eF-site ID 6e3t-B PDB Code 6e3t Chain B click to enlarge Title Crystal Structure of the Heterodimeric HIF-2 Complex with Antagonist T1001 Classification transcription/transcription inhibitor Compound Aryl hydrocarbon receptor nuclear translocator Source (EPAS1_MOUSE) Sequence B:  ETEVFYELAHELPHSVSSHLDKASIMRLAISFLRTHKLLS SVCDNLYLKALEGFIAVVTQDGDMIFLSENISKFMGLTQV ELTGHSIFDFTHPCDHEEIRENLTLSTERDFFMRMKCTVT NRTVNLKSATWKVLHCTGQVRVLSCLIIMCEPIQHPSHMD IPLDSKTFLSRHSMDMKFTYCDDRILELIGYHPEELLGRS AYEFYHALDSENMTKSHQNLCTKGQVVSGQYRMLAKHGGY VWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSM D Description Functional site 1) chain B residue 244 type sequence F description binding site for residue HO7 B 401 source : AC1 2) chain B residue 248 type sequence H description binding site for residue HO7 B 401 source : AC1 3) chain B residue 277 type sequence A description binding site for residue HO7 B 401 source : AC1 4) chain B residue 281 type sequence Y description binding site for residue HO7 B 401 source : AC1 5) chain B residue 302 type sequence V description binding site for residue HO7 B 401 source : AC1 6) chain B residue 307 type sequence Y description binding site for residue HO7 B 401 source : AC1 7) chain B residue 309 type sequence M description binding site for residue HO7 B 401 source : AC1 8) chain B residue 319 type sequence L description binding site for residue HO7 B 401 source : AC1 9) chain B residue 321 type sequence T description binding site for residue HO7 B 401 source : AC1 10) chain B residue 339 type sequence C description binding site for residue HO7 B 401 source : AC1 11) chain B residue 341 type sequence N description binding site for residue HO7 B 401 source : AC1

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