eF-site ID 6dn0-ABCD PDB Code 6dn0 Chain A, B, C, D click to enlarge Title Retrofitted antibodies with stabilizing mutations: Herceptin scFv mutant with VH K30D and VL S52D. Classification IMMUNE SYSTEM Compound Human Variable Heavy Chain of Herceptin containing VH mutation K30D Source (6DN0) Sequence A:  EVQLVESGGGLVQPGGSLRLSCAASGFNIDDTYIHWVRQA PGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAY LQMNSLRAEDTAVYYCSRWGGDGFYAMDVWGQGTLVTVS B:  DIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKP GKAPKLLIYSADFLYSGVPSRFSGSRSGTDFTLTISSLQP EDFATYYCQQHYTTPPTFGQGTKVEI C:  EVQLVESGGGLVQPGGSLRLSCAASGFNIDDTYIHWVRQA PGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAY LQMNSLRAEDTAVYYCSRWGFYAMDVWGQGTLVTVS D:  DIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKP GKAPKLLIYSADFLYSGVPSRFSGSRSGTDFTLTISSLQP EDFATYYCQQHYTTPPTFGQGTKVEI Description Functional site 1) chain A residue 50 type sequence R description binding site for residue FMT A 201 source : AC1 2) chain A residue 58 type sequence T description binding site for residue FMT A 201 source : AC1 3) chain A residue 59 type sequence R description binding site for residue FMT A 201 source : AC1 4) chain A residue 104 type sequence F description binding site for residue FMT A 201 source : AC1 5) chain C residue 19 type sequence R description binding site for residue FMT A 201 source : AC1 6) chain A residue 27 type sequence F description binding site for residue FMT A 202 source : AC2 7) chain A residue 31 type sequence D description binding site for residue FMT A 202 source : AC2 8) chain A residue 32 type sequence T description binding site for residue FMT A 202 source : AC2 9) chain A residue 98 type sequence R description binding site for residue FMT A 202 source : AC2 10) chain A residue 45 type sequence L description binding site for residue FMT B 201 source : AC3 11) chain A residue 47 type sequence W description binding site for residue FMT B 201 source : AC3 12) chain B residue 97 type sequence T description binding site for residue FMT B 201 source : AC3 13) chain B residue 98 type sequence F description binding site for residue FMT B 201 source : AC3 14) chain C residue 50 type sequence R description binding site for residue FMT C 201 source : AC4 15) chain D residue 94 type sequence T description binding site for residue FMT C 201 source : AC4

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