eF-site ID 6dkw-B PDB Code 6dkw Chain B click to enlarge Title Crystal structure of Trk-A in complex with the Pan-Trk Kinase Inhibitor, compound 3. Classification TRANSFERASE/TRANSFERASE INHIBITOR Compound Tyrosine-protein kinase receptor Source (J3KP20_HUMAN) Sequence B:  LVPRGSVHHIKRRDIVLKWELGEGKVFLAECHNLLPEQDK MLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGV CTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKGPLGLGQLL AVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGD FGTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYG KQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCW QREPQQRHSIKDVHARLQALAQAPPVYLD Description Functional site 1) chain B residue 516 type sequence L description binding site for residue GXA B 801 source : AC2 2) chain B residue 542 type sequence A description binding site for residue GXA B 801 source : AC2 3) chain B residue 564 type sequence L description binding site for residue GXA B 801 source : AC2 4) chain B residue 567 type sequence L description binding site for residue GXA B 801 source : AC2 5) chain B residue 573 type sequence V description binding site for residue GXA B 801 source : AC2 6) chain B residue 589 type sequence F description binding site for residue GXA B 801 source : AC2 7) chain B residue 590 type sequence E description binding site for residue GXA B 801 source : AC2 8) chain B residue 591 type sequence Y description binding site for residue GXA B 801 source : AC2 9) chain B residue 592 type sequence M description binding site for residue GXA B 801 source : AC2 10) chain B residue 593 type sequence R description binding site for residue GXA B 801 source : AC2 11) chain B residue 595 type sequence G description binding site for residue GXA B 801 source : AC2 12) chain B residue 641 type sequence L description binding site for residue GXA B 801 source : AC2 13) chain B residue 648 type sequence H description binding site for residue GXA B 801 source : AC2 14) chain B residue 666 type sequence I description binding site for residue GXA B 801 source : AC2 15) chain B residue 667 type sequence G description binding site for residue GXA B 801 source : AC2 16) chain B residue 668 type sequence D description binding site for residue GXA B 801 source : AC2 17) chain B residue 650 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 source Swiss-Prot : SWS_FT_FI1 18) chain B residue 516 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 19) chain B residue 544 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 20) chain B residue 791 type SITE sequence Y description Interaction with PLCG1 source Swiss-Prot : SWS_FT_FI3 21) chain B residue 791 type MOD_RES sequence Y description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:15488758, ECO:0000269|PubMed:7510697, ECO:0000269|PubMed:8155326 source Swiss-Prot : SWS_FT_FI6

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