eF-site ID 6dz4-A PDB Code 6dz4 Chain A click to enlarge Title Crystal structure of Salmonella typhimurium Tryptophan Synthase with sodium ion at the metal coordination site and (E)-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-serine at the beta-site Classification LYASE/LYASE Inhibitor Compound Tryptophan synthase alpha chain Source (TRPB_SALTY) Sequence A:  MERYENLFAQLNDRREGAFVPFVTLGDPGIEQSLKIIDTL IDAGADALELGVPFSDPLADGPTIQNANLRAFAAGVTPAQ CFEMLALIREKHPTIPIGLLMYANLVFNNGIDAFYARCEQ VGVDSVLVADVPVEESAPFRQAALRHNIAPIFICPPNADD DLLRQVASYGRGYTYLLSLPLHHLIEKLKEYHAAPALQGF GISSPEQVSAAVRAGAAGAISGSAIVKIIEKNLASPKQML AELRSFVSAMKAASR Description Functional site 1) chain A residue 92 type sequence H description binding site for residue CL A 301 source : AC1 2) chain A residue 93 type sequence P description binding site for residue CL A 301 source : AC1 3) chain A residue 94 type sequence T description binding site for residue CL A 301 source : AC1 4) chain A residue 95 type sequence I description binding site for residue CL A 301 source : AC1 5) chain A residue 225 type sequence R description binding site for residue CL A 302 source : AC2 6) chain A residue 82 type sequence F description binding site for residue DMS A 303 source : AC3 7) chain A residue 5 type sequence E description binding site for residue DMS A 304 source : AC4 8) chain A residue 148 type sequence I description binding site for residue DMS A 304 source : AC4 9) chain A residue 149 type sequence A description binding site for residue DMS A 304 source : AC4 10) chain A residue 60 type sequence D description binding site for residue DMS A 305 source : AC5 11) chain A residue 175 type sequence Y description binding site for residue DMS A 305 source : AC5 12) chain A residue 12 type sequence N description binding site for residue DMS A 306 source : AC6 13) chain A residue 16 type sequence E description binding site for residue DMS A 306 source : AC6 14) chain A residue 224 type sequence V description binding site for residue CL B 407 source : AD3 15) chain A residue 225 type sequence R description binding site for residue CL B 407 source : AD3 16) chain A residue 138 type sequence P description binding site for residue CL B 409 source : AD4 17) chain A residue 48-61 type prosite sequence LELGVPFSDPLADG description TRP_SYNTHASE_ALPHA Tryptophan synthase alpha chain signature. LELGvPFSDPLADG source prosite : PS00167 18) chain A residue 60 type MOD_RES sequence D description N6-(pyridoxal phosphate)lysine source Swiss-Prot : SWS_FT_FI1

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