eF-site ID 6dg5-ABC
PDB Code 6dg5
Chain A, B, C

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Title Structure of a de novo designed Interleukin-2/Interleukin-15 mimetic complex with IL-2Rb and IL-2Rg
Classification BIOSYNTHETIC PROTEIN/Protein Binding
Compound Neoleukin-2/15
Source (IL2RG_MOUSE)
Sequence A:  PKKKIQLHAEHALYDALMILNIVKTKLEDYAFNFELILEE
IARLFESGDQKDEAEKAKRMKEWMKRIKTTASEDEQEEMA
NAIITILQSWIFS
B:  AVKNCSHLECFYNSRANVSCMWSHLNVTTCHVHAKSNLRH
WNKTCELTLVRQASWACNLILGSFPESQSLTSVDLLDINV
VCWEEKGWRRVKTCDFHPFDNLRLVAPHSLQVLHIDTQRC
NISWKVSQVSHYIEPYLEFEARRRLLGHSWEDASVLSLKQ
RQQWLFLEMLIPSTSYEVQVRVKAQRNNTGTWSPWSQPLT
FRTRPA
C:  PLPEVQCFVFNIEYMNCTWNSSSEPQATNLTLHYRYKVSD
NNTFQECSHYLFSKEITSGCQIQKEDIQLYQTFVVQLQDP
QKPQRRAVQKLNLQNLVIPRAPENLTLSNLSESQLELRWK
SRHIKERCLQYLVQYRSNRDRSWTELIVNHEPRFSLPSVD
ELKRYTFRVRSRYNPICGSSQQWSKWSQPVHWG
Description


Functional site
1) chain C
residue 71
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI1
2) chain C
residue 75
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI1
3) chain C
residue 84
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI1
4) chain C
residue 96
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI1
5) chain C
residue 159
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI1
6) chain C
residue 164
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI1
7) chain C
residue 214-247
type prosite
sequence VDELKRYTFRVRSRYNPICGSSQQWSKWSQPVHW
description HEMATOPO_REC_S_F1 Short hematopoietin receptor family 1 signature. VdelkrytfrVRsrynpicgssqq........WSkWSqpvhW
source prosite : PS01355
8) chain B
residue 199-230
type prosite
sequence LIPSTSYEVQVRVKAQRNNTGTWSPWSQPLTF
description HEMATOPO_REC_S_F1 Short hematopoietin receptor family 1 signature. VdelkrytfrVRsrynpicgssqq........WSkWSqpvhW
source prosite : PS01355

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