eF-site ID 6dq7-A PDB Code 6dq7 Chain A click to enlarge Title LINKED KDM5A JMJ DOMAIN BOUND TO THE POTENTIAL HYDROLYSIS PRODUCT OF INHIBITOR N45 i.e. 3-((6-(4-(2-cyano-3-methylbut-2-enoyl)-1,4-diazepan-1-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoic acid Classification OXIDOREDUCTASE/INHIBITOR Compound Linked KDM5A Jmj Domain Source (KDM5A_HUMAN) Sequence A:  AEFVPPPECPVFEPSWEEFTDPLSFIGRIRPLAEKTGICK IRPPKDWQPPFACEVKSFRFTPRVQRLNELEAMTVREYTL QSFGEMADNFKSDYFNMPVHMVPTELVEKEFWRLVSSIEE DVIVEYGADISSKDFGSGFPVKDGRRKILPEEEEYALSGW NLNNMPVLEQSVKVPWLYVGMCFSSFCWHIEDHWSYSINY LHWGEPKTWYGVPSHAAEQLEEVMRELAPELFESQPDLLH QLVTIMNPNVLMEHGVPVYRTNQCAGEFVVTFPRAYHSGF NQGYNFAEAVNFCT Description Functional site 1) chain A residue 73 type sequence R description binding site for residue H6M A 601 source : AC1 2) chain A residue 409 type sequence Y description binding site for residue H6M A 601 source : AC1 3) chain A residue 411 type sequence A description binding site for residue H6M A 601 source : AC1 4) chain A residue 412 type sequence D description binding site for residue H6M A 601 source : AC1 5) chain A residue 472 type sequence Y description binding site for residue H6M A 601 source : AC1 6) chain A residue 479 type sequence S description binding site for residue H6M A 601 source : AC1 7) chain A residue 480 type sequence F description binding site for residue H6M A 601 source : AC1 8) chain A residue 481 type sequence C description binding site for residue H6M A 601 source : AC1 9) chain A residue 483 type sequence H description binding site for residue H6M A 601 source : AC1 10) chain A residue 485 type sequence E description binding site for residue H6M A 601 source : AC1 11) chain A residue 486 type sequence D description binding site for residue H6M A 601 source : AC1 12) chain A residue 493 type sequence N description binding site for residue H6M A 601 source : AC1 13) chain A residue 501 type sequence K description binding site for residue H6M A 601 source : AC1 14) chain A residue 535 type sequence Q description binding site for residue H6M A 601 source : AC1 15) chain A residue 483 type sequence H description binding site for residue MN A 602 source : AC2 16) chain A residue 485 type sequence E description binding site for residue MN A 602 source : AC2 17) chain A residue 50 type sequence K description binding site for residue EDO A 603 source : AC3 18) chain A residue 52 type sequence R description binding site for residue EDO A 603 source : AC3 19) chain A residue 556 type sequence N description binding site for residue EDO A 603 source : AC3 20) chain A residue 380 type sequence M description binding site for residue GOL A 604 source : AC4 21) chain A residue 381 type sequence P description binding site for residue GOL A 604 source : AC4 22) chain A residue 485 type sequence E description binding site for residue GOL A 604 source : AC4 23) chain A residue 486 type sequence D description binding site for residue GOL A 604 source : AC4 24) chain A residue 487 type sequence H description binding site for residue GOL A 604 source : AC4 25) chain A residue 451 type CROSSLNK sequence L description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI6

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