eF-site ID 6edz-A PDB Code 6edz Chain A click to enlarge Title Crystal structure of Mycobacterium tuberculosis ICL2 in complex with acetyl-CoA, form I Classification LYASE Compound Isocitrate lyase 2 Source (ACEA2_MYCTO) Sequence A:  TPFEQDFEKDVAATQRYFDSSRFAGIIRLYTARQVVEQRG TIPVDHIVAREAAGAFYERLRELFAARKSITTFGPYSPGQ AVSMKRMGIEAIYLGGWATSAKGSSTEDPGPDLASYPLSQ VPDDAAVLVRALLTADRNQHYLRLQMSERQRAATPAYDFR PFIIADADTGHGGDPHVRNLIRRFVEVGVPGYHIEDQRPG TKKXGHQGGKVLVPSDEQIKRLNAARFQLDIMRVPGIIVA RTDAEAANLIDSRADERDQPFLLGATKLDVPSYKSCFLAM VRRFYELGVKELNGHLLYALGDSEYAAAGGWLERQGIFGL VSDAVNAWREDGQQSIDGIFDQVESRFVAAWEDDAGLMTY GEAVADVLEAPEEWRAFAARASLHAARAKAKELGADPPWD CELAKTPEGYYQIRGGIPYAIAKSLAAAPFADILWMETKT ADLADARQFAEAIHAEFPDQMLAYNLSPSFNWDTTGMTDE EMRRFPEELGKMGFVFNFITYGGHQIDGVAAEEFATALRQ DGMLALARLQRKMRLVESPYRTPQTLVGGPRSDAALAASS GRTATTKALVQTEVPRKLLEEWLAMWSGHYQLKDKLRVQL RPQRAGSEVLELGIHGESDDKLANVIFQPIQDRRGRTILL VRDQNTFGAELRQKRLMTLIHLWLVHRFKAQAVHYVTPTD DNLYQTSKMKSHGIFTEVNQEVGEIIVAEVNHPRIAELLT PDRVALRKLITKE Description (1)  Isocitrate lyase 2 (E.C.4.1.3.1) Functional site 1) chain A residue 676 type sequence Q description binding site for residue ACO A 801 source : AC1 2) chain A residue 677 type sequence N description binding site for residue ACO A 801 source : AC1 3) chain A residue 678 type sequence T description binding site for residue ACO A 801 source : AC1 4) chain A residue 684 type sequence R description binding site for residue ACO A 801 source : AC1 5) chain A residue 685 type sequence Q description binding site for residue ACO A 801 source : AC1 6) chain A residue 686 type sequence K description binding site for residue ACO A 801 source : AC1 7) chain A residue 687 type sequence R description binding site for residue ACO A 801 source : AC1 8) chain A residue 689 type sequence M description binding site for residue ACO A 801 source : AC1 9) chain A residue 690 type sequence T description binding site for residue ACO A 801 source : AC1 10) chain A residue 708 type sequence V description binding site for residue ACO A 801 source : AC1 11) chain A residue 709 type sequence T description binding site for residue ACO A 801 source : AC1 12) chain A residue 710 type sequence P description binding site for residue ACO A 801 source : AC1 13) chain A residue 711 type sequence T description binding site for residue ACO A 801 source : AC1 14) chain A residue 713 type sequence D description binding site for residue ACO A 801 source : AC1 15) chain A residue 714 type sequence N description binding site for residue ACO A 801 source : AC1 16) chain A residue 716 type sequence Y description binding site for residue ACO A 801 source : AC1 17) chain A residue 717 type sequence Q description binding site for residue ACO A 801 source : AC1 18) chain A residue 720 type sequence K description binding site for residue ACO A 801 source : AC1 19) chain A residue 724 type sequence H description binding site for residue ACO A 801 source : AC1 20) chain A residue 764 type sequence K description binding site for residue ACO A 801 source : AC1 21) chain A residue 213-218 type prosite sequence KKXGHQ description ISOCITRATE_LYASE Isocitrate lyase signature. KKCGHQ source prosite : PS00161 22) chain A residue 215 type ACT_SITE sequence X description Proton acceptor => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI1 23) chain A residue 106 type BINDING sequence G description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2 24) chain A residue 177 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2 25) chain A residue 216 type BINDING sequence G description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2 26) chain A residue 252 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2 27) chain A residue 487 type BINDING sequence N description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2 28) chain A residue 522 type BINDING sequence T description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2

Display surface Download Links