eF-site ID 6e4u-A PDB Code 6e4u Chain A click to enlarge Title Structure of AMPK bound to activator Classification TRANSFERASE Compound 5'-AMP-activated protein kinase catalytic subunit alpha-1 Source (AAKG1_RAT) Sequence A:  GRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILN RQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSD IFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGE FLRXSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALL CGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHM LQVDPMKRATIKDIREHEWFKQDLPKYLFPEKWHLGIRSQ SRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTST FSKMSLQLYQVDSRTYLLDFRSIDDPGSHTIEFFEMCANL IKILAQ Description (1)  5'-AMP-activated protein kinase catalytic subunit alpha-1,5'-AMP-activated protein kinase catalytic subunit alpha-1 (E.C.2.7.11.1,2.7.11.1,2.7.11.27,2.7.11.31,2.7.11.26), 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1 Functional site 1) chain A residue 22 type sequence L description binding site for residue STU A 601 source : AC1 2) chain A residue 23 type sequence G description binding site for residue STU A 601 source : AC1 3) chain A residue 24 type sequence V description binding site for residue STU A 601 source : AC1 4) chain A residue 25 type sequence G description binding site for residue STU A 601 source : AC1 5) chain A residue 30 type sequence V description binding site for residue STU A 601 source : AC1 6) chain A residue 43 type sequence A description binding site for residue STU A 601 source : AC1 7) chain A residue 94 type sequence E description binding site for residue STU A 601 source : AC1 8) chain A residue 95 type sequence Y description binding site for residue STU A 601 source : AC1 9) chain A residue 96 type sequence V description binding site for residue STU A 601 source : AC1 10) chain A residue 99 type sequence G description binding site for residue STU A 601 source : AC1 11) chain A residue 100 type sequence E description binding site for residue STU A 601 source : AC1 12) chain A residue 143 type sequence E description binding site for residue STU A 601 source : AC1 13) chain A residue 144 type sequence N description binding site for residue STU A 601 source : AC1 14) chain A residue 146 type sequence L description binding site for residue STU A 601 source : AC1 15) chain A residue 156 type sequence A description binding site for residue STU A 601 source : AC1 16) chain A residue 157 type sequence D description binding site for residue STU A 601 source : AC1 17) chain A residue 18 type sequence L description binding site for residue HU7 A 602 source : AC2 18) chain A residue 19 type sequence G description binding site for residue HU7 A 602 source : AC2 19) chain A residue 29 type sequence K description binding site for residue HU7 A 602 source : AC2 20) chain A residue 31 type sequence K description binding site for residue HU7 A 602 source : AC2 21) chain A residue 46 type sequence I description binding site for residue HU7 A 602 source : AC2 22) chain A residue 88 type sequence D description binding site for residue HU7 A 602 source : AC2 23) chain A residue 97 type sequence S description binding site for residue CL A 603 source : AC3 24) chain A residue 149 type sequence A description binding site for residue CL A 603 source : AC3 25) chain A residue 210 type sequence G description binding site for residue CL A 604 source : AC4 26) chain A residue 24 type sequence V description binding site for residue CL A 605 source : AC5 27) chain A residue 34 type sequence K description binding site for residue CL A 606 source : AC6 28) chain A residue 41 type sequence K description binding site for residue CL A 606 source : AC6 29) chain A residue 456 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:Q13131 source Swiss-Prot : SWS_FT_FI6 30) chain A residue 22-45 type prosite sequence LGVGTFGKVKVGKHELTGHKVAVK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGVGTFGKVKvGkheltghk..........VAVK source prosite : PS00107 31) chain A residue 135-147 type prosite sequence VVHRDLKPENVLL description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VvHrDLKpeNVLL source prosite : PS00108

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