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eF-site ID
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6drd-B |
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PDB Code
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6drd |
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Chain
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B |
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click to enlarge
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Title
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RNA Pol II(G) |
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Classification
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TRANSFERASE |
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Compound
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DNA-directed RNA polymerase II subunit RPB1 |
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Source
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ORGANISM_COMMON: Human; ORGANISM_SCIENTIFIC: Homo sapiens; |
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Sequence
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B: |
EITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSV
QRIVEDAPPIDLQPPRYLLKFEQIYLSKPTHWERDGAPSP
MMPNEARLRNLTYSAPLYVDITKTVIKEGEEQLQTQHQKT
FIGKIPIMLRSTYCLLNGLTDRDLCELNECPLDPGGYFII
NGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLEN
SSRPTSTIWVSMLARGGQGAKKSAIGQRIVATLPYIKQEV
PIIIVFRALGFVSDRDILEHIIYDFEDPEMMEMVKPSLDE
AFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKEM
LPHVGVSDFCETKKAYFLGYMVHRLLLAALGRRELDDRDH
YGNKRLDLAGPLLAFLFRGMFKNLLKEVRIYAQKFIDRGK
DFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVS
QVLNRLTFASTLSHLRRLNSPIKPRQLHNTLWGMVCPAET
PEGHAVGLVKNLALMAYISVGSQPSPILEFLEEWSMENLE
EISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQM
DIIVSEVSMIRDIREREIRIYTDAGRICRPLLIVEKQKLL
LKKRHIDQLKEREYNNYSWQDLVASGVVEYIDTLEEETVM
LAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASIIPFP
DHNQSPRNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYP
QKPLVTTRSMEYLRFRELPAGINSIVAIASYTGYNQEDSV
IMNRSAVDRGFFRSVFYRSYKEQESKKDQEEVFEKPTRET
CQGMRHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLTKR
DCSTFLRTSETGIVDQVMVTLNQEGYKFCKIRVRSVRIPQ
IGDKFASRHGQKGTCGIQYRQEDMPFTCEGITPDIIINPH
AIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQK
ISNLLSDYGYHLRGNEVLYNGFTGRKITSQIFIGPTYYQR
LKHMVDDKI
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Description
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(1) |
DNA-directed RNA polymerase II subunit RPB1 (E.C.2.7.7.6,2.7.7.48), DNA-directed RNA polymerase II subunit RPB2 (E.C.2.7.7.6), DNA-directed RNA polymerase II subunit RPB3, DNA-directed RNA polymerase II subunit RPB4, DNA-directed RNA polymerases I, II, and III subunit RPABC1, DNA-directed RNA polymerases I, II, and III subunit RPABC2, DNA-directed RNA polymerase II subunit RPB7, DNA-directed RNA polymerases I, II, and III subunit RPABC3, DNA-directed RNA polymerase II subunit RPB9, DNA-directed RNA polymerases I, II, and III subunit RPABC5, DNA-directed RNA polymerase II subunit RPB11-a, DNA-directed RNA polymerases I, II, and III subunit RPABC4, Gdown1,DNA-directed RNA polymerase II subunit GRINL1A
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Functional site
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1)
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chain |
B |
| residue |
932-944 |
| type |
prosite |
| sequence |
GDKFASRHGQKGT
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| description |
RNA_POL_BETA RNA polymerases beta chain signature. GdKFASrHGQKGT
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| source |
prosite : PS01166
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2)
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chain |
B |
| residue |
942 |
| type |
BINDING |
| sequence |
K
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| description |
BINDING => ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:33558764, ECO:0007744|PDB:5IY6, ECO:0007744|PDB:7AE1
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| source |
Swiss-Prot : SWS_FT_FI3
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3)
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chain |
B |
| residue |
792 |
| type |
BINDING |
| sequence |
D
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| description |
BINDING => ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:33558764, ECO:0000269|PubMed:33558766, ECO:0000269|PubMed:33674783, ECO:0000312|PDB:7DN3, ECO:0007744|PDB:5IY6, ECO:0007744|PDB:7AE1, ECO:0007744|PDB:7D58
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| source |
Swiss-Prot : SWS_FT_FI2
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4)
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chain |
B |
| residue |
1052 |
| type |
MOD_RES |
| sequence |
K
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| description |
N6-methyllysine => ECO:0007744|PubMed:24129315
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| source |
Swiss-Prot : SWS_FT_FI6
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