPGYHIEDQRPG TKKCGGKVLVPSDEQIKRLNAARFQLDIMRVPGIIVARTD AEAANLIDSRADERDQPFLLGATKLDVPSYKSCFLAMVRR FYELGVKELNGHLLYALGDSEYAAAGGWLERQGIFGLVSD AVNAWREDGSIDGIFDQVESRFVAAWEDDAGLMTYGEAVA DVLEAPEEWRAFAARASLHAARAKAKELGDPPWDCELAKT PEGYYQIRGGIPYAIAKSLAAAPFADILWMETKTADLADA RQFAEAIHAEFPDQMLAYNLSPSFNWDTTGMTDEEMRRFP EELGKMGFVFNFITYGGHQIDGVAAEEFATALRQDGMLAL ARLQRKMRLVESPYRTPQTLVGGPRSDAALAASSGRTATV QTEVPRKLLEEWLAMWSGHYQLKLRVQLRPQRAGSEVLEL GIHGESDKLANVIFQPIQDRRGRTILLVRDQNTFGAELRQ KRLMTLIHLWLVHRFKAQAVHYVTPTDDNLYQTSKMKSHG IFTEVNQEVGEIIVAEVNHPRIAELLTPDRVALRKLITK Description Functional site 1) chain A residue 674 type sequence R description binding site for residue ACO A 801 source : AC1 2) chain A residue 675 type sequence D description binding site for residue ACO A 801 source : AC1 3) chain A residue 676 type sequence Q description binding site for residue ACO A 801 source : AC1 4) chain A residue 677 type sequence N description binding site for residue ACO A 801 source : AC1 5) chain A residue 678 type sequence T description binding site for residue ACO A 801 source : AC1 6) chain A residue 684 type sequence R description binding site for residue ACO A 801 source : AC1 7) chain A residue 685 type sequence Q description binding site for residue ACO A 801 source : AC1 8) chain A residue 686 type sequence K description binding site for residue ACO A 801 source : AC1 9) chain A residue 687 type sequence R description binding site for residue ACO A 801 source : AC1 10) chain A residue 689 type sequence M description binding site for residue ACO A 801 source : AC1 11) chain A residue 690 type sequence T description binding site for residue ACO A 801 source : AC1 12) chain A residue 708 type sequence V description binding site for residue ACO A 801 source : AC1 13) chain A residue 709 type sequence T description binding site for residue ACO A 801 source : AC1 14) chain A residue 711 type sequence T description binding site for residue ACO A 801 source : AC1 15) chain A residue 713 type sequence D description binding site for residue ACO A 801 source : AC1 16) chain A residue 714 type sequence N description binding site for residue ACO A 801 source : AC1 17) chain A residue 716 type sequence Y description binding site for residue ACO A 801 source : AC1 18) chain A residue 717 type sequence Q description binding site for residue ACO A 801 source : AC1 19) chain A residue 720 type sequence K description binding site for residue ACO A 801 source : AC1 20) chain A residue 724 type sequence H description binding site for residue ACO A 801 source : AC1 21) chain A residue 764 type sequence K description binding site for residue ACO A 801 source : AC1 22) chain A residue 450 type sequence A description binding site for residue MG A 802 source : AC2 23) chain A residue 453 type sequence A description binding site for residue MG A 802 source : AC2 24) chain A residue 482 type sequence Q description binding site for residue MG A 802 source : AC2 25) chain A residue 665 type sequence R description binding site for residue ACO C 801 source : AC5 26) chain A residue 215 type ACT_SITE sequence C description Proton acceptor => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI1 27) chain A residue 106 type BINDING sequence G description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2 28) chain A residue 177 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2 29) chain A residue 216 type BINDING sequence G description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2 30) chain A residue 252 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2 31) chain A residue 487 type BINDING sequence N description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2 32) chain A residue 522 type BINDING sequence T description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2

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