eF-site ID 6e3s-AB
PDB Code 6e3s
Chain A, B

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Title Crystal Structure of the Heterodimeric HIF-2 Complex with Antagonist PT2385
Classification transcription/transcription inhibitor
Compound Aryl hydrocarbon receptor nuclear translocator
Source (EPAS1_MOUSE)
Sequence A:  ERRRRNKMTAYITELSDMVPTCPDKLTILRMAVSHMKSLL
TDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQ
PQSEWFGSTLYDQVHPDDVDKLREQLSTSRRSFICRMRCG
TPHFVVVHCTGYIKAWFCLVAIGRLQTEFISRHNIEGIFT
FVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQ
VVKLKGQVLSVMFRFRSKTREWLWMRTSSFTFQNPYSDEI
EYIICTNTNV
B:  SKETEVFYELAHELPLPHSVSSHLDKASIMRLAISFLRTH
KLLSSVCDNLYLKALEGFIAVVTQDGDMIFLSENISKFMG
LTQVELTGHSIFDFTHPCDHEEIRENLTLSTERDFFMRMK
CTVTNRGRTVNLKSATWKVLHCTGQVRVLSCLIIMCEPIQ
HPSHMDIPLDSKTFLSRHSMDMKFTYCDDRILELIGYHPE
ELLGRSAYEFYHALDSENMTKSHQNLCTKGQVVSGQYRML
AKHGGYVALETQGTVIYNPRNLQPQCIMCVNYVLSEIEKN
DVVFSMDQTE
Description


Functional site

1) chain B
residue 244
type
sequence F
description binding site for residue 79A B 401
source : AC1

2) chain B
residue 246
type
sequence S
description binding site for residue 79A B 401
source : AC1

3) chain B
residue 248
type
sequence H
description binding site for residue 79A B 401
source : AC1

4) chain B
residue 252
type
sequence M
description binding site for residue 79A B 401
source : AC1

5) chain B
residue 254
type
sequence F
description binding site for residue 79A B 401
source : AC1

6) chain B
residue 277
type
sequence A
description binding site for residue 79A B 401
source : AC1

7) chain B
residue 280
type
sequence F
description binding site for residue 79A B 401
source : AC1

8) chain B
residue 281
type
sequence Y
description binding site for residue 79A B 401
source : AC1

9) chain B
residue 293
type
sequence H
description binding site for residue 79A B 401
source : AC1

10) chain B
residue 296
type
sequence L
description binding site for residue 79A B 401
source : AC1

11) chain B
residue 302
type
sequence V
description binding site for residue 79A B 401
source : AC1

12) chain B
residue 304
type
sequence S
description binding site for residue 79A B 401
source : AC1

13) chain B
residue 309
type
sequence M
description binding site for residue 79A B 401
source : AC1

14) chain B
residue 321
type
sequence T
description binding site for residue 79A B 401
source : AC1

15) chain B
residue 323
type
sequence G
description binding site for residue 79A B 401
source : AC1

16) chain B
residue 337
type
sequence I
description binding site for residue 79A B 401
source : AC1

17) chain B
residue 339
type
sequence C
description binding site for residue 79A B 401
source : AC1

18) chain B
residue 341
type
sequence N
description binding site for residue 79A B 401
source : AC1


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