eF-site ID 6edz-B PDB Code 6edz Chain B click to enlarge Title Crystal structure of Mycobacterium tuberculosis ICL2 in complex with acetyl-CoA, form I Classification LYASE Compound Isocitrate lyase 2 Source (ACEA2_MYCTO) Sequence B:  HTPFEQDFEKDVAATQRYFDSSRFAGIIRLYTARQVVEQR GTIPVDHIVAREAAGAFYERLRELFAARKSITTFGPYSPG QAVSMKRMGIEAIYLGGWATSAKGSSTEDPGPDLASYPLS QVPDDAAVLVRALLTADRNQHYLRLQMSERQRAATPAYDF RPFIIADADTGHGGDPHVRNLIRRFVEVGVPGYHIEDQRP GTKKQGGKVLVPSDEQIKRLNAARFQLDIMRVPGIIVART DAEAANLIDSRADERDQPFLLGATKLDVPSYKSCFLAMVR RFYELGVKELNGHLLYALGDSEYAAAGGWLERQGIFGLVS DAVNAWREDGQQDGIFDQVESRFVAAWEDDAGLMTYGEAV ADVLEFGAPEEWRAFAARASLHAARAKAKELGADPPWDCE LAKTPEGYYQIRGGIPYAIAKSLAAAPFADILWMETKTAD LADARQFAEAIHAEFPDQMLAYNLSPSFNWDTTGMTDEEM RRFPEELGKMGFVFNFITYGGHQIDGVAAEEFATALRQDG MLALARLQRKMRLVESPYRTPQTLVGGPRSDAALAASSGR TATTKAMQTEVPRKLLEEWLAMWSGHYQLKDKLRVQLRPQ RAGSEVLELGIHGESDDKLANVIFQPIQDRRGRTILLVRD QNTFGAELRQKRLMTLIHLWLVHRFKAQAVHYVTPTDDNL YQTSKMKSHGIFTEVNQEVGEIIVAEVNHPRIAELLTPDR VALRKLITKE Description (1)  Isocitrate lyase 2 (E.C.4.1.3.1) Functional site 1) chain B residue 673 type sequence V description binding site for residue ACO B 801 source : AC2 2) chain B residue 676 type sequence Q description binding site for residue ACO B 801 source : AC2 3) chain B residue 677 type sequence N description binding site for residue ACO B 801 source : AC2 4) chain B residue 678 type sequence T description binding site for residue ACO B 801 source : AC2 5) chain B residue 684 type sequence R description binding site for residue ACO B 801 source : AC2 6) chain B residue 685 type sequence Q description binding site for residue ACO B 801 source : AC2 7) chain B residue 686 type sequence K description binding site for residue ACO B 801 source : AC2 8) chain B residue 687 type sequence R description binding site for residue ACO B 801 source : AC2 9) chain B residue 689 type sequence M description binding site for residue ACO B 801 source : AC2 10) chain B residue 690 type sequence T description binding site for residue ACO B 801 source : AC2 11) chain B residue 708 type sequence V description binding site for residue ACO B 801 source : AC2 12) chain B residue 711 type sequence T description binding site for residue ACO B 801 source : AC2 13) chain B residue 713 type sequence D description binding site for residue ACO B 801 source : AC2 14) chain B residue 714 type sequence N description binding site for residue ACO B 801 source : AC2 15) chain B residue 716 type sequence Y description binding site for residue ACO B 801 source : AC2 16) chain B residue 717 type sequence Q description binding site for residue ACO B 801 source : AC2 17) chain B residue 720 type sequence K description binding site for residue ACO B 801 source : AC2 18) chain B residue 724 type sequence H description binding site for residue ACO B 801 source : AC2 19) chain B residue 764 type sequence K description binding site for residue ACO B 801 source : AC2 20) chain B residue 665 type sequence R description binding site for residue ACO D 801 source : AC4 21) chain B residue 252 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2 22) chain B residue 487 type BINDING sequence N description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2 23) chain B residue 522 type BINDING sequence T description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2 24) chain B residue 106 type BINDING sequence G description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2 25) chain B residue 177 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2

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