eF-site ID 6dha-B PDB Code 6dha Chain B click to enlarge Title Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with Hydroxy Pioglitazone (M-IV) Classification transcription/transcription inhibitor Compound Peroxisome proliferator-activated receptor gamma Source (PPARG_HUMAN) Sequence B:  ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSP FVIYDMNSLMMGEDKIKFKHITEVAIRIFQGCQFRSVEAV QEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASL MNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVK FNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNL LQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLL QVIKKTETDMSLHPLLQEIYKDL Description Functional site 1) chain B residue 249 type sequence I description binding site for residue GFV B 501 source : AC4 2) chain B residue 255 type sequence L description binding site for residue GFV B 501 source : AC4 3) chain B residue 259 type sequence E description binding site for residue GFV B 501 source : AC4 4) chain B residue 264 type sequence F description binding site for residue GFV B 501 source : AC4 5) chain B residue 266 type sequence H description binding site for residue GFV B 501 source : AC4 6) chain B residue 267 type sequence I description binding site for residue GFV B 501 source : AC4 7) chain B residue 280 type sequence R description binding site for residue GFV B 501 source : AC4 8) chain B residue 281 type sequence I description binding site for residue GFV B 501 source : AC4 9) chain B residue 285 type sequence C description binding site for residue GFV B 501 source : AC4 10) chain B residue 288 type sequence R description binding site for residue GFV B 501 source : AC4 11) chain B residue 292 type sequence A description binding site for residue GFV B 501 source : AC4 12) chain B residue 326 type sequence I description binding site for residue GFV B 501 source : AC4 13) chain B residue 330 type sequence L description binding site for residue GFV B 501 source : AC4 14) chain B residue 341 type sequence I description binding site for residue GFV B 501 source : AC4 15) chain B residue 348 type sequence M description binding site for residue GFV B 501 source : AC4 16) chain B residue 449 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 17) chain B residue 473 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 18) chain B residue 286 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 19) chain B residue 323 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 20) chain B residue 224 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649 source Swiss-Prot : SWS_FT_FI2

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