eF-site ID 6dyy-B PDB Code 6dyy Chain B click to enlarge Title Crystal structure of Helicobacter pylori 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with (3R,4S)-1-((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4-(((3-(1-butyl-1H-1,2,3-triazol-4-yl)propyl)thio)methyl)pyrrolidin-3-ol Classification HYDROLASE/HYDROLASE INHIBITOR Compound 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Source (A0A1W0VQJ9_HELPX) Sequence B:  VQKIGILGAMREEITPILELFGVDFEEIPLGGNVFHKGVY HNKEIIVAYSKIGKVHSTLTTTSMILAFGVQKVLFSGVAG SLVKDLKINDLLVATQLVQHDVDLSAFDHPLGFIPESAIF IETSGSLNALAKKIANEQHIALKEGVIASGDQFVHSKERK EFLVSEFKASAVEMEGASVAFVCQKFGVPCCVLRSISDNA DEKAGMSFDEFLEKSAHTSAKFLKSMVDEL Description Functional site 1) chain B residue 109 type sequence H description binding site for residue OS6 A 303 source : AC3 2) chain B residue 115 type sequence P description binding site for residue OS6 A 303 source : AC3 3) chain B residue 116 type sequence E description binding site for residue OS6 A 303 source : AC3 4) chain B residue 123 type sequence T description binding site for residue EDO B 301 source : AC4 5) chain B residue 125 type sequence G description binding site for residue EDO B 301 source : AC4 6) chain B residue 126 type sequence S description binding site for residue EDO B 301 source : AC4 7) chain B residue 205 type sequence G description binding site for residue EDO B 302 source : AC5 8) chain B residue 206 type sequence M description binding site for residue EDO B 302 source : AC5 9) chain B residue 209 type sequence D description binding site for residue EDO B 302 source : AC5 10) chain B residue 138 type sequence Q description binding site for residue EDO B 303 source : AC6 11) chain B residue 139 type sequence H description binding site for residue EDO B 303 source : AC6 12) chain B residue 165 type sequence S description binding site for residue EDO B 303 source : AC6 13) chain B residue 166 type sequence E description binding site for residue EDO B 303 source : AC6 14) chain B residue 133 type sequence K description binding site for residue MG B 304 source : AC7 15) chain B residue 9 type sequence A description binding site for residue OS6 B 305 source : AC8 16) chain B residue 52 type sequence I description binding site for residue OS6 B 305 source : AC8 17) chain B residue 78 type sequence V description binding site for residue OS6 B 305 source : AC8 18) chain B residue 79 type sequence A description binding site for residue OS6 B 305 source : AC8 19) chain B residue 80 type sequence G description binding site for residue OS6 B 305 source : AC8 20) chain B residue 152 type sequence Q description binding site for residue OS6 B 305 source : AC8 21) chain B residue 153 type sequence F description binding site for residue OS6 B 305 source : AC8 22) chain B residue 154 type sequence V description binding site for residue OS6 B 305 source : AC8 23) chain B residue 172 type sequence V description binding site for residue OS6 B 305 source : AC8 24) chain B residue 173 type sequence E description binding site for residue OS6 B 305 source : AC8 25) chain B residue 174 type sequence M description binding site for residue OS6 B 305 source : AC8 26) chain B residue 175 type sequence E description binding site for residue OS6 B 305 source : AC8 27) chain B residue 197 type sequence S description binding site for residue OS6 B 305 source : AC8 28) chain B residue 198 type sequence D description binding site for residue OS6 B 305 source : AC8 29) chain B residue 208 type sequence F description binding site for residue OS6 B 305 source : AC8 30) chain B residue 13 type ACT_SITE sequence E description Proton acceptor => ECO:0000305|PubMed:20954236 source Swiss-Prot : SWS_FT_FI1 31) chain B residue 198 type ACT_SITE sequence D description Proton donor => ECO:0000305|PubMed:20954236 source Swiss-Prot : SWS_FT_FI2 32) chain B residue 80 type BINDING sequence G description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 33) chain B residue 154 type BINDING sequence V description source Swiss-Prot : SWS_FT_FI4 34) chain B residue 174 type BINDING sequence M description source Swiss-Prot : SWS_FT_FI4

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