eF-site ID 6e5g-B PDB Code 6e5g Chain B click to enlarge Title Crystal structure of human TEAD2-Yap binding domain covalently bound to an allosteric regulator Classification TRANSCRIPTION/INHIBITOR Compound Transcriptional enhancer factor TEF-4 Source (TEAD2_HUMAN) Sequence B:  WQARGLGTARLQLVEFSAFVEPPDAVDSYQRHLFVHISQP PLESVDVRQIYDKFPEKKGGLRELYDRGPPHAFFLVKFWA DLNWSGGFYGVSSQYESLEHMTLTCSSKVCSFGKQVVEKV ETERAQLEDGRFVYRLLRSPMCEYLVNFLHKLRQLPERYM MNSVLENFTILQVVTNRDTQELLLCTAYVFEVSTSERGAQ HHIYRLVR Description Functional site 1) chain B residue 233 type sequence F description binding site for residue HUY B 501 source : AC1 2) chain B residue 235 type sequence A description binding site for residue HUY B 501 source : AC1 3) chain B residue 252 type sequence V description binding site for residue HUY B 501 source : AC1 4) chain B residue 329 type sequence V description binding site for residue HUY B 501 source : AC1 5) chain B residue 345 type sequence S description binding site for residue HUY B 501 source : AC1 6) chain B residue 357 type sequence K description binding site for residue HUY B 501 source : AC1 7) chain B residue 377 type sequence S description binding site for residue HUY B 501 source : AC1 8) chain B residue 378 type sequence P description binding site for residue HUY B 501 source : AC1 9) chain B residue 380 type sequence C description binding site for residue HUY B 501 source : AC1 10) chain B residue 383 type sequence L description binding site for residue HUY B 501 source : AC1 11) chain B residue 408 type sequence I description binding site for residue HUY B 501 source : AC1 12) chain B residue 410 type sequence Q description binding site for residue HUY B 501 source : AC1

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