eF-site ID 6edz-C PDB Code 6edz Chain C click to enlarge Title Crystal structure of Mycobacterium tuberculosis ICL2 in complex with acetyl-CoA, form I Classification LYASE Compound Isocitrate lyase 2 Source (ACEA2_MYCTO) Sequence C:  HTPFEQDFEKDVAATQRYFDSSRFAGIIRLYTARQVVEQR GTIPVDHIVAREAAGAFYERLRELFAARKSITTFGPYSPG QAVSMKRMGIEAIYLGGWATSAKGSSTEDPGPDLASYPLS QVPDDAAVLVRALLTADRNQHYLRLQMSERQRAATPAYDF RPFIIADADTGHGGDPHVRNLIRRFVEVGVPGYHIEDQRP GTKGKVLVPSDEQIKRLNAARFQLDIMRVPGIIVARTDAE AANLIDSRADERDQPFLLGAVPSYKSCFLAMVRRFYELGV KELNGHLLYALGDSEYAAAGGWLERQGIFGLVSDAVNAWR EDGQQSIDGIFDQVESRFVAAWEDDAGLMTYGEAVADVMA PEEWRAFAARASLHAARAKAKELGADPPWDCELAKTPEGY YQIRGGIPYAIAKSLAAAPFADILWMETKTADLADARQFA EAIHAEFPDQMLAYNLSPSFNWDTTGMTDEEMRRFPEELG KMGFVFNFITYGGHQIDGVAAEEFATALRQDGMLALARLQ RKMRLVESPYRTPQTLVGGPRSDAALAASSGRTATTKAMG VQTEVPRKLLEEWLAMWSGHYQLKDKLRVQLRPQRAGSEV LELGIHGESDDKLANVIFQPIQDRRGRTILLVRDQNTFGA ELRQKRLMTLIHLWLVHRFKAQAVHYVTPTDDNLYQTSKM KSHGIFTEVNQEVGEIIVAEVNHPRIAELLTPDRVALRKL ITK Description (1)  Isocitrate lyase 2 (E.C.4.1.3.1) Functional site 1) chain C residue 665 type sequence R description binding site for residue ACO A 801 source : AC1 2) chain C residue 674 type sequence R description binding site for residue ACO C 801 source : AC3 3) chain C residue 675 type sequence D description binding site for residue ACO C 801 source : AC3 4) chain C residue 676 type sequence Q description binding site for residue ACO C 801 source : AC3 5) chain C residue 677 type sequence N description binding site for residue ACO C 801 source : AC3 6) chain C residue 678 type sequence T description binding site for residue ACO C 801 source : AC3 7) chain C residue 684 type sequence R description binding site for residue ACO C 801 source : AC3 8) chain C residue 685 type sequence Q description binding site for residue ACO C 801 source : AC3 9) chain C residue 686 type sequence K description binding site for residue ACO C 801 source : AC3 10) chain C residue 687 type sequence R description binding site for residue ACO C 801 source : AC3 11) chain C residue 689 type sequence M description binding site for residue ACO C 801 source : AC3 12) chain C residue 690 type sequence T description binding site for residue ACO C 801 source : AC3 13) chain C residue 708 type sequence V description binding site for residue ACO C 801 source : AC3 14) chain C residue 711 type sequence T description binding site for residue ACO C 801 source : AC3 15) chain C residue 713 type sequence D description binding site for residue ACO C 801 source : AC3 16) chain C residue 714 type sequence N description binding site for residue ACO C 801 source : AC3 17) chain C residue 716 type sequence Y description binding site for residue ACO C 801 source : AC3 18) chain C residue 717 type sequence Q description binding site for residue ACO C 801 source : AC3 19) chain C residue 720 type sequence K description binding site for residue ACO C 801 source : AC3 20) chain C residue 724 type sequence H description binding site for residue ACO C 801 source : AC3 21) chain C residue 106 type BINDING sequence G description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2 22) chain C residue 177 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2 23) chain C residue 252 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2 24) chain C residue 487 type BINDING sequence N description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2 25) chain C residue 522 type BINDING sequence T description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2

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