eF-site ID 6edw-A PDB Code 6edw Chain A click to enlarge Title Crystal structure of Mycobacterium tuberculosis ICL2 in the apo form Classification LYASE Compound Isocitrate lyase 2 Source (ACEA2_MYCTO) Sequence A:  TPFEQDFEKDVAATQRYFDSSRFAGIIRLYTARQVVEQRG TIPVDHIVAREAAGAFYERLRELFAARKSITTFGPYSPGQ AVSMKRMGIEAIYLGGWATSAKGSSTEDPGPDLASYPLSQ VPDDAAVLVRALLTADRNQHYLRLQMSERQRAATPAYDFR PFIIADADTGHGGDPHVRNLIRRFVEVGVPGYHIEDQRPG TKKXGHQGGKVLVPSDEQIKRLNAARFQLDIMRVPGIIVA RTDAEAANLIDSRADERDQPFLLGATKLDVPSYKSCFLAM VRRFYELGVKELNGHLLYALGDSEYAAAGGWLERQGIFGL VSDAVNAWREDGQQSIDGIFDQVESRFVAAWEDDAGLMTY GEAVADVLEFGMAPEEWRAFAARASLHAARAKAKELGADP PWDCELAKTPEGYYQIRGGIPYAIAKSLAAAPFADILWME TKTADLADARQFAEAIHAEFPDQMLAYNLSPSFNWDTTGM TDEEMRRFPEELGKMGFVFNFITYGGHQIDGVAAEEFATA LRQDGMLALARLQRKMRLVESPYRTPQTLVGGPRSDAALA ASSGRTATTKAMSTQHQHLVQTEVPRKLLEEWLAMWSGHY QLKDKLRVQLRPQRAGSEVLELGIHGESDDKLANVIFQPI QDRRGRTILLVRDQNTFGAELRQKRLMTLIHLWLVHRFKA QAVHYVTPTDDNLYQTSKMKSHGIFTEVNQEVGEIIVAEV NHPRIAELLTPDRVALRKLITK Description (1)  Isocitrate lyase 2 (E.C.4.1.3.1) Functional site 1) chain A residue 17 type sequence D description binding site for residue GOL A 801 source : AC1 2) chain A residue 18 type sequence F description binding site for residue GOL A 801 source : AC1 3) chain A residue 52 type sequence T description binding site for residue GOL A 801 source : AC1 4) chain A residue 151 type sequence H description binding site for residue GOL A 802 source : AC2 5) chain A residue 450 type sequence A description binding site for residue MG A 803 source : AC3 6) chain A residue 453 type sequence A description binding site for residue MG A 803 source : AC3 7) chain A residue 482 type sequence Q description binding site for residue MG A 803 source : AC3 8) chain A residue 123 type sequence D description binding site for residue MG A 804 source : AC4 9) chain A residue 177 type sequence D description binding site for residue MG A 804 source : AC4 10) chain A residue 179 type sequence D description binding site for residue MG A 804 source : AC4 11) chain A residue 213 type sequence K description binding site for residue MG A 804 source : AC4 12) chain A residue 213-218 type prosite sequence KKXGHQ description ISOCITRATE_LYASE Isocitrate lyase signature. KKCGHQ source prosite : PS00161 13) chain A residue 215 type ACT_SITE sequence X description Proton acceptor => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI1 14) chain A residue 106 type BINDING sequence G description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2 15) chain A residue 177 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2 16) chain A residue 216 type BINDING sequence G description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2 17) chain A residue 252 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2 18) chain A residue 487 type BINDING sequence N description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2 19) chain A residue 522 type BINDING sequence T description BINDING => ECO:0000250|UniProtKB:P9WKK7 source Swiss-Prot : SWS_FT_FI2

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