eF-site ID 6dqe-A PDB Code 6dqe Chain A click to enlarge Title LINKED KDM5A JMJ DOMAIN BOUND TO THE INHIBITOR N67 i.e. 2-(5-phenyl-4-(phenyl(2-(piperidin-1-yl)ethoxy)methyl)-1H-pyrazol-1-yl)isonicotinic acid Classification OXIDOREDUCTASE/INHIBITOR Compound Linked KDM5A Jmj Domain Source (KDM5A_HUMAN) Sequence A:  AEFVPPPECPVFEPSWEEFTDPLSFIGRIRPLAEKTGICK IRPPKDWQPPFACEVKSFRFTPRVQRLNELEAMREYTLQS FGEMADNFKSDYFNMPVHMVPTELVEKEFWRLVSSIEEDV IVEYGADISSKDFGSGFPVKDGRRKILPEEEEYALSGWNL NNMPVLEQSVLAKVPWLYVGMCFSSFCWHIEDHWSYSINY LHWGEPKTWYGVPSHAAEQLEEVMRELAPELFESQPDLLH QLVTIMNPNVLMEHGVPVYRTNQCAGEFVVTFPRAYHSGF NQGYNFAEAVNFCT Description Functional site 1) chain A residue 409 type sequence Y description binding site for residue H6A A 601 source : AC1 2) chain A residue 412 type sequence D description binding site for residue H6A A 601 source : AC1 3) chain A residue 470 type sequence W description binding site for residue H6A A 601 source : AC1 4) chain A residue 472 type sequence Y description binding site for residue H6A A 601 source : AC1 5) chain A residue 480 type sequence F description binding site for residue H6A A 601 source : AC1 6) chain A residue 483 type sequence H description binding site for residue H6A A 601 source : AC1 7) chain A residue 484 type sequence I description binding site for residue H6A A 601 source : AC1 8) chain A residue 485 type sequence E description binding site for residue H6A A 601 source : AC1 9) chain A residue 501 type sequence K description binding site for residue H6A A 601 source : AC1 10) chain A residue 503 type sequence W description binding site for residue H6A A 601 source : AC1 11) chain A residue 535 type sequence Q description binding site for residue H6A A 601 source : AC1 12) chain A residue 571 type sequence H description binding site for residue H6A A 601 source : AC1 13) chain A residue 483 type sequence H description binding site for residue MN A 602 source : AC2 14) chain A residue 485 type sequence E description binding site for residue MN A 602 source : AC2 15) chain A residue 571 type sequence H description binding site for residue MN A 602 source : AC2 16) chain A residue 380 type sequence M description binding site for residue GOL A 603 source : AC3 17) chain A residue 381 type sequence P description binding site for residue GOL A 603 source : AC3 18) chain A residue 485 type sequence E description binding site for residue GOL A 603 source : AC3 19) chain A residue 486 type sequence D description binding site for residue GOL A 603 source : AC3 20) chain A residue 487 type sequence H description binding site for residue GOL A 603 source : AC3 21) chain A residue 488 type sequence W description binding site for residue GOL A 603 source : AC3 22) chain A residue 531 type sequence D description binding site for residue DMS A 604 source : AC4 23) chain A residue 534 type sequence H description binding site for residue DMS A 604 source : AC4 24) chain A residue 570 type sequence Y description binding site for residue DMS A 604 source : AC4 25) chain A residue 470 type sequence W description binding site for residue DMS A 605 source : AC5 26) chain A residue 472 type sequence Y description binding site for residue DMS A 605 source : AC5 27) chain A residue 485 type sequence E description binding site for residue DMS A 605 source : AC5 28) chain A residue 585 type sequence N description binding site for residue DMS A 605 source : AC5 29) chain A residue 384 type sequence M description binding site for residue DMS A 606 source : AC6 30) chain A residue 508 type sequence S description binding site for residue DMS A 606 source : AC6 31) chain A residue 451 type CROSSLNK sequence L description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI6

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