eF-site ID 6dkw-AB
PDB Code 6dkw
Chain A, B

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Title Crystal structure of Trk-A in complex with the Pan-Trk Kinase Inhibitor, compound 3.
Classification TRANSFERASE/TRANSFERASE INHIBITOR
Compound Tyrosine-protein kinase receptor
Source (J3KP20_HUMAN)
Sequence A:  MHHHHHHLVPRGSVHHIKRRDIVLKWELGEGAFGKVFLAE
CHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQ
HQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDA
KLLAGGEDGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDL
ATRNCLVGQGLVVKIGDFGLPIRWMPPESILYRKFTTESD
VWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERP
RACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPP
VYLD
B:  LVPRGSVHHIKRRDIVLKWELGEGKVFLAECHNLLPEQDK
MLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGV
CTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKGPLGLGQLL
AVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGD
FGTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYG
KQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCW
QREPQQRHSIKDVHARLQALAQAPPVYLD
Description


Functional site

1) chain A
residue 524
type
sequence V
description binding site for residue GXA A 801
source : AC1

2) chain A
residue 542
type
sequence A
description binding site for residue GXA A 801
source : AC1

3) chain A
residue 564
type
sequence L
description binding site for residue GXA A 801
source : AC1

4) chain A
residue 567
type
sequence L
description binding site for residue GXA A 801
source : AC1

5) chain A
residue 572
type
sequence I
description binding site for residue GXA A 801
source : AC1

6) chain A
residue 573
type
sequence V
description binding site for residue GXA A 801
source : AC1

7) chain A
residue 589
type
sequence F
description binding site for residue GXA A 801
source : AC1

8) chain A
residue 590
type
sequence E
description binding site for residue GXA A 801
source : AC1

9) chain A
residue 591
type
sequence Y
description binding site for residue GXA A 801
source : AC1

10) chain A
residue 592
type
sequence M
description binding site for residue GXA A 801
source : AC1

11) chain A
residue 593
type
sequence R
description binding site for residue GXA A 801
source : AC1

12) chain A
residue 595
type
sequence G
description binding site for residue GXA A 801
source : AC1

13) chain A
residue 641
type
sequence L
description binding site for residue GXA A 801
source : AC1

14) chain A
residue 646
type
sequence F
description binding site for residue GXA A 801
source : AC1

15) chain A
residue 648
type
sequence H
description binding site for residue GXA A 801
source : AC1

16) chain A
residue 657
type
sequence L
description binding site for residue GXA A 801
source : AC1

17) chain A
residue 666
type
sequence I
description binding site for residue GXA A 801
source : AC1

18) chain A
residue 667
type
sequence G
description binding site for residue GXA A 801
source : AC1

19) chain A
residue 668
type
sequence D
description binding site for residue GXA A 801
source : AC1

20) chain B
residue 516
type
sequence L
description binding site for residue GXA B 801
source : AC2

21) chain B
residue 542
type
sequence A
description binding site for residue GXA B 801
source : AC2

22) chain B
residue 564
type
sequence L
description binding site for residue GXA B 801
source : AC2

23) chain B
residue 567
type
sequence L
description binding site for residue GXA B 801
source : AC2

24) chain B
residue 573
type
sequence V
description binding site for residue GXA B 801
source : AC2

25) chain B
residue 589
type
sequence F
description binding site for residue GXA B 801
source : AC2

26) chain B
residue 590
type
sequence E
description binding site for residue GXA B 801
source : AC2

27) chain B
residue 591
type
sequence Y
description binding site for residue GXA B 801
source : AC2

28) chain B
residue 592
type
sequence M
description binding site for residue GXA B 801
source : AC2

29) chain B
residue 593
type
sequence R
description binding site for residue GXA B 801
source : AC2

30) chain B
residue 595
type
sequence G
description binding site for residue GXA B 801
source : AC2

31) chain B
residue 641
type
sequence L
description binding site for residue GXA B 801
source : AC2

32) chain B
residue 648
type
sequence H
description binding site for residue GXA B 801
source : AC2

33) chain B
residue 666
type
sequence I
description binding site for residue GXA B 801
source : AC2

34) chain B
residue 667
type
sequence G
description binding site for residue GXA B 801
source : AC2

35) chain B
residue 668
type
sequence D
description binding site for residue GXA B 801
source : AC2

36) chain A
residue 650
type ACT_SITE
sequence D
description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028
source Swiss-Prot : SWS_FT_FI1

37) chain B
residue 650
type ACT_SITE
sequence D
description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028
source Swiss-Prot : SWS_FT_FI1

38) chain A
residue 516
type BINDING
sequence L
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
source Swiss-Prot : SWS_FT_FI2

39) chain A
residue 544
type BINDING
sequence K
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
source Swiss-Prot : SWS_FT_FI2

40) chain B
residue 516
type BINDING
sequence L
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
source Swiss-Prot : SWS_FT_FI2

41) chain B
residue 544
type BINDING
sequence K
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
source Swiss-Prot : SWS_FT_FI2

42) chain A
residue 791
type SITE
sequence Y
description Interaction with PLCG1
source Swiss-Prot : SWS_FT_FI3

43) chain B
residue 791
type SITE
sequence Y
description Interaction with PLCG1
source Swiss-Prot : SWS_FT_FI3

44) chain A
residue 516-544
type prosite
sequence LGEGAFGKVFLAECHNLLPEQDKMLVAVK
description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGAFGKVFlAechnllpeqdkml.....VAVK
source prosite : PS00107

45) chain A
residue 646-658
type prosite
sequence FVHRDLATRNCLV
description PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FVHrDLATRNCLV
source prosite : PS00109

46) chain A
residue 791
type MOD_RES
sequence Y
description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:15488758, ECO:0000269|PubMed:7510697, ECO:0000269|PubMed:8155326
source Swiss-Prot : SWS_FT_FI6

47) chain B
residue 791
type MOD_RES
sequence Y
description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:15488758, ECO:0000269|PubMed:7510697, ECO:0000269|PubMed:8155326
source Swiss-Prot : SWS_FT_FI6


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