eF-site ID 6dz4-AB PDB Code 6dz4 Chain A, B click to enlarge Title Crystal structure of Salmonella typhimurium Tryptophan Synthase with sodium ion at the metal coordination site and (E)-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-serine at the beta-site Classification LYASE/LYASE Inhibitor Compound Tryptophan synthase alpha chain Source (TRPB_SALTY) Sequence A:  MERYENLFAQLNDRREGAFVPFVTLGDPGIEQSLKIIDTL IDAGADALELGVPFSDPLADGPTIQNANLRAFAAGVTPAQ CFEMLALIREKHPTIPIGLLMYANLVFNNGIDAFYARCEQ VGVDSVLVADVPVEESAPFRQAALRHNIAPIFICPPNADD DLLRQVASYGRGYTYLLSLPLHHLIEKLKEYHAAPALQGF GISSPEQVSAAVRAGAAGAISGSAIVKIIEKNLASPKQML AELRSFVSAMKAASR B:  TTLLNPYFGEFGGMYVPQILMPALNQLEEAFVSAQKDPEF QAQFADLLKNYAGRPTALTKCQNITAGTRTTLYLKREDLL HGGAHKTNQVLGQALLAKRMGKSEIIAETGAGQHGVASAL ASALLGLKCRIYMGAKDVERQSPNVFRMRLMGAEVIPVHS GSATLKDACNEALRDWSGSYETAHYMLGTAAGPHPYPTIV REFQRMIGEETKAQILDKEGRLPDAVIACVGGGSNAIGMF ADFINDTSVGLIGVEPGGHGIETGEHGAPLKHGRVGIYFG MKAPMMQTADGQIEESYSISAGLDFPSVGPQHAYLNSIGR ADYVSITDDEALEAFKTLCRHEGIIPALESSHALAHALKM MREQPEKEQLLVVNLSGRGDKDIFTVHDILKARGE Description Functional site 1) chain A residue 92 type sequence H description binding site for residue CL A 301 source : AC1 2) chain A residue 93 type sequence P description binding site for residue CL A 301 source : AC1 3) chain A residue 94 type sequence T description binding site for residue CL A 301 source : AC1 4) chain A residue 95 type sequence I description binding site for residue CL A 301 source : AC1 5) chain A residue 225 type sequence R description binding site for residue CL A 302 source : AC2 6) chain A residue 82 type sequence F description binding site for residue DMS A 303 source : AC3 7) chain A residue 5 type sequence E description binding site for residue DMS A 304 source : AC4 8) chain A residue 148 type sequence I description binding site for residue DMS A 304 source : AC4 9) chain A residue 149 type sequence A description binding site for residue DMS A 304 source : AC4 10) chain A residue 60 type sequence D description binding site for residue DMS A 305 source : AC5 11) chain A residue 175 type sequence Y description binding site for residue DMS A 305 source : AC5 12) chain A residue 12 type sequence N description binding site for residue DMS A 306 source : AC6 13) chain A residue 16 type sequence E description binding site for residue DMS A 306 source : AC6 14) chain B residue 86 type sequence H description binding site for residue KOU B 401 source : AC7 15) chain B residue 87 type sequence K description binding site for residue KOU B 401 source : AC7 16) chain B residue 110 type sequence T description binding site for residue KOU B 401 source : AC7 17) chain B residue 111 type sequence G description binding site for residue KOU B 401 source : AC7 18) chain B residue 112 type sequence A description binding site for residue KOU B 401 source : AC7 19) chain B residue 113 type sequence G description binding site for residue KOU B 401 source : AC7 20) chain B residue 114 type sequence Q description binding site for residue KOU B 401 source : AC7 21) chain B residue 115 type sequence H description binding site for residue KOU B 401 source : AC7 22) chain B residue 190 type sequence T description binding site for residue KOU B 401 source : AC7 23) chain B residue 232 type sequence G description binding site for residue KOU B 401 source : AC7 24) chain B residue 233 type sequence G description binding site for residue KOU B 401 source : AC7 25) chain B residue 234 type sequence G description binding site for residue KOU B 401 source : AC7 26) chain B residue 235 type sequence S description binding site for residue KOU B 401 source : AC7 27) chain B residue 236 type sequence N description binding site for residue KOU B 401 source : AC7 28) chain B residue 302 type sequence A description binding site for residue KOU B 401 source : AC7 29) chain B residue 303 type sequence G description binding site for residue KOU B 401 source : AC7 30) chain B residue 305 type sequence D description binding site for residue KOU B 401 source : AC7 31) chain B residue 350 type sequence E description binding site for residue KOU B 401 source : AC7 32) chain B residue 377 type sequence S description binding site for residue KOU B 401 source : AC7 33) chain B residue 66 type sequence T description binding site for residue NA B 402 source : AC8 34) chain B residue 69 type sequence T description binding site for residue NA B 402 source : AC8 35) chain B residue 71 type sequence T description binding site for residue NA B 402 source : AC8 36) chain B residue 232 type sequence G description binding site for residue NA B 403 source : AC9 37) chain B residue 306 type sequence F description binding site for residue NA B 403 source : AC9 38) chain B residue 308 type sequence S description binding site for residue NA B 403 source : AC9 39) chain B residue 219 type sequence K description binding site for residue CL B 405 source : AD1 40) chain B residue 220 type sequence E description binding site for residue CL B 405 source : AD1 41) chain B residue 274 type sequence G description binding site for residue CL B 406 source : AD2 42) chain A residue 224 type sequence V description binding site for residue CL B 407 source : AD3 43) chain A residue 225 type sequence R description binding site for residue CL B 407 source : AD3 44) chain A residue 138 type sequence P description binding site for residue CL B 409 source : AD4 45) chain B residue 283 type sequence K description binding site for residue CL B 409 source : AD4 46) chain B residue 42 type sequence Q description binding site for residue DMS B 410 source : AD5 47) chain B residue 46 type sequence A description binding site for residue DMS B 410 source : AD5 48) chain B residue 271 type sequence L description binding site for residue DMS B 411 source : AD6 49) chain B residue 317 type sequence N description binding site for residue DMS B 411 source : AD6 50) chain B residue 363 type sequence R description binding site for residue DMS B 411 source : AD6 51) chain B residue 364 type sequence E description binding site for residue DMS B 411 source : AD6 52) chain B residue 143 type sequence S description binding site for residue DMS B 412 source : AD7 53) chain B residue 144 type sequence P description binding site for residue DMS B 412 source : AD7 54) chain B residue 385 type sequence F description binding site for residue DMS B 412 source : AD7 55) chain B residue 388 type sequence H description binding site for residue DMS B 412 source : AD7 56) chain B residue 262 type sequence I description binding site for residue DMS B 413 source : AD8 57) chain B residue 267 type sequence H description binding site for residue DMS B 413 source : AD8 58) chain B residue 273 type sequence H description binding site for residue DMS B 413 source : AD8 59) chain B residue 36 type sequence Q description binding site for residue DMS B 414 source : AD9 60) chain B residue 37 type sequence K description binding site for residue DMS B 414 source : AD9 61) chain B residue 8 type sequence Y description binding site for residue DMS B 415 source : AE1 62) chain B residue 10 type sequence G description binding site for residue DMS B 415 source : AE1 63) chain B residue 3 type sequence T description binding site for residue DMS B 416 source : AE2 64) chain B residue 4 type sequence L description binding site for residue DMS B 416 source : AE2 65) chain B residue 5 type sequence L description binding site for residue DMS B 416 source : AE2 66) chain B residue 6 type sequence N description binding site for residue DMS B 416 source : AE2 67) chain B residue 357 type sequence H description binding site for residue DMS B 417 source : AE3 68) chain B residue 364 type sequence E description binding site for residue DMS B 417 source : AE3 69) chain B residue 87 type MOD_RES sequence K description N6-(pyridoxal phosphate)lysine source Swiss-Prot : SWS_FT_FI1 70) chain A residue 60 type MOD_RES sequence D description N6-(pyridoxal phosphate)lysine source Swiss-Prot : SWS_FT_FI1 71) chain B residue 87 type catalytic sequence K description 383 source MCSA : MCSA1 72) chain B residue 109 type catalytic sequence E description 383 source MCSA : MCSA1 73) chain B residue 377 type catalytic sequence S description 383 source MCSA : MCSA1 74) chain A residue 48-61 type prosite sequence LELGVPFSDPLADG description TRP_SYNTHASE_ALPHA Tryptophan synthase alpha chain signature. LELGvPFSDPLADG source prosite : PS00167 75) chain B residue 80-94 type prosite sequence LLHGGAHKTNQVLGQ description TRP_SYNTHASE_BETA Tryptophan synthase beta chain pyridoxal-phosphate attachment site. LlHgGAHKtNqvLgQ source prosite : PS00168

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