eF-site ID 6dfn-D PDB Code 6dfn Chain D click to enlarge Title Crystal structure of estrogen receptor alpha in complex with receptor degrader 16aa Classification NUCLEAR PROTEIN Compound Estrogen receptor Source (ESR1_HUMAN) Sequence D:  LALSLTADQMVSALLDAEPPILYSEYSMMGLLTNLADREL VHMINWAKRVPGFVDLTSHDQVHLLECAWLEILMIGLVWR SMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSR FRMMNLQGEEFVCLKSIILLNSGVYTKSLEEKDHIHRVLD KITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNK GMEHLYSMVPSYDLLLEMLDA Description Functional site 1) chain D residue 346 type sequence L description binding site for residue G9J D 601 source : AC8 2) chain D residue 347 type sequence T description binding site for residue G9J D 601 source : AC8 3) chain D residue 353 type sequence E description binding site for residue G9J D 601 source : AC8 4) chain D residue 387 type sequence L description binding site for residue G9J D 601 source : AC8 5) chain D residue 394 type sequence R description binding site for residue G9J D 601 source : AC8 6) chain D residue 421 type sequence M description binding site for residue G9J D 601 source : AC8 7) chain D residue 521 type sequence G description binding site for residue G9J D 601 source : AC8 8) chain D residue 524 type sequence H description binding site for residue G9J D 601 source : AC8 9) chain D residue 346 type sequence L description binding site for residue G91 D 602 source : AC9 10) chain D residue 347 type sequence T description binding site for residue G91 D 602 source : AC9 11) chain D residue 349 type sequence L description binding site for residue G91 D 602 source : AC9 12) chain D residue 350 type sequence A description binding site for residue G91 D 602 source : AC9 13) chain D residue 351 type sequence D description binding site for residue G91 D 602 source : AC9 14) chain D residue 353 type sequence E description binding site for residue G91 D 602 source : AC9 15) chain D residue 391 type sequence L description binding site for residue G91 D 602 source : AC9 16) chain D residue 394 type sequence R description binding site for residue G91 D 602 source : AC9 17) chain D residue 424 type sequence I description binding site for residue G91 D 602 source : AC9 18) chain D residue 428 type sequence L description binding site for residue G91 D 602 source : AC9 19) chain D residue 524 type sequence H description binding site for residue G91 D 602 source : AC9 20) chain D residue 525 type sequence L description binding site for residue G91 D 602 source : AC9 21) chain D residue 534 type sequence V description binding site for residue G91 D 602 source : AC9 22) chain D residue 322 type sequence A description binding site for residue GOL D 603 source : AD1 23) chain D residue 356 type sequence H description binding site for residue GOL D 603 source : AD1 24) chain D residue 363 type sequence R description binding site for residue GOL D 603 source : AD1 25) chain D residue 353 type BINDING sequence E description BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE source Swiss-Prot : SWS_FT_FI1 26) chain D residue 394 type BINDING sequence R description BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE source Swiss-Prot : SWS_FT_FI1 27) chain D residue 524 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE source Swiss-Prot : SWS_FT_FI1 28) chain D residue 537 type MOD_RES sequence Y description Phosphotyrosine; by Tyr-kinases => ECO:0000269|PubMed:7539106 source Swiss-Prot : SWS_FT_FI2 29) chain D residue 447 type LIPID sequence C description S-palmitoyl cysteine => ECO:0000250 source Swiss-Prot : SWS_FT_FI3

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