eF-site ID 6edw-D PDB Code 6edw Chain D click to enlarge Title Crystal structure of Mycobacterium tuberculosis ICL2 in the apo form Classification LYASE Compound Isocitrate lyase 2 Source (ACEA2_MYCTO) Sequence D:  HTPFEQDFEKDVAATQRYFDSSRFAGIIRLYTARQVVEQR GTIPVDHIVAREAAGAFYERLRELFAARKSITTFGPYSPG QAVSMKRMGIEAIYLGGWATSAKGSSTEDPGPDLASYPLS QVPDDAAVLVRALLTADRNQHYLRLQMSERQRAATPAYDF RPFIIADADTGHGGDPHVRNLIRRFVEVGVPGYHIEDQRP GTKKXGHQGGKVLVPSDEQIKRLNAARFQLDIMRVPGIIV ARTDAEAANLIDSRADERDQPFLLGATKLDVPSYKSCFLA MVRRFYELGVKELNGHLLYALGDSEYAAAGGWLERQGIFG LVSDAVNAWREDGQQSIDGIFDQVESRFVAAWEDDAGLMT YGEAVADVLEFGQSEGEPIGMAPEEWRAFAARASLHAARA KAKELGADPPWDCELAKTPEGYYQIRGGIPYAIAKSLAAA PFADILWMETKTADLADARQFAEAIHAEFPDQMLAYNLSP SFNWDTTGMTDEEMRRFPEELGKMGFVFNFITYGGHQIDG VAAEEFATALRQDGMLALARLQRKMRLVESPYRTPQTLVG GPRSDAALAASSGRTATTKAMGEVPRKLLEEWLAMWSGHY QLKDKLRVQLRPQRAGSEVLELGIHGESDDKLANVIFQPI QDRRGRTILLVRDQNTFGALRQKRLMTLIHLWLVHRFKAQ AVHYVTPTDDNLYQTSKMKSHGIFTEVNQEVGEIIVAEVN HPRIAELLTPDRVALRKLITK Description (1)  Isocitrate lyase 2 (E.C.4.1.3.1) Functional site 1) chain D residue 18 type sequence F description binding site for residue GOL C 802 source : AC7 2) chain D residue 52 type sequence T description binding site for residue GOL C 802 source : AC7 3) chain D residue 151 type sequence H description binding site for residue GOL D 801 source : AD1 4) chain D residue 450 type sequence A description binding site for residue MG D 802 source : AD2 5) chain D residue 453 type sequence A description binding site for residue MG D 802 source : AD2 6) chain D residue 482 type sequence Q description binding site for residue MG D 802 source : AD2 7) chain D residue 123 type sequence D description binding site for residue MG D 803 source : AD3 8) chain D residue 177 type sequence D description binding site for residue MG D 803 source : AD3 9) chain D residue 179 type sequence D description binding site for residue MG D 803 source : AD3 10) chain D residue 213 type sequence K description binding site for residue MG D 803 source : AD3 11) chain D residue 106 type BINDING sequence G description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2 12) chain D residue 177 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2 13) chain D residue 216 type BINDING sequence G description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2 14) chain D residue 252 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2 15) chain D residue 487 type BINDING sequence N description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2 16) chain D residue 522 type BINDING sequence T description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2 17) chain D residue 215 type ACT_SITE sequence X description Proton acceptor => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI1

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