eF-site ID 6e3e-AB PDB Code 6e3e Chain A, B click to enlarge Title Structure of RORgt in complex with a novel inverse agonist. Classification nuclear protein/agonist Compound Nuclear receptor ROR-gamma Source (RORG_HUMAN) Sequence A:  ASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREE VTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMEL CQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGG MELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALV LINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILA KLPPKGKLRSLCSQHVE B:  ASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREE VTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMEL CQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGG MELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALV LINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILA KLPPKGKLRSLCSQHVE Description Functional site 1) chain A residue 451 type sequence H description binding site for residue SO4 A 501 source : AC1 2) chain A residue 463 type sequence L description binding site for residue SO4 A 501 source : AC1 3) chain B residue 451 type sequence H description binding site for residue SO4 A 501 source : AC1 4) chain A residue 290 type sequence E description binding site for residue MPD A 502 source : AC2 5) chain A residue 304 type sequence E description binding site for residue MPD A 502 source : AC2 6) chain A residue 308 type sequence Y description binding site for residue MPD A 502 source : AC2 7) chain A residue 311 type sequence K description binding site for residue MPD A 502 source : AC2 8) chain A residue 286 type sequence Q description binding site for residue HQ7 A 503 source : AC3 9) chain A residue 320 type sequence C description binding site for residue HQ7 A 503 source : AC3 10) chain A residue 323 type sequence H description binding site for residue HQ7 A 503 source : AC3 11) chain A residue 324 type sequence L description binding site for residue HQ7 A 503 source : AC3 12) chain A residue 361 type sequence V description binding site for residue HQ7 A 503 source : AC3 13) chain A residue 364 type sequence R description binding site for residue HQ7 A 503 source : AC3 14) chain A residue 365 type sequence M description binding site for residue HQ7 A 503 source : AC3 15) chain A residue 368 type sequence A description binding site for residue HQ7 A 503 source : AC3 16) chain A residue 377 type sequence F description binding site for residue HQ7 A 503 source : AC3 17) chain A residue 378 type sequence F description binding site for residue HQ7 A 503 source : AC3 18) chain A residue 379 type sequence E description binding site for residue HQ7 A 503 source : AC3 19) chain B residue 336 type sequence K description binding site for residue SO4 B 501 source : AC4 20) chain B residue 290 type sequence E description binding site for residue MPD B 502 source : AC5 21) chain B residue 304 type sequence E description binding site for residue MPD B 502 source : AC5 22) chain B residue 311 type sequence K description binding site for residue MPD B 502 source : AC5 23) chain B residue 319 type sequence R description binding site for residue MPD B 502 source : AC5 24) chain B residue 320 type sequence C description binding site for residue HQ7 B 503 source : AC6 25) chain B residue 323 type sequence H description binding site for residue HQ7 B 503 source : AC6 26) chain B residue 324 type sequence L description binding site for residue HQ7 B 503 source : AC6 27) chain B residue 361 type sequence V description binding site for residue HQ7 B 503 source : AC6 28) chain B residue 365 type sequence M description binding site for residue HQ7 B 503 source : AC6 29) chain B residue 368 type sequence A description binding site for residue HQ7 B 503 source : AC6 30) chain B residue 377 type sequence F description binding site for residue HQ7 B 503 source : AC6 31) chain B residue 378 type sequence F description binding site for residue HQ7 B 503 source : AC6 32) chain B residue 379 type sequence E description binding site for residue HQ7 B 503 source : AC6 33) chain B residue 400 type sequence I description binding site for residue HQ7 B 503 source : AC6

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