eF-site ID 6dfn-ABCD PDB Code 6dfn Chain A, B, C, D click to enlarge Title Crystal structure of estrogen receptor alpha in complex with receptor degrader 16aa Classification NUCLEAR PROTEIN Compound Estrogen receptor Source (ESR1_HUMAN) Sequence A:  LALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGL LTNLADRELVHMINWAKRVPGFVDLTSHDQVHLLECAWLE ILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIF DMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFTLKS LEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLL LILSHIRHMSNKGMEHLYSMVVPSYDLLLEMLDA B:  LALSLTADQMVSALLDAEPPILYSEFSEASMMGLLTNLAD RELVHMINWAKRVPGFVDLTSHDQVHLLECAWLEILMIGL VWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLAT SSRFRMMNLQGEEFVCLKSIILLNSGLEEKDHIHRVLDKI TDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGM EHLYSMKSYDLLLEMLDA C:  LSLTADQMVSALLDAEPPILYSEPFSEASMMGLLTNLADR ELVHMINWAKRVPGFVDLTSHDQVHLLECAWLEILMIGLV WRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATS SRFRMMNLQGEEFVCLKSIILLNSGVYTTLKSLEEKDHIH RVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRH MSNKGMEHLYSMKNVVPSYDLLLEMLDA D:  LALSLTADQMVSALLDAEPPILYSEYSMMGLLTNLADREL VHMINWAKRVPGFVDLTSHDQVHLLECAWLEILMIGLVWR SMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSR FRMMNLQGEEFVCLKSIILLNSGVYTKSLEEKDHIHRVLD KITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNK GMEHLYSMVPSYDLLLEMLDA Description Functional site 1) chain A residue 346 type sequence L description binding site for residue G9J A 601 source : AC1 2) chain A residue 347 type sequence T description binding site for residue G9J A 601 source : AC1 3) chain A residue 350 type sequence A description binding site for residue G9J A 601 source : AC1 4) chain A residue 353 type sequence E description binding site for residue G9J A 601 source : AC1 5) chain A residue 387 type sequence L description binding site for residue G9J A 601 source : AC1 6) chain A residue 394 type sequence R description binding site for residue G9J A 601 source : AC1 7) chain A residue 421 type sequence M description binding site for residue G9J A 601 source : AC1 8) chain A residue 424 type sequence I description binding site for residue G9J A 601 source : AC1 9) chain A residue 533 type sequence V description binding site for residue G9J A 601 source : AC1 10) chain A residue 501 type sequence H description binding site for residue NI A 602 source : AC2 11) chain B residue 497 type sequence L description binding site for residue NI A 602 source : AC2 12) chain B residue 501 type sequence H description binding site for residue NI A 602 source : AC2 13) chain B residue 346 type sequence L description binding site for residue G91 B 601 source : AC3 14) chain B residue 347 type sequence T description binding site for residue G91 B 601 source : AC3 15) chain B residue 349 type sequence L description binding site for residue G91 B 601 source : AC3 16) chain B residue 350 type sequence A description binding site for residue G91 B 601 source : AC3 17) chain B residue 351 type sequence D description binding site for residue G91 B 601 source : AC3 18) chain B residue 353 type sequence E description binding site for residue G91 B 601 source : AC3 19) chain B residue 383 type sequence W description binding site for residue G91 B 601 source : AC3 20) chain B residue 384 type sequence L description binding site for residue G91 B 601 source : AC3 21) chain B residue 388 type sequence M description binding site for residue G91 B 601 source : AC3 22) chain B residue 394 type sequence R description binding site for residue G91 B 601 source : AC3 23) chain B residue 421 type sequence M description binding site for residue G91 B 601 source : AC3 24) chain B residue 424 type sequence I description binding site for residue G91 B 601 source : AC3 25) chain B residue 521 type sequence G description binding site for residue G91 B 601 source : AC3 26) chain B residue 524 type sequence H description binding site for residue G91 B 601 source : AC3 27) chain B residue 525 type sequence L description binding site for residue G91 B 601 source : AC3 28) chain B residue 346 type sequence L description binding site for residue G9J B 602 source : AC4 29) chain B residue 347 type sequence T description binding site for residue G9J B 602 source : AC4 30) chain B residue 350 type sequence A description binding site for residue G9J B 602 source : AC4 31) chain B residue 353 type sequence E description binding site for residue G9J B 602 source : AC4 32) chain B residue 387 type sequence L description binding site for residue G9J B 602 source : AC4 33) chain B residue 394 type sequence R description binding site for residue G9J B 602 source : AC4 34) chain B residue 404 type sequence F description binding site for residue G9J B 602 source : AC4 35) chain B residue 421 type sequence M description binding site for residue G9J B 602 source : AC4 36) chain B residue 424 type sequence I description binding site for residue G9J B 602 source : AC4 37) chain B residue 322 type sequence A description binding site for residue GOL B 603 source : AC5 38) chain B residue 325 type sequence P description binding site for residue GOL B 603 source : AC5 39) chain B residue 356 type sequence H description binding site for residue GOL B 603 source : AC5 40) chain B residue 363 type sequence R description binding site for residue GOL B 603 source : AC5 41) chain A residue 512 type sequence S description binding site for residue GOL B 604 source : AC6 42) chain B residue 385 type sequence E description binding site for residue GOL B 604 source : AC6 43) chain B residue 452 type sequence I description binding site for residue GOL B 604 source : AC6 44) chain B residue 455 type sequence N description binding site for residue GOL B 604 source : AC6 45) chain B residue 456 type sequence S description binding site for residue GOL B 604 source : AC6 46) chain B residue 511 type sequence L description binding site for residue GOL B 604 source : AC6 47) chain B residue 514 type sequence I description binding site for residue GOL B 604 source : AC6 48) chain B residue 515 type sequence R description binding site for residue GOL B 604 source : AC6 49) chain C residue 346 type sequence L description binding site for residue G9J C 601 source : AC7 50) chain C residue 347 type sequence T description binding site for residue G9J C 601 source : AC7 51) chain C residue 350 type sequence A description binding site for residue G9J C 601 source : AC7 52) chain C residue 353 type sequence E description binding site for residue G9J C 601 source : AC7 53) chain C residue 387 type sequence L description binding site for residue G9J C 601 source : AC7 54) chain C residue 394 type sequence R description binding site for residue G9J C 601 source : AC7 55) chain C residue 404 type sequence F description binding site for residue G9J C 601 source : AC7 56) chain C residue 421 type sequence M description binding site for residue G9J C 601 source : AC7 57) chain C residue 521 type sequence G description binding site for residue G9J C 601 source : AC7 58) chain C residue 524 type sequence H description binding site for residue G9J C 601 source : AC7 59) chain C residue 533 type sequence V description binding site for residue G9J C 601 source : AC7 60) chain D residue 346 type sequence L description binding site for residue G9J D 601 source : AC8 61) chain D residue 347 type sequence T description binding site for residue G9J D 601 source : AC8 62) chain D residue 353 type sequence E description binding site for residue G9J D 601 source : AC8 63) chain D residue 387 type sequence L description binding site for residue G9J D 601 source : AC8 64) chain D residue 394 type sequence R description binding site for residue G9J D 601 source : AC8 65) chain D residue 421 type sequence M description binding site for residue G9J D 601 source : AC8 66) chain D residue 521 type sequence G description binding site for residue G9J D 601 source : AC8 67) chain D residue 524 type sequence H description binding site for residue G9J D 601 source : AC8 68) chain D residue 346 type sequence L description binding site for residue G91 D 602 source : AC9 69) chain D residue 347 type sequence T description binding site for residue G91 D 602 source : AC9 70) chain D residue 349 type sequence L description binding site for residue G91 D 602 source : AC9 71) chain D residue 350 type sequence A description binding site for residue G91 D 602 source : AC9 72) chain D residue 351 type sequence D description binding site for residue G91 D 602 source : AC9 73) chain D residue 353 type sequence E description binding site for residue G91 D 602 source : AC9 74) chain D residue 391 type sequence L description binding site for residue G91 D 602 source : AC9 75) chain D residue 394 type sequence R description binding site for residue G91 D 602 source : AC9 76) chain D residue 424 type sequence I description binding site for residue G91 D 602 source : AC9 77) chain D residue 428 type sequence L description binding site for residue G91 D 602 source : AC9 78) chain D residue 524 type sequence H description binding site for residue G91 D 602 source : AC9 79) chain D residue 525 type sequence L description binding site for residue G91 D 602 source : AC9 80) chain D residue 534 type sequence V description binding site for residue G91 D 602 source : AC9 81) chain D residue 322 type sequence A description binding site for residue GOL D 603 source : AD1 82) chain D residue 356 type sequence H description binding site for residue GOL D 603 source : AD1 83) chain D residue 363 type sequence R description binding site for residue GOL D 603 source : AD1 84) chain A residue 353 type BINDING sequence E description BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE source Swiss-Prot : SWS_FT_FI1 85) chain D residue 353 type BINDING sequence E description BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE source Swiss-Prot : SWS_FT_FI1 86) chain D residue 394 type BINDING sequence R description BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE source Swiss-Prot : SWS_FT_FI1 87) chain D residue 524 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE source Swiss-Prot : SWS_FT_FI1 88) chain A residue 394 type BINDING sequence R description BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE source Swiss-Prot : SWS_FT_FI1 89) chain A residue 524 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE source Swiss-Prot : SWS_FT_FI1 90) chain B residue 353 type BINDING sequence E description BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE source Swiss-Prot : SWS_FT_FI1 91) chain B residue 394 type BINDING sequence R description BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE source Swiss-Prot : SWS_FT_FI1 92) chain B residue 524 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE source Swiss-Prot : SWS_FT_FI1 93) chain C residue 353 type BINDING sequence E description BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE source Swiss-Prot : SWS_FT_FI1 94) chain C residue 394 type BINDING sequence R description BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE source Swiss-Prot : SWS_FT_FI1 95) chain C residue 524 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE source Swiss-Prot : SWS_FT_FI1 96) chain A residue 537 type MOD_RES sequence Y description Phosphotyrosine; by Tyr-kinases => ECO:0000269|PubMed:7539106 source Swiss-Prot : SWS_FT_FI2 97) chain B residue 537 type MOD_RES sequence Y description Phosphotyrosine; by Tyr-kinases => ECO:0000269|PubMed:7539106 source Swiss-Prot : SWS_FT_FI2 98) chain C residue 537 type MOD_RES sequence Y description Phosphotyrosine; by Tyr-kinases => ECO:0000269|PubMed:7539106 source Swiss-Prot : SWS_FT_FI2 99) chain D residue 537 type MOD_RES sequence Y description Phosphotyrosine; by Tyr-kinases => ECO:0000269|PubMed:7539106 source Swiss-Prot : SWS_FT_FI2 100) chain A residue 447 type LIPID sequence C description S-palmitoyl cysteine => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 101) chain B residue 447 type LIPID sequence C description S-palmitoyl cysteine => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 102) chain C residue 447 type LIPID sequence C description S-palmitoyl cysteine => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 103) chain D residue 447 type LIPID sequence C description S-palmitoyl cysteine => ECO:0000250 source Swiss-Prot : SWS_FT_FI3

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