eF-site ID 6edz-D PDB Code 6edz Chain D click to enlarge Title Crystal structure of Mycobacterium tuberculosis ICL2 in complex with acetyl-CoA, form I Classification LYASE Compound Isocitrate lyase 2 Source (ACEA2_MYCTO) Sequence D:  HTPFEQDFEKDVAATQRYFDSSRFAGIIRLYTARQVVEQR GTIPVDHIVAREAAGAFYERLRELFAARKSITTFGPYSPG QAVSMKRMGIEAIYLGGWATSAKGSSTEDPGPDLASYPLS QVPDDAAVLVRALLTADRNQHYLRLQMSERQRAATPAYDF RPFIIADADTGHGGDPHVRNLIRRFVEVGVPGYHIEDQRP GTKKHQGGKVLVPSDEQIKRLNAARFQLDIMRVPGIIVAR TDAEAANLIDSRADERDQPFLLGATKLDVPSYKSCFLAMV RRFYELGVKELNGHLLYALGDSEYAAAGGWLERQGIFGLV SDAVNAWREDGQQSIDGIFDQVESRFVAAWEDDAGLMTYG EAVADVLEAPEEWRAFAARASLHAARAKAKELGADPPWDC ELAKTPEGYYQIRGGIPYAIAKSLAAAPFADILWMETKTA DLADARQFAEAIHAEFPDQMLAYNLSPSFNWDTTGMTDEE MRRFPEELGKMGFVFNFITYGGHQIDGVAAEEFATALRQD GMLALARLQRKMRLVESPYRTPQTLVGGPRSDAALAASSG RTATTKAMGVQTEVPRKLLEEWLAMWSGHYQLKDKLRVQL RPQRAGSEVLELGIHGESDDKLANVIFQPIQDRRGRTILL VRDQNTFGAELRQKRLMTLIHLWLVHRFKAQAVHYVTPTD DNLYQTSKMKSHGIFTEVNQEVGEIIVAEVNHPRIAELLT PDRVALRKLITKE Description (1)  Isocitrate lyase 2 (E.C.4.1.3.1) Functional site 1) chain D residue 716 type sequence Y description binding site for residue ACO C 801 source : AC3 2) chain D residue 673 type sequence V description binding site for residue ACO D 801 source : AC4 3) chain D residue 676 type sequence Q description binding site for residue ACO D 801 source : AC4 4) chain D residue 677 type sequence N description binding site for residue ACO D 801 source : AC4 5) chain D residue 678 type sequence T description binding site for residue ACO D 801 source : AC4 6) chain D residue 684 type sequence R description binding site for residue ACO D 801 source : AC4 7) chain D residue 685 type sequence Q description binding site for residue ACO D 801 source : AC4 8) chain D residue 686 type sequence K description binding site for residue ACO D 801 source : AC4 9) chain D residue 687 type sequence R description binding site for residue ACO D 801 source : AC4 10) chain D residue 689 type sequence M description binding site for residue ACO D 801 source : AC4 11) chain D residue 690 type sequence T description binding site for residue ACO D 801 source : AC4 12) chain D residue 708 type sequence V description binding site for residue ACO D 801 source : AC4 13) chain D residue 709 type sequence T description binding site for residue ACO D 801 source : AC4 14) chain D residue 710 type sequence P description binding site for residue ACO D 801 source : AC4 15) chain D residue 711 type sequence T description binding site for residue ACO D 801 source : AC4 16) chain D residue 713 type sequence D description binding site for residue ACO D 801 source : AC4 17) chain D residue 714 type sequence N description binding site for residue ACO D 801 source : AC4 18) chain D residue 716 type sequence Y description binding site for residue ACO D 801 source : AC4 19) chain D residue 717 type sequence Q description binding site for residue ACO D 801 source : AC4 20) chain D residue 720 type sequence K description binding site for residue ACO D 801 source : AC4 21) chain D residue 724 type sequence H description binding site for residue ACO D 801 source : AC4 22) chain D residue 764 type sequence K description binding site for residue ACO D 801 source : AC4 23) chain D residue 106 type BINDING sequence G description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2 24) chain D residue 177 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2 25) chain D residue 252 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2 26) chain D residue 487 type BINDING sequence N description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2 27) chain D residue 522 type BINDING sequence T description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2

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