eF-site ID 6e67-B PDB Code 6e67 Chain B click to enlarge Title Structure of beta2 adrenergic receptor fused to a Gs peptide Classification MEMBRANE PROTEIN Compound Beta-2 adrenergic receptor,Endolysin,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Beta-2 adrenergic receptor chimera Source (ADRB2_HUMAN) Sequence B:  FLLAPNRSHAPDHDVTQQRDEVWVVGMGIVMSLIVLAIVF GNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPF GAAHILTKTWTFGNFWCEFWTSIDVLCVTASIETLCVIAV DRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPI QMHWYRATHQEAINCYAEETCCDFFTNQAYAIASSIVSFY VPLVIMVFVYSRVFQECKRQLQKNIFEMLRIDEGLRLKIY KDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNTNGVI TKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAA LINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRW YNQTPNRAKRVITTFRTGTWDAYDIIQRMHLRQYELCGTG EHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEV YILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLR Description Functional site 1) chain B residue 109 type sequence W description binding site for residue P0G B 3101 source : AC2 2) chain B residue 113 type sequence D description binding site for residue P0G B 3101 source : AC2 3) chain B residue 117 type sequence V description binding site for residue P0G B 3101 source : AC2 4) chain B residue 193 type sequence F description binding site for residue P0G B 3101 source : AC2 5) chain B residue 200 type sequence A description binding site for residue P0G B 3101 source : AC2 6) chain B residue 203 type sequence S description binding site for residue P0G B 3101 source : AC2 7) chain B residue 207 type sequence S description binding site for residue P0G B 3101 source : AC2 8) chain B residue 293 type sequence N description binding site for residue P0G B 3101 source : AC2 9) chain B residue 308 type sequence Y description binding site for residue P0G B 3101 source : AC2 10) chain B residue 309 type sequence I description binding site for residue P0G B 3101 source : AC2 11) chain B residue 312 type sequence N description binding site for residue P0G B 3101 source : AC2 12) chain B residue 96-106 type TOPO_DOM sequence TKTWTFGNFWC description Extracellular source Swiss-Prot : SWS_FT_FI1 13) chain B residue 175-196 type TOPO_DOM sequence RATHQEAINCYAEETCCDFFTN description Extracellular source Swiss-Prot : SWS_FT_FI1 14) chain B residue 299-305 type TOPO_DOM sequence QDNLIRK description Extracellular source Swiss-Prot : SWS_FT_FI1 15) chain B residue 35-58 type TRANSMEM sequence GMGIVMSLIVLAIVFGNVLVITAI description Helical; Name=1 source Swiss-Prot : SWS_FT_FI2 16) chain B residue 59-71 type TOPO_DOM sequence AKFERLQTVTNYF description Cytoplasmic source Swiss-Prot : SWS_FT_FI3 17) chain B residue 130-150 type TOPO_DOM sequence DRYFAITSPFKYQSLLTKNKA description Cytoplasmic source Swiss-Prot : SWS_FT_FI3 18) chain B residue 72-95 type TRANSMEM sequence ITSLACADLVMGLAVVPFGAAHIL description Helical; Name=2 source Swiss-Prot : SWS_FT_FI4 19) chain B residue 107-129 type TRANSMEM sequence EFWTSIDVLCVTASIETLCVIAV description Helical; Name=3 source Swiss-Prot : SWS_FT_FI5 20) chain B residue 151-174 type TRANSMEM sequence RVIILMVWIVSGLTSFLPIQMHWY description Helical; Name=4 source Swiss-Prot : SWS_FT_FI6 21) chain B residue 197-220 type TRANSMEM sequence QAYAIASSIVSFYVPLVIMVFVYS description Helical; Name=5 source Swiss-Prot : SWS_FT_FI7 22) chain B residue 275-298 type TRANSMEM sequence LGIIMGTFTLCWLPFFIVNIVHVI description Helical; Name=6 source Swiss-Prot : SWS_FT_FI8 23) chain B residue 306-329 type TRANSMEM sequence EVYILLNWIGYVNSGFNPLIYCRS description Helical; Name=7 source Swiss-Prot : SWS_FT_FI9 24) chain B residue 316 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:18547522, ECO:0007744|PDB:3D4S source Swiss-Prot : SWS_FT_FI10 25) chain B residue 113 type BINDING sequence D description BINDING => ECO:0000269|PubMed:18547522, ECO:0007744|PDB:3D4S source Swiss-Prot : SWS_FT_FI10 26) chain B residue 118 type BINDING sequence T description BINDING => ECO:0000269|PubMed:18547522, ECO:0007744|PDB:3D4S source Swiss-Prot : SWS_FT_FI10 27) chain B residue 293 type BINDING sequence N description BINDING => ECO:0000269|PubMed:18547522, ECO:0007744|PDB:3D4S source Swiss-Prot : SWS_FT_FI10 28) chain B residue 312 type BINDING sequence N description BINDING => ECO:0000269|PubMed:18547522, ECO:0007744|PDB:3D4S source Swiss-Prot : SWS_FT_FI10 29) chain B residue 203 type BINDING sequence S description BINDING => ECO:0000269|PubMed:17952055, ECO:0000269|PubMed:17962520, ECO:0007744|PDB:2RH1 source Swiss-Prot : SWS_FT_FI11 30) chain B residue 141 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000269|PubMed:8521811 source Swiss-Prot : SWS_FT_FI12 31) chain B residue 341 type LIPID sequence C description S-palmitoyl cysteine => ECO:0000269|PubMed:17962520, ECO:0000269|PubMed:18547522, ECO:0000269|PubMed:2540197, ECO:0000269|PubMed:27481942 source Swiss-Prot : SWS_FT_FI15 32) chain B residue 15 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000305 source Swiss-Prot : SWS_FT_FI16

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