eF-site ID 6edz-A
PDB Code 6edz
Chain A

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Title Crystal structure of Mycobacterium tuberculosis ICL2 in complex with acetyl-CoA, form I
Classification LYASE
Compound Isocitrate lyase 2
Source (ACEA2_MYCTO)
Sequence A:  TPFEQDFEKDVAATQRYFDSSRFAGIIRLYTARQVVEQRG
TIPVDHIVAREAAGAFYERLRELFAARKSITTFGPYSPGQ
AVSMKRMGIEAIYLGGWATSAKGSSTEDPGPDLASYPLSQ
VPDDAAVLVRALLTADRNQHYLRLQMSERQRAATPAYDFR
PFIIADADTGHGGDPHVRNLIRRFVEVGVPGYHIEDQRPG
TKKXGHQGGKVLVPSDEQIKRLNAARFQLDIMRVPGIIVA
RTDAEAANLIDSRADERDQPFLLGATKLDVPSYKSCFLAM
VRRFYELGVKELNGHLLYALGDSEYAAAGGWLERQGIFGL
VSDAVNAWREDGQQSIDGIFDQVESRFVAAWEDDAGLMTY
GEAVADVLEAPEEWRAFAARASLHAARAKAKELGADPPWD
CELAKTPEGYYQIRGGIPYAIAKSLAAAPFADILWMETKT
ADLADARQFAEAIHAEFPDQMLAYNLSPSFNWDTTGMTDE
EMRRFPEELGKMGFVFNFITYGGHQIDGVAAEEFATALRQ
DGMLALARLQRKMRLVESPYRTPQTLVGGPRSDAALAASS
GRTATTKALVQTEVPRKLLEEWLAMWSGHYQLKDKLRVQL
RPQRAGSEVLELGIHGESDDKLANVIFQPIQDRRGRTILL
VRDQNTFGAELRQKRLMTLIHLWLVHRFKAQAVHYVTPTD
DNLYQTSKMKSHGIFTEVNQEVGEIIVAEVNHPRIAELLT
PDRVALRKLITKE
Description (1)  Isocitrate lyase 2 (E.C.4.1.3.1)


Functional site

1) chain A
residue 676
type
sequence Q
description binding site for residue ACO A 801
source : AC1

2) chain A
residue 677
type
sequence N
description binding site for residue ACO A 801
source : AC1

3) chain A
residue 678
type
sequence T
description binding site for residue ACO A 801
source : AC1

4) chain A
residue 684
type
sequence R
description binding site for residue ACO A 801
source : AC1

5) chain A
residue 685
type
sequence Q
description binding site for residue ACO A 801
source : AC1

6) chain A
residue 686
type
sequence K
description binding site for residue ACO A 801
source : AC1

7) chain A
residue 687
type
sequence R
description binding site for residue ACO A 801
source : AC1

8) chain A
residue 689
type
sequence M
description binding site for residue ACO A 801
source : AC1

9) chain A
residue 690
type
sequence T
description binding site for residue ACO A 801
source : AC1

10) chain A
residue 708
type
sequence V
description binding site for residue ACO A 801
source : AC1

11) chain A
residue 709
type
sequence T
description binding site for residue ACO A 801
source : AC1

12) chain A
residue 710
type
sequence P
description binding site for residue ACO A 801
source : AC1

13) chain A
residue 711
type
sequence T
description binding site for residue ACO A 801
source : AC1

14) chain A
residue 713
type
sequence D
description binding site for residue ACO A 801
source : AC1

15) chain A
residue 714
type
sequence N
description binding site for residue ACO A 801
source : AC1

16) chain A
residue 716
type
sequence Y
description binding site for residue ACO A 801
source : AC1

17) chain A
residue 717
type
sequence Q
description binding site for residue ACO A 801
source : AC1

18) chain A
residue 720
type
sequence K
description binding site for residue ACO A 801
source : AC1

19) chain A
residue 724
type
sequence H
description binding site for residue ACO A 801
source : AC1

20) chain A
residue 764
type
sequence K
description binding site for residue ACO A 801
source : AC1

21) chain A
residue 213-218
type prosite
sequence KKXGHQ
description ISOCITRATE_LYASE Isocitrate lyase signature. KKCGHQ
source prosite : PS00161

22) chain A
residue 215
type ACT_SITE
sequence X
description Proton acceptor => ECO:0000250|UniProtKB:P9WKK7
source Swiss-Prot : SWS_FT_FI1

23) chain A
residue 106
type BINDING
sequence G
description BINDING => ECO:0000250|UniProtKB:P9WKK7
source Swiss-Prot : SWS_FT_FI2

24) chain A
residue 177
type BINDING
sequence D
description BINDING => ECO:0000250|UniProtKB:P9WKK7
source Swiss-Prot : SWS_FT_FI2

25) chain A
residue 216
type BINDING
sequence G
description BINDING => ECO:0000250|UniProtKB:P9WKK7
source Swiss-Prot : SWS_FT_FI2

26) chain A
residue 252
type BINDING
sequence R
description BINDING => ECO:0000250|UniProtKB:P9WKK7
source Swiss-Prot : SWS_FT_FI2

27) chain A
residue 487
type BINDING
sequence N
description BINDING => ECO:0000250|UniProtKB:P9WKK7
source Swiss-Prot : SWS_FT_FI2

28) chain A
residue 522
type BINDING
sequence T
description BINDING => ECO:0000250|UniProtKB:P9WKK7
source Swiss-Prot : SWS_FT_FI2


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