eF-site ID 6dyu-B PDB Code 6dyu Chain B click to enlarge Title Crystal structure of Helicobacter pylori 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with (3R,4S)-1-((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4-((prop-2-yn-1-ylthio)methyl)pyrrolidin-3-ol Classification HYDROLASE Compound 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Source (A0A1W0VQJ9_HELPX) Sequence B:  QGVQKIGILGAMREEITPILELFGVDFEEIPLGGNVFHKG VYHNKEIIVAYSKIGKVHSTLTTTSMILAFGVQKVLFSGV AGSLVKDLKINDLLVATQLVQHDVDLSAFDHPLGFIPESA IFIETSGSLNALAKKIANEQHIALKEGVIASGDQFVHSKE RKEFLVSEFKASAVEMEGASVAFVCQKFGVPCCVLRSISD NADEKAGMSFDEFLEKSAHTSAKFLKSMVDEL Description Functional site 1) chain B residue 122 type sequence E description binding site for residue EDO B 301 source : AC4 2) chain B residue 123 type sequence T description binding site for residue EDO B 301 source : AC4 3) chain B residue 124 type sequence S description binding site for residue EDO B 301 source : AC4 4) chain B residue 184 type sequence Q description binding site for residue EDO B 301 source : AC4 5) chain B residue 188 type sequence V description binding site for residue EDO B 301 source : AC4 6) chain B residue 189 type sequence P description binding site for residue EDO B 301 source : AC4 7) chain B residue 190 type sequence C description binding site for residue EDO B 301 source : AC4 8) chain B residue 106 type sequence A description binding site for residue EDO B 303 source : AC6 9) chain B residue 206 type sequence M description binding site for residue EDO B 303 source : AC6 10) chain B residue 159 type sequence R description binding site for residue EDO B 304 source : AC7 11) chain B residue 32 type sequence G description binding site for residue EDO B 305 source : AC8 12) chain B residue 33 type sequence N description binding site for residue EDO B 305 source : AC8 13) chain B residue 34 type sequence V description binding site for residue EDO B 305 source : AC8 14) chain B residue 49 type sequence Y description binding site for residue EDO B 305 source : AC8 15) chain B residue 10 type sequence M description binding site for residue EDO B 307 source : AD1 16) chain B residue 107 type sequence F description binding site for residue EDO B 307 source : AD1 17) chain B residue 209 type sequence D description binding site for residue EDO B 307 source : AD1 18) chain B residue 213 type sequence E description binding site for residue EDO B 308 source : AD2 19) chain B residue 9 type sequence A description binding site for residue OS2 B 309 source : AD3 20) chain B residue 52 type sequence I description binding site for residue OS2 B 309 source : AD3 21) chain B residue 78 type sequence V description binding site for residue OS2 B 309 source : AD3 22) chain B residue 79 type sequence A description binding site for residue OS2 B 309 source : AD3 23) chain B residue 80 type sequence G description binding site for residue OS2 B 309 source : AD3 24) chain B residue 104 type sequence L description binding site for residue OS2 B 309 source : AD3 25) chain B residue 109 type sequence H description binding site for residue OS2 B 309 source : AD3 26) chain B residue 153 type sequence F description binding site for residue OS2 B 309 source : AD3 27) chain B residue 154 type sequence V description binding site for residue OS2 B 309 source : AD3 28) chain B residue 172 type sequence V description binding site for residue OS2 B 309 source : AD3 29) chain B residue 173 type sequence E description binding site for residue OS2 B 309 source : AD3 30) chain B residue 174 type sequence M description binding site for residue OS2 B 309 source : AD3 31) chain B residue 175 type sequence E description binding site for residue OS2 B 309 source : AD3 32) chain B residue 197 type sequence S description binding site for residue OS2 B 309 source : AD3 33) chain B residue 198 type sequence D description binding site for residue OS2 B 309 source : AD3 34) chain B residue 208 type sequence F description binding site for residue OS2 B 309 source : AD3 35) chain B residue 54 type sequence K description binding site for residue NH4 B 310 source : AD4 36) chain B residue 54 type sequence K description binding site for residue NH4 B 310 source : AD4 37) chain B residue 101 type sequence D description binding site for residue NH4 B 310 source : AD4 38) chain B residue 101 type sequence D description binding site for residue NH4 B 310 source : AD4 39) chain B residue 151 type sequence D description binding site for residue NH4 B 310 source : AD4 40) chain B residue 151 type sequence D description binding site for residue NH4 B 310 source : AD4 41) chain B residue 13 type ACT_SITE sequence E description Proton acceptor => ECO:0000305|PubMed:20954236 source Swiss-Prot : SWS_FT_FI1 42) chain B residue 198 type ACT_SITE sequence D description Proton donor => ECO:0000305|PubMed:20954236 source Swiss-Prot : SWS_FT_FI2 43) chain B residue 80 type BINDING sequence G description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 44) chain B residue 154 type BINDING sequence V description source Swiss-Prot : SWS_FT_FI4 45) chain B residue 174 type BINDING sequence M description source Swiss-Prot : SWS_FT_FI4

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