eF-site ID 6edw-C PDB Code 6edw Chain C click to enlarge Title Crystal structure of Mycobacterium tuberculosis ICL2 in the apo form Classification LYASE Compound Isocitrate lyase 2 Source (ACEA2_MYCTO) Sequence C:  TPFEQDFEKDVAATQRYFDSSRFAGIIRLYTARQVVEQRG TIPVDHIVAREAAGAFYERLRELFAARKSITTFGPYSPGQ AVSMKRMGIEAIYLGGWATSAKGSSTEDPGPDLASYPLSQ VPDDAAVLVRALLTADRNQHYLRLQMSERQRAATPAYDFR PFIIADADTGHGGDPHVRNLIRRFVEVGVPGYHIEDQRPG TKKXGHQGGKVLVPSDEQIKRLNAARFQLDIMRVPGIIVA RTDAEAANLIDSRADERDQPFLLGATKLDVPSYKSCFLAM VRRFYELGVKELNGHLLYALGDSEYAAAGGWLERQGIFGL VSDAVNAWREDGQQSIDGIFDQVESRFVAAWEDDAGLMTY GEAVADVLEFGQSEGEPGMAPEEWRAFAARASLHAARAKA KELGADPPWDCELAKTPEGYYQIRGGIPYAIAKSLAAAPF ADILWMETKTADLADARQFAEAIHAEFPDQMLAYNLSPSF NWDTTGMTDEEMRRFPEELGKMGFVFNFITYGGHQIDGVA AEEFATALRQDGMLALARLQRKMRLVESPYRTPQTLVGGP RSDAALAASSGRTATTKAMGVPRKLLEEWLAMWGHLRVQL RPQRAGSEVLELGIHLANVIFQPIQDRRGRTILLVRDQNT FGAELRQKRLMTLIHLWLVHRFKAQAVHYVTPTDDNLYQT SKMKSHGIFTEVNQEVGEIIVAEVNHPRIAELLTPDRVAL RKLI Description (1)  Isocitrate lyase 2 (E.C.4.1.3.1) Functional site 1) chain C residue 78 type sequence R description binding site for residue GOL C 801 source : AC6 2) chain C residue 472 type sequence A description binding site for residue GOL C 801 source : AC6 3) chain C residue 476 type sequence H description binding site for residue GOL C 801 source : AC6 4) chain C residue 513 type sequence K description binding site for residue GOL C 801 source : AC6 5) chain C residue 514 type sequence M description binding site for residue GOL C 801 source : AC6 6) chain C residue 151 type sequence H description binding site for residue GOL C 802 source : AC7 7) chain C residue 450 type sequence A description binding site for residue MG C 803 source : AC8 8) chain C residue 453 type sequence A description binding site for residue MG C 803 source : AC8 9) chain C residue 482 type sequence Q description binding site for residue MG C 803 source : AC8 10) chain C residue 177 type sequence D description binding site for residue MG C 804 source : AC9 11) chain C residue 179 type sequence D description binding site for residue MG C 804 source : AC9 12) chain C residue 213 type sequence K description binding site for residue MG C 804 source : AC9 13) chain C residue 17 type sequence D description binding site for residue GOL D 801 source : AD1 14) chain C residue 18 type sequence F description binding site for residue GOL D 801 source : AD1 15) chain C residue 52 type sequence T description binding site for residue GOL D 801 source : AD1 16) chain C residue 215 type ACT_SITE sequence X description Proton acceptor => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI1 17) chain C residue 106 type BINDING sequence G description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2 18) chain C residue 177 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2 19) chain C residue 216 type BINDING sequence G description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2 20) chain C residue 252 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2 21) chain C residue 487 type BINDING sequence N description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2 22) chain C residue 522 type BINDING sequence T description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2

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