|
|
eF-site ID
|
6dn0-C |
|
PDB Code
|
6dn0 |
|
Chain
|
C |
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click to enlarge
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Title
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Retrofitted antibodies with stabilizing mutations: Herceptin scFv mutant with VH K30D and VL S52D. |
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Classification
|
IMMUNE SYSTEM |
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Compound
|
Human Variable Heavy Chain of Herceptin containing VH mutation K30D |
|
Source
|
(6DN0) |
|
|
Sequence
|
C: |
EVQLVESGGGLVQPGGSLRLSCAASGFNIDDTYIHWVRQA
PGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAY
LQMNSLRAEDTAVYYCSRWGFYAMDVWGQGTLVTVS
|
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Description
|
|
Functional site
|
|
|
1)
|
chain |
C |
| residue |
19 |
| type |
|
| sequence |
R
|
| description |
binding site for residue FMT A 201
|
| source |
: AC1
|
|
|
2)
|
chain |
C |
| residue |
50 |
| type |
|
| sequence |
R
|
| description |
binding site for residue FMT C 201
|
| source |
: AC4
|
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|
|