eF-site ID 6dfn-C PDB Code 6dfn Chain C click to enlarge Title Crystal structure of estrogen receptor alpha in complex with receptor degrader 16aa Classification NUCLEAR PROTEIN Compound Estrogen receptor Source (ESR1_HUMAN) Sequence C:  LSLTADQMVSALLDAEPPILYSEPFSEASMMGLLTNLADR ELVHMINWAKRVPGFVDLTSHDQVHLLECAWLEILMIGLV WRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATS SRFRMMNLQGEEFVCLKSIILLNSGVYTTLKSLEEKDHIH RVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRH MSNKGMEHLYSMKNVVPSYDLLLEMLDA Description Functional site 1) chain C residue 346 type sequence L description binding site for residue G9J C 601 source : AC7 2) chain C residue 347 type sequence T description binding site for residue G9J C 601 source : AC7 3) chain C residue 350 type sequence A description binding site for residue G9J C 601 source : AC7 4) chain C residue 353 type sequence E description binding site for residue G9J C 601 source : AC7 5) chain C residue 387 type sequence L description binding site for residue G9J C 601 source : AC7 6) chain C residue 394 type sequence R description binding site for residue G9J C 601 source : AC7 7) chain C residue 404 type sequence F description binding site for residue G9J C 601 source : AC7 8) chain C residue 421 type sequence M description binding site for residue G9J C 601 source : AC7 9) chain C residue 521 type sequence G description binding site for residue G9J C 601 source : AC7 10) chain C residue 524 type sequence H description binding site for residue G9J C 601 source : AC7 11) chain C residue 533 type sequence V description binding site for residue G9J C 601 source : AC7 12) chain C residue 537 type MOD_RES sequence Y description Phosphotyrosine; by Tyr-kinases => ECO:0000269|PubMed:7539106 source Swiss-Prot : SWS_FT_FI1 13) chain C residue 447 type LIPID sequence C description S-palmitoyl cysteine => ECO:0000250 source Swiss-Prot : SWS_FT_FI2

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