eF-site ID 6dn8-ACEF PDB Code 6dn8 Chain A, C, E, F click to enlarge Title SPRY domain-containing SOCS box protein 2 complexed with (GZJ)VDINNN(CY3) Cyclic peptide inhibitor Classification IMMUNE SYSTEM/INHIBITOR Compound SPRY domain-containing SOCS box protein 4 Source (6DN8) Sequence A:  RPARLDQLLDMPAAGLAVQLRHAWNPEDRSLNVFVKDDDR LTFHRHPVAQSTDGIRGKVGHARGLHAWQINWPARQRGTH AVVGVATARAPLHSVGYTALVGSDAESWGWDLGRSRLYHD GKNQPGVAYPAFLFALPDSLLVVLDMDEGTLSFIVDGQYL GVAFRGLKGKKLYPVVSAVWGHCEVTMRYINGLDP C:  ARLDQLLDMPAAGLAVQLRHAWNPEDRSLNVFVKDDDRLT FHRHPVAQSTDGIRGKVGHARGLHAWQINWPARQRGTHAV VGVATARAPLHSVGYTALVGSDAESWGWDLGRSRLYHDGK NQPGVAYPAFLGPDEAFALPDSLLVVLDMDEGTLSFIVDG QYLGVAFRGLKGKKLYPVVSAVWGHCEVTMRYINGLDP E:  RPARLDQLLDMPAAGLAVQLRHAWNPEDRSLNVFVKDDDR LTFHRHPVAQSTDGIRGKVGHARGLHAWQINWPARQRGTH AVVGVATARAPLHSVGYTALVGSDAESWGWDLGRSRLYHD GKNQPGVAYPAFEAFALPDSLLVVLDMDEGTLSFIVDGQY LGVAFRGLKGKKLYPVVSAVWGHCEVTMRYINGLDP F:  VDINNNX Description Functional site 1) chain A residue 62 type sequence S description binding site for residue ACT A 301 source : AC1 2) chain A residue 63 type sequence L description binding site for residue ACT A 301 source : AC1 3) chain A residue 125 type sequence H description binding site for residue ACT A 301 source : AC1 4) chain C residue 101 type sequence Q description binding site for residue ACT A 301 source : AC1 5) chain A residue 148 type sequence R description binding site for residue SO4 A 302 source : AC2 6) chain A residue 150 type sequence Y description binding site for residue SO4 A 302 source : AC2 7) chain A residue 157 type sequence P description binding site for residue SO4 A 302 source : AC2 8) chain A residue 158 type sequence G description binding site for residue SO4 A 302 source : AC2 9) chain C residue 207 type sequence K description binding site for residue SO4 A 302 source : AC2 10) chain C residue 121 type sequence R description binding site for residue ACT C 301 source : AC3 11) chain C residue 207 type sequence K description binding site for residue ACT C 301 source : AC3 12) chain C residue 208 type sequence K description binding site for residue ACT C 301 source : AC3 13) chain C residue 53 type sequence R description binding site for residue SO4 C 302 source : AC4 14) chain C residue 54 type sequence H description binding site for residue SO4 C 302 source : AC4 15) chain C residue 76 type sequence H description binding site for residue SO4 C 303 source : AC5 16) chain C residue 76 type sequence H description binding site for residue SO4 C 303 source : AC5 17) chain C residue 219 type sequence H description binding site for residue SO4 C 303 source : AC5 18) chain C residue 219 type sequence H description binding site for residue SO4 C 303 source : AC5 19) chain E residue 50 type sequence V description binding site for residue ACT E 301 source : AC6 20) chain E residue 53 type sequence R description binding site for residue ACT E 301 source : AC6 21) chain E residue 54 type sequence H description binding site for residue ACT E 301 source : AC6 22) chain A residue 185 type sequence E description binding site for residues CY3 B 101 and GZJ B 1 source : AC7 23) chain A residue 231 type sequence D description binding site for Di-peptide CY3 D 101 and ASN D 7 source : AC9 24) chain C residue 77 type sequence R description binding site for Di-peptide CY3 D 101 and ASN D 7 source : AC9 25) chain C residue 79 type sequence P description binding site for Di-peptide CY3 D 101 and ASN D 7 source : AC9 26) chain C residue 80 type sequence V description binding site for Di-peptide CY3 D 101 and ASN D 7 source : AC9 27) chain C residue 81 type sequence A description binding site for Di-peptide CY3 D 101 and ASN D 7 source : AC9 28) chain C residue 129 type sequence Y description binding site for Di-peptide CY3 D 101 and ASN D 7 source : AC9 29) chain C residue 216 type sequence V description binding site for Di-peptide CY3 D 101 and ASN D 7 source : AC9 30) chain C residue 218 type sequence G description binding site for Di-peptide CY3 D 101 and ASN D 7 source : AC9 31) chain A residue 231 type sequence D description binding site for residues CY3 D 101 and GZJ D 1 source : AD1 32) chain E residue 77 type sequence R description binding site for Di-peptide CY3 F 101 and ASN F 7 source : AD2 33) chain E residue 79 type sequence P description binding site for Di-peptide CY3 F 101 and ASN F 7 source : AD2 34) chain E residue 80 type sequence V description binding site for Di-peptide CY3 F 101 and ASN F 7 source : AD2 35) chain E residue 81 type sequence A description binding site for Di-peptide CY3 F 101 and ASN F 7 source : AD2 36) chain E residue 129 type sequence Y description binding site for Di-peptide CY3 F 101 and ASN F 7 source : AD2 37) chain E residue 216 type sequence V description binding site for Di-peptide CY3 F 101 and ASN F 7 source : AD2 38) chain E residue 218 type sequence G description binding site for Di-peptide CY3 F 101 and ASN F 7 source : AD2 39) chain F residue 2 type sequence V description binding site for Di-peptide CY3 F 101 and ASN F 7 source : AD2 40) chain F residue 3 type sequence D description binding site for Di-peptide CY3 F 101 and ASN F 7 source : AD2 41) chain F residue 5 type sequence N description binding site for Di-peptide CY3 F 101 and ASN F 7 source : AD2 42) chain F residue 6 type sequence N description binding site for Di-peptide CY3 F 101 and ASN F 7 source : AD2 43) chain A residue 130-144 type prosite sequence TALVGSDAESWGWDL description WD_REPEATS_1 Trp-Asp (WD) repeats signature. TALVgsDaESWGWDL source prosite : PS00678

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