eF-site ID 6dyy-D PDB Code 6dyy Chain D click to enlarge Title Crystal structure of Helicobacter pylori 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with (3R,4S)-1-((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4-(((3-(1-butyl-1H-1,2,3-triazol-4-yl)propyl)thio)methyl)pyrrolidin-3-ol Classification HYDROLASE/HYDROLASE INHIBITOR Compound 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Source (A0A1W0VQJ9_HELPX) Sequence D:  QGVQKIGILGAMREEITPILELFGVDFEEIPLGGNVFHKG VYHNKEIIVAYSKIGKVHSTLTTTSMILAFGVQKVLFSGV AGSLVKDLKINDLLVATQLVQHDVDLSAFDHPLGFIPESA IFIETSGSLNALAKKIANEQHIALKEGVIASGDQFVHSKE RKEFLVSEFKASAVEMEGASVAFVCQKFGVPCCVLRSISD NADEKAGMSFDEFLEKSAHTSAKFLKSMVDEL Description Functional site 1) chain D residue 107 type sequence F description binding site for residue EDO A 301 source : AC1 2) chain D residue 209 type sequence D description binding site for residue EDO B 301 source : AC4 3) chain D residue 107 type sequence F description binding site for residue OS6 C 303 source : AD2 4) chain D residue 109 type sequence H description binding site for residue OS6 C 303 source : AD2 5) chain D residue 32 type sequence G description binding site for residue EDO D 301 source : AD3 6) chain D residue 33 type sequence N description binding site for residue EDO D 301 source : AD3 7) chain D residue 34 type sequence V description binding site for residue EDO D 301 source : AD3 8) chain D residue 49 type sequence Y description binding site for residue EDO D 301 source : AD3 9) chain D residue 9 type sequence A description binding site for residue OS6 D 302 source : AD4 10) chain D residue 52 type sequence I description binding site for residue OS6 D 302 source : AD4 11) chain D residue 78 type sequence V description binding site for residue OS6 D 302 source : AD4 12) chain D residue 79 type sequence A description binding site for residue OS6 D 302 source : AD4 13) chain D residue 80 type sequence G description binding site for residue OS6 D 302 source : AD4 14) chain D residue 153 type sequence F description binding site for residue OS6 D 302 source : AD4 15) chain D residue 154 type sequence V description binding site for residue OS6 D 302 source : AD4 16) chain D residue 172 type sequence V description binding site for residue OS6 D 302 source : AD4 17) chain D residue 173 type sequence E description binding site for residue OS6 D 302 source : AD4 18) chain D residue 174 type sequence M description binding site for residue OS6 D 302 source : AD4 19) chain D residue 175 type sequence E description binding site for residue OS6 D 302 source : AD4 20) chain D residue 197 type sequence S description binding site for residue OS6 D 302 source : AD4 21) chain D residue 198 type sequence D description binding site for residue OS6 D 302 source : AD4 22) chain D residue 208 type sequence F description binding site for residue OS6 D 302 source : AD4 23) chain D residue 80 type BINDING sequence G description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 24) chain D residue 154 type BINDING sequence V description source Swiss-Prot : SWS_FT_FI4 25) chain D residue 174 type BINDING sequence M description source Swiss-Prot : SWS_FT_FI4 26) chain D residue 13 type ACT_SITE sequence E description Proton acceptor => ECO:0000305|PubMed:20954236 source Swiss-Prot : SWS_FT_FI1 27) chain D residue 198 type ACT_SITE sequence D description Proton donor => ECO:0000305|PubMed:20954236 source Swiss-Prot : SWS_FT_FI2

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