eF-site ID 6dki-A PDB Code 6dki Chain A click to enlarge Title Crystal structure of Trk-A in complex with the Pan-Trk Kinase Inhibitor, compound 19. Classification TRANSFERASE/TRANSFERASE INHIBITOR Compound High affinity nerve growth factor receptor Source (NTRK1_HUMAN) Sequence A:  ACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKM LVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVC TEGRPLLMVFEYMRHGDLNRFLRSHGPDGPLGLGQLLAVA SQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGR DIYSTDYYRTMLPIRWMPPESILYRKFTTESDVWSFGVVL WEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVY AIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG Description Functional site 1) chain A residue 513 type sequence K description binding site for residue 22L A 801 source : AC1 2) chain A residue 514 type sequence W description binding site for residue 22L A 801 source : AC1 3) chain A residue 515 type sequence E description binding site for residue 22L A 801 source : AC1 4) chain A residue 525 type sequence F description binding site for residue 22L A 801 source : AC1 5) chain A residue 545 type sequence A description binding site for residue 22L A 801 source : AC1 6) chain A residue 547 type sequence K description binding site for residue 22L A 801 source : AC1 7) chain A residue 524 type sequence V description binding site for residue GOD A 802 source : AC2 8) chain A residue 542 type sequence A description binding site for residue GOD A 802 source : AC2 9) chain A residue 564 type sequence L description binding site for residue GOD A 802 source : AC2 10) chain A residue 567 type sequence L description binding site for residue GOD A 802 source : AC2 11) chain A residue 589 type sequence F description binding site for residue GOD A 802 source : AC2 12) chain A residue 590 type sequence E description binding site for residue GOD A 802 source : AC2 13) chain A residue 592 type sequence M description binding site for residue GOD A 802 source : AC2 14) chain A residue 641 type sequence L description binding site for residue GOD A 802 source : AC2 15) chain A residue 657 type sequence L description binding site for residue GOD A 802 source : AC2 16) chain A residue 666 type sequence I description binding site for residue GOD A 802 source : AC2 17) chain A residue 667 type sequence G description binding site for residue GOD A 802 source : AC2 18) chain A residue 668 type sequence D description binding site for residue GOD A 802 source : AC2 19) chain A residue 669 type sequence F description binding site for residue GOD A 802 source : AC2 20) chain A residue 594 type MOD_RES sequence H description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:15488758, ECO:0000269|PubMed:27676246, ECO:0000269|PubMed:8155326 source Swiss-Prot : SWS_FT_FI7 21) chain A residue 748 type ACT_SITE sequence R description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 source Swiss-Prot : SWS_FT_FI2 22) chain A residue 584 type SITE sequence P description Breakpoint for translocation to form TRK-T1 source Swiss-Prot : SWS_FT_FI5 23) chain A residue 594 type SITE sequence H description Interaction with SHC1 source Swiss-Prot : SWS_FT_FI6 24) chain A residue 522-537 type TRANSMEM sequence GKVFLAECHNLLPEQD description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 25) chain A residue 642 type BINDING sequence A description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI3 26) chain A residue 774 type MOD_RES sequence I description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:8155326 source Swiss-Prot : SWS_FT_FI8 27) chain A residue 778 type MOD_RES sequence H description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:15488758, ECO:0000269|PubMed:8155326 source Swiss-Prot : SWS_FT_FI9 28) chain A residue 779 type MOD_RES sequence A description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:15488758, ECO:0000269|PubMed:8155326 source Swiss-Prot : SWS_FT_FI9 29) chain A residue 516-544 type prosite sequence LGEGAFGKVFLAECHNLLPEQDKMLVAVK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGAFGKVFlAechnllpeqdkml.....VAVK source prosite : PS00107 30) chain A residue 646-658 type prosite sequence FVHRDLATRNCLV description PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FVHrDLATRNCLV source prosite : PS00109 31) chain A residue 674-682 type prosite sequence DIYSTDYYR description RECEPTOR_TYR_KIN_II Receptor tyrosine kinase class II signature. DIYstdYYR source prosite : PS00239

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