eF-site ID 6drd-ABCDEFGHIJKLM PDB Code 6drd Chain A, B, C, D, E, F, G, H, I, J, K, L, M Title RNA Pol II(G) Classification TRANSFERASE Compound DNA-directed RNA polymerase II subunit RPB1 Source ORGANISM_COMMON: Human; ORGANISM_SCIENTIFIC: Homo sapiens; Sequence A:  RTVITPDPNLSIDQVGVPRSIAANMTFAEIVTPFNIDRLQ ELVRRGNSQYPGAKYIIRRIDLRFHPKPSDLHLQTGYKVE RHMCDGDIVIFMGHRVRILPWSTFRLNLEMNLHLPQSLET RAEIQELAMVPRMIVQDTLTAVRKFTKRDVFLERGEVMNL LMFLSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHINCI RTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKK SLGTSAGSLVHISYLEMGHDITRLFYSNIQTVINNWLLIE GHTIGIGDSIADSKTYQDIQNTIKKAKQDVIEVIEKAHNN ELEPTPGNTLRQTFENQVNRILNDARDKTGSSAQKSLSEY NNFKSMVVSGAKGSKINISQVIAVVGQQNVEGKRIPFGFK HRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHAMGG REGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSI NQVVQLRYGEDGLAGESVEFQNLATLKPSNKAFEKKFRFD YTNERALRRTLQEDLVKDVLSNAHIQNELEREFERMREDR EVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHINPRLPSD LHPIKVVEGVKELSKKLVIVNGDDPLSRQAQENATLLFNI HLRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAIAHP GEMVGALAAQSLGEPATQNVTLGVPRLKELINISKKPKTP SLTVFLLGQSARDAERAKDILCRLEHTTLRKVTANTAIYY DPNPQSTVVAEDQEWVNVYYEMPDFDVARISPWLLRVELD RKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLVL RIRIMNKMDDDVFLRCIESNMLTDMTLQGIEQISKVYMHL PQTDNKKKIIITEDGEFKALQEWILETDGVSLMRVLSEKD VDPVRTTSNDIVEIFTVLGIEAVRKALERELYHVISFDGS YVNYRHLALLCDTMTCRGHLMAITGCFDLLLDAEKCKYGM B:  EITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSV QRIVEDAPPIDLQPPRYLLKFEQIYLSKPTHWERDGAPSP MMPNEARLRNLTYSAPLYVDITKTVIKEGEEQLQTQHQKT FIGKIPIMLRSTYCLLNGLTDRDLCELNECPLDPGGYFII NGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLEN SSRPTSTIWVSMLARGGQGAKKSAIGQRIVATLPYIKQEV PIIIVFRALGFVSDRDILEHIIYDFEDPEMMEMVKPSLDE AFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKEM LPHVGVSDFCETKKAYFLGYMVHRLLLAALGRRELDDRDH YGNKRLDLAGPLLAFLFRGMFKNLLKEVRIYAQKFIDRGK DFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVS QVLNRLTFASTLSHLRRLNSPIKPRQLHNTLWGMVCPAET PEGHAVGLVKNLALMAYISVGSQPSPILEFLEEWSMENLE EISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQM DIIVSEVSMIRDIREREIRIYTDAGRICRPLLIVEKQKLL LKKRHIDQLKEREYNNYSWQDLVASGVVEYIDTLEEETVM LAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASIIPFP DHNQSPRNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYP QKPLVTTRSMEYLRFRELPAGINSIVAIASYTGYNQEDSV IMNRSAVDRGFFRSVFYRSYKEQESKKDQEEVFEKPTRET CQGMRHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLTKR DCSTFLRTSETGIVDQVMVTLNQEGYKFCKIRVRSVRIPQ IGDKFASRHGQKGTCGIQYRQEDMPFTCEGITPDIIINPH AIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQK ISNLLSDYGYHLRGNEVLYNGFTGRKITSQIFIGPTYYQR LKHMVDDKI C:  PYANQPTVRITELTDENVKFIIENTDLAVANSIRRVFIAE VPIIAIDWVQIDANSSVLHDEFIAHRLGLIPLISDDIVDK LQYSRDCTCEEFCPECSVEFTLDVRCNEDQTRHVTSRDLI SNSPRVIPVTSRNVEQDDILIVKLRKGQELRLRAYAKKGF GKEHAKWNPTAGVAFEYDPDNALRHTVYPKPEEWPKSEYS ELDEDESQAPYDPNGKPERFYYNVESCGSLRPETIVLSAL SGLKKKLSDLQTQLSHEIQSDV D:  EEDASQLIFPKEFETAETLLNSEVHMLLEHRKQQNESAED EQELSEVFMKTLNYTARFSRFKNRETIASVRSLLLQKKLH KFELACLANLCPETAEESKALIPSLEGRFEDEELQQILDD IQTKRSFQ E:  ETYRLWKIRKTIMQLCHDRGYLVTQDELDQTLEEFKAQTD LTVLVAHNQMFVFFPEEPKVGIKTIKVYCQRMQEENITRA LIVVQQGSAKQSLVDMAPKYILEQFLEQELLINITEHELV PEHVVMTKEEVSELLARYKLRENQLPRIQAGDPVARYFGI RRGQVVKIIRPSETAGRYITYRLVQ F:  RITTPYMTKYERARVLGTRALQIAMCAPVMPLLIAMKELK ARKIPIIIRRYLPDGSYEDWGVDELIIT G:  MFYHISLEHEILLHPRYFLNTVKQKLFTEVEGTCTGKYGF VIAVTTIDNIGAGVIQPGRGFVLYPVKYKAIVFRPFKGEV VDAVVTQVNKVGLFTEIGPMSCFISRHSIPSEMEFDPNSN PPCYKTMDEDIVIQQDDEIRLKIVGTRVDKNDIFAIGSLM DDYLGLV H:  GILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILD VNIQIYPVDLGDKFRLVIASTLYEDGTLDDGEYNPTDDRP SRADQFEYVMYGKVYRIEGDETSTEAATRLSAYVSYGGLL MRLQGDANNLHGFEVDSRVYLLMKKL I:  VGIRFCQECNNMLYPKEDKENRILLYACRNCDYQQEADNS CIYVNKITHEVDELTQIIADVSQDPTLPRTEDHPCQKCGH KEAVFFQSHSDAMRLYYVCTAPHCGHRWTE J:  MIIPVRCFTCGKIVGNKWEAYLGLLQAEYTEGDALDALGL KRYCCRRMLLAHVDLIEKLLNYAP K:  NAPPAFESFLLFEGEKKITINKDTKVPNACLFTINKEDHT LGNIIKSQLLKDPQVLFAGYKVPHPLEHKIIIRVQTTPDY SPQEAFTNAITDLISELSLLEERFRVAIKDK L:  MIYICGECHTENEICRECGYRIMYKKRTKRLVVFDAR M:  XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX XXXXXPTQLLSIEESLALQKQQ Description (1)  DNA-directed RNA polymerase II subunit RPB1 (E.C.2.7.7.6,2.7.7.48), DNA-directed RNA polymerase II subunit RPB2 (E.C.2.7.7.6), DNA-directed RNA polymerase II subunit RPB3, DNA-directed RNA polymerase II subunit RPB4, DNA-directed RNA polymerases I, II, and III subunit RPABC1, DNA-directed RNA polymerases I, II, and III subunit RPABC2, DNA-directed RNA polymerase II subunit RPB7, DNA-directed RNA polymerases I, II, and III subunit RPABC3, DNA-directed RNA polymerase II subunit RPB9, DNA-directed RNA polymerases I, II, and III subunit RPABC5, DNA-directed RNA polymerase II subunit RPB11-a, DNA-directed RNA polymerases I, II, and III subunit RPABC4, Gdown1,DNA-directed RNA polymerase II subunit GRINL1A Functional site 1) chain C residue 88 type sequence C description binding site for residue ZN C 301 source : AC1 2) chain C residue 90 type sequence C description binding site for residue ZN C 301 source : AC1 3) chain C residue 93 type sequence F description binding site for residue ZN C 301 source : AC1 4) chain C residue 94 type sequence C description binding site for residue ZN C 301 source : AC1 5) chain C residue 97 type sequence C description binding site for residue ZN C 301 source : AC1 6) chain I residue 17 type sequence C description binding site for residue ZN I 201 source : AC2 7) chain I residue 20 type sequence C description binding site for residue ZN I 201 source : AC2 8) chain I residue 39 type sequence C description binding site for residue ZN I 201 source : AC2 9) chain I residue 42 type sequence C description binding site for residue ZN I 201 source : AC2 10) chain I residue 86 type sequence C description binding site for residue ZN I 202 source : AC3 11) chain I residue 89 type sequence C description binding site for residue ZN I 202 source : AC3 12) chain I residue 114 type sequence C description binding site for residue ZN I 202 source : AC3 13) chain I residue 119 type sequence C description binding site for residue ZN I 202 source : AC3 14) chain J residue 7 type sequence C description binding site for residue ZN J 101 source : AC4 15) chain J residue 10 type sequence C description binding site for residue ZN J 101 source : AC4 16) chain J residue 44 type sequence C description binding site for residue ZN J 101 source : AC4 17) chain J residue 45 type sequence C description binding site for residue ZN J 101 source : AC4 18) chain L residue 19 type sequence C description binding site for residue ZN L 101 source : AC5 19) chain L residue 21 type sequence E description binding site for residue ZN L 101 source : AC5 20) chain L residue 22 type sequence C description binding site for residue ZN L 101 source : AC5 21) chain L residue 39 type sequence C description binding site for residue ZN L 101 source : AC5 22) chain C residue 32-72 type prosite sequence NSIRRVFIAEVPIIAIDWVQIDANSSVLHDEFIAHRLGLI P description RNA_POL_D_30KD RNA polymerases D / 30 to 40 Kd subunits signature. NSIRRvfiaevpiiAidwVqidaNsSvlhDEfIAhRLGLIP source prosite : PS00446 23) chain E residue 142-155 type prosite sequence HELVPEHVVMTKEE description RNA_POL_H_23KD RNA polymerases H / 23 Kd subunits signature. HELVPEHvvMtkEE source prosite : PS01110 24) chain K residue 35-66 type prosite sequence INKEDHTLGNIIKSQLLKDPQVLFAGYKVPHP description RNA_POL_L_13KD RNA polymerases L / 13 to 16 Kd subunits signature. InkEdHTLgNiIksqLlkdpqVlfagYkvpHP source prosite : PS01154 25) chain I residue 112-118 type prosite sequence YVCTAPH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YVCTAPH source prosite : PS00290 26) chain I residue 86-123 type prosite sequence CQKCGHKEAVFFQSHSDAMRLYYVCTAPHCGHRW description ZF_TFIIS_1 Zinc finger TFIIS-type signature. CqkCghkeavffqSHSARaEDAmrlyyvCtaph.CghrW source prosite : PS00466 27) chain I residue 16-42 type prosite sequence FCQECNNMLYPKEDKENRILLYACRNC description RNA_POL_M_15KD RNA polymerases M / 15 Kd subunits signature. FCqECNNMLypkedkenrillyaCrnC source prosite : PS01030 28) chain B residue 932-944 type prosite sequence GDKFASRHGQKGT description RNA_POL_BETA RNA polymerases beta chain signature. GdKFASrHGQKGT source prosite : PS01166 29) chain F residue 58-72 type prosite sequence TKYERARVLGTRALQ description RNA_POL_K_14KD RNA polymerases K / 14 to 18 Kd subunits signature. TkYErARvLGtRAlQ source prosite : PS01111 30) chain J residue 2-11 type prosite sequence IIPVRCFTCG description RNA_POL_N_8KD RNA polymerases N / 8 Kd subunits signature. IIPVrCFTCG source prosite : PS01112 31) chain L residue 22 type BINDING sequence C description BINDING => ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:33558764, ECO:0007744|PDB:5IY6, ECO:0007744|PDB:7AE1 source Swiss-Prot : SWS_FT_FI3 32) chain I residue 20 type BINDING sequence C description BINDING => ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:33558764, ECO:0007744|PDB:5IY6, ECO:0007744|PDB:7AE1 source Swiss-Prot : SWS_FT_FI3 33) chain I residue 39 type BINDING sequence C description BINDING => ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:33558764, ECO:0007744|PDB:5IY6, ECO:0007744|PDB:7AE1 source Swiss-Prot : SWS_FT_FI3 34) chain I residue 42 type BINDING sequence C description BINDING => ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:33558764, ECO:0007744|PDB:5IY6, ECO:0007744|PDB:7AE1 source Swiss-Prot : SWS_FT_FI3 35) chain B residue 942 type BINDING sequence K description BINDING => ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:33558764, ECO:0007744|PDB:5IY6, ECO:0007744|PDB:7AE1 source Swiss-Prot : SWS_FT_FI3 36) chain L residue 19-39 type ZN_FING sequence CGECHTENEICREC description C4-type => ECO:0000269|PubMed:33558764, ECO:0000269|PubMed:33558766, ECO:0000269|PubMed:33674783, ECO:0000312|PDB:7DN3, ECO:0007744|PDB:7AE1, ECO:0007744|PDB:7D58 source Swiss-Prot : SWS_FT_FI1 37) chain J residue 10 type ZN_FING sequence C description C4-type => ECO:0000269|PubMed:33558764, ECO:0000269|PubMed:33558766, ECO:0000269|PubMed:33674783, ECO:0000312|PDB:7DN3, ECO:0007744|PDB:7AE1, ECO:0007744|PDB:7D58 source Swiss-Prot : SWS_FT_FI1 38) chain J residue 44 type ZN_FING sequence C description C4-type => ECO:0000269|PubMed:33558764, ECO:0000269|PubMed:33558766, ECO:0000269|PubMed:33674783, ECO:0000312|PDB:7DN3, ECO:0007744|PDB:7AE1, ECO:0007744|PDB:7D58 source Swiss-Prot : SWS_FT_FI1 39) chain C residue 97 type ZN_FING sequence C description C4-type => ECO:0000269|PubMed:33558764, ECO:0000269|PubMed:33558766, ECO:0000269|PubMed:33674783, ECO:0000312|PDB:7DN3, ECO:0007744|PDB:7AE1, ECO:0007744|PDB:7D58 source Swiss-Prot : SWS_FT_FI1 40) chain L residue 19 type BINDING sequence C description BINDING => ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:33558764, ECO:0000269|PubMed:33558766, ECO:0000269|PubMed:33674783, ECO:0000312|PDB:7DN3, ECO:0007744|PDB:5IY6, ECO:0007744|PDB:7AE1, ECO:0007744|PDB:7D58 source Swiss-Prot : SWS_FT_FI2 41) chain B residue 792 type BINDING sequence D description BINDING => ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:33558764, ECO:0000269|PubMed:33558766, ECO:0000269|PubMed:33674783, ECO:0000312|PDB:7DN3, ECO:0007744|PDB:5IY6, ECO:0007744|PDB:7AE1, ECO:0007744|PDB:7D58 source Swiss-Prot : SWS_FT_FI2 42) chain L residue 36 type BINDING sequence C description BINDING => ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:33558764, ECO:0000269|PubMed:33558766, ECO:0007744|PDB:5IY6, ECO:0007744|PDB:7AE1, ECO:0007744|PDB:7D58 source Swiss-Prot : SWS_FT_FI4 43) chain I residue 89 type BINDING sequence C description BINDING => ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:33558764, ECO:0000269|PubMed:33558766, ECO:0007744|PDB:5IY6, ECO:0007744|PDB:7AE1, ECO:0007744|PDB:7D58 source Swiss-Prot : SWS_FT_FI4 44) chain I residue 114 type BINDING sequence C description BINDING => ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:33558764, ECO:0000269|PubMed:33558766, ECO:0007744|PDB:5IY6, ECO:0007744|PDB:7AE1, ECO:0007744|PDB:7D58 source Swiss-Prot : SWS_FT_FI4 45) chain I residue 119 type BINDING sequence C description BINDING => ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:33558764, ECO:0000269|PubMed:33558766, ECO:0007744|PDB:5IY6, ECO:0007744|PDB:7AE1, ECO:0007744|PDB:7D58 source Swiss-Prot : SWS_FT_FI4 46) chain L residue 39 type BINDING sequence C description BINDING => ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:33558766, ECO:0000269|PubMed:33674783, ECO:0000312|PDB:7DN3, ECO:0007744|PDB:5IY6, ECO:0007744|PDB:7D58 source Swiss-Prot : SWS_FT_FI5 47) chain B residue 1052 type MOD_RES sequence K description N6-methyllysine => ECO:0007744|PubMed:24129315 source Swiss-Prot : SWS_FT_FI6

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