eF-site ID 6dfn-ABCD
PDB Code 6dfn
Chain A, B, C, D

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Title Crystal structure of estrogen receptor alpha in complex with receptor degrader 16aa
Classification NUCLEAR PROTEIN
Compound Estrogen receptor
Source (ESR1_HUMAN)
Sequence A:  LALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGL
LTNLADRELVHMINWAKRVPGFVDLTSHDQVHLLECAWLE
ILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIF
DMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFTLKS
LEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLL
LILSHIRHMSNKGMEHLYSMVVPSYDLLLEMLDA
B:  LALSLTADQMVSALLDAEPPILYSEFSEASMMGLLTNLAD
RELVHMINWAKRVPGFVDLTSHDQVHLLECAWLEILMIGL
VWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLAT
SSRFRMMNLQGEEFVCLKSIILLNSGLEEKDHIHRVLDKI
TDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGM
EHLYSMKSYDLLLEMLDA
C:  LSLTADQMVSALLDAEPPILYSEPFSEASMMGLLTNLADR
ELVHMINWAKRVPGFVDLTSHDQVHLLECAWLEILMIGLV
WRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATS
SRFRMMNLQGEEFVCLKSIILLNSGVYTTLKSLEEKDHIH
RVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRH
MSNKGMEHLYSMKNVVPSYDLLLEMLDA
D:  LALSLTADQMVSALLDAEPPILYSEYSMMGLLTNLADREL
VHMINWAKRVPGFVDLTSHDQVHLLECAWLEILMIGLVWR
SMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSR
FRMMNLQGEEFVCLKSIILLNSGVYTKSLEEKDHIHRVLD
KITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNK
GMEHLYSMVPSYDLLLEMLDA
Description


Functional site

1) chain A
residue 346
type
sequence L
description binding site for residue G9J A 601
source : AC1

2) chain A
residue 347
type
sequence T
description binding site for residue G9J A 601
source : AC1

3) chain A
residue 350
type
sequence A
description binding site for residue G9J A 601
source : AC1

4) chain A
residue 353
type
sequence E
description binding site for residue G9J A 601
source : AC1

5) chain A
residue 387
type
sequence L
description binding site for residue G9J A 601
source : AC1

6) chain A
residue 394
type
sequence R
description binding site for residue G9J A 601
source : AC1

7) chain A
residue 421
type
sequence M
description binding site for residue G9J A 601
source : AC1

8) chain A
residue 424
type
sequence I
description binding site for residue G9J A 601
source : AC1

9) chain A
residue 533
type
sequence V
description binding site for residue G9J A 601
source : AC1

10) chain A
residue 501
type
sequence H
description binding site for residue NI A 602
source : AC2

11) chain B
residue 497
type
sequence L
description binding site for residue NI A 602
source : AC2

12) chain B
residue 501
type
sequence H
description binding site for residue NI A 602
source : AC2

13) chain B
residue 346
type
sequence L
description binding site for residue G91 B 601
source : AC3

14) chain B
residue 347
type
sequence T
description binding site for residue G91 B 601
source : AC3

15) chain B
residue 349
type
sequence L
description binding site for residue G91 B 601
source : AC3

16) chain B
residue 350
type
sequence A
description binding site for residue G91 B 601
source : AC3

17) chain B
residue 351
type
sequence D
description binding site for residue G91 B 601
source : AC3

18) chain B
residue 353
type
sequence E
description binding site for residue G91 B 601
source : AC3

19) chain B
residue 383
type
sequence W
description binding site for residue G91 B 601
source : AC3

20) chain B
residue 384
type
sequence L
description binding site for residue G91 B 601
source : AC3

21) chain B
residue 388
type
sequence M
description binding site for residue G91 B 601
source : AC3

22) chain B
residue 394
type
sequence R
description binding site for residue G91 B 601
source : AC3

23) chain B
residue 421
type
sequence M
description binding site for residue G91 B 601
source : AC3

24) chain B
residue 424
type
sequence I
description binding site for residue G91 B 601
source : AC3

25) chain B
residue 521
type
sequence G
description binding site for residue G91 B 601
source : AC3

26) chain B
residue 524
type
sequence H
description binding site for residue G91 B 601
source : AC3

27) chain B
residue 525
type
sequence L
description binding site for residue G91 B 601
source : AC3

28) chain B
residue 346
type
sequence L
description binding site for residue G9J B 602
source : AC4

29) chain B
residue 347
type
sequence T
description binding site for residue G9J B 602
source : AC4

30) chain B
residue 350
type
sequence A
description binding site for residue G9J B 602
source : AC4

31) chain B
residue 353
type
sequence E
description binding site for residue G9J B 602
source : AC4

32) chain B
residue 387
type
sequence L
description binding site for residue G9J B 602
source : AC4

33) chain B
residue 394
type
sequence R
description binding site for residue G9J B 602
source : AC4

34) chain B
residue 404
type
sequence F
description binding site for residue G9J B 602
source : AC4

35) chain B
residue 421
type
sequence M
description binding site for residue G9J B 602
source : AC4

36) chain B
residue 424
type
sequence I
description binding site for residue G9J B 602
source : AC4

37) chain B
residue 322
type
sequence A
description binding site for residue GOL B 603
source : AC5

38) chain B
residue 325
type
sequence P
description binding site for residue GOL B 603
source : AC5

39) chain B
residue 356
type
sequence H
description binding site for residue GOL B 603
source : AC5

40) chain B
residue 363
type
sequence R
description binding site for residue GOL B 603
source : AC5

41) chain A
residue 512
type
sequence S
description binding site for residue GOL B 604
source : AC6

42) chain B
residue 385
type
sequence E
description binding site for residue GOL B 604
source : AC6

43) chain B
residue 452
type
sequence I
description binding site for residue GOL B 604
source : AC6

44) chain B
residue 455
type
sequence N
description binding site for residue GOL B 604
source : AC6

45) chain B
residue 456
type
sequence S
description binding site for residue GOL B 604
source : AC6

46) chain B
residue 511
type
sequence L
description binding site for residue GOL B 604
source : AC6

47) chain B
residue 514
type
sequence I
description binding site for residue GOL B 604
source : AC6

48) chain B
residue 515
type
sequence R
description binding site for residue GOL B 604
source : AC6

49) chain C
residue 346
type
sequence L
description binding site for residue G9J C 601
source : AC7

50) chain C
residue 347
type
sequence T
description binding site for residue G9J C 601
source : AC7

51) chain C
residue 350
type
sequence A
description binding site for residue G9J C 601
source : AC7

52) chain C
residue 353
type
sequence E
description binding site for residue G9J C 601
source : AC7

53) chain C
residue 387
type
sequence L
description binding site for residue G9J C 601
source : AC7

54) chain C
residue 394
type
sequence R
description binding site for residue G9J C 601
source : AC7

55) chain C
residue 404
type
sequence F
description binding site for residue G9J C 601
source : AC7

56) chain C
residue 421
type
sequence M
description binding site for residue G9J C 601
source : AC7

57) chain C
residue 521
type
sequence G
description binding site for residue G9J C 601
source : AC7

58) chain C
residue 524
type
sequence H
description binding site for residue G9J C 601
source : AC7

59) chain C
residue 533
type
sequence V
description binding site for residue G9J C 601
source : AC7

60) chain D
residue 346
type
sequence L
description binding site for residue G9J D 601
source : AC8

61) chain D
residue 347
type
sequence T
description binding site for residue G9J D 601
source : AC8

62) chain D
residue 353
type
sequence E
description binding site for residue G9J D 601
source : AC8

63) chain D
residue 387
type
sequence L
description binding site for residue G9J D 601
source : AC8

64) chain D
residue 394
type
sequence R
description binding site for residue G9J D 601
source : AC8

65) chain D
residue 421
type
sequence M
description binding site for residue G9J D 601
source : AC8

66) chain D
residue 521
type
sequence G
description binding site for residue G9J D 601
source : AC8

67) chain D
residue 524
type
sequence H
description binding site for residue G9J D 601
source : AC8

68) chain D
residue 346
type
sequence L
description binding site for residue G91 D 602
source : AC9

69) chain D
residue 347
type
sequence T
description binding site for residue G91 D 602
source : AC9

70) chain D
residue 349
type
sequence L
description binding site for residue G91 D 602
source : AC9

71) chain D
residue 350
type
sequence A
description binding site for residue G91 D 602
source : AC9

72) chain D
residue 351
type
sequence D
description binding site for residue G91 D 602
source : AC9

73) chain D
residue 353
type
sequence E
description binding site for residue G91 D 602
source : AC9

74) chain D
residue 391
type
sequence L
description binding site for residue G91 D 602
source : AC9

75) chain D
residue 394
type
sequence R
description binding site for residue G91 D 602
source : AC9

76) chain D
residue 424
type
sequence I
description binding site for residue G91 D 602
source : AC9

77) chain D
residue 428
type
sequence L
description binding site for residue G91 D 602
source : AC9

78) chain D
residue 524
type
sequence H
description binding site for residue G91 D 602
source : AC9

79) chain D
residue 525
type
sequence L
description binding site for residue G91 D 602
source : AC9

80) chain D
residue 534
type
sequence V
description binding site for residue G91 D 602
source : AC9

81) chain D
residue 322
type
sequence A
description binding site for residue GOL D 603
source : AD1

82) chain D
residue 356
type
sequence H
description binding site for residue GOL D 603
source : AD1

83) chain D
residue 363
type
sequence R
description binding site for residue GOL D 603
source : AD1

84) chain A
residue 353
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE
source Swiss-Prot : SWS_FT_FI1

85) chain D
residue 353
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE
source Swiss-Prot : SWS_FT_FI1

86) chain D
residue 394
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE
source Swiss-Prot : SWS_FT_FI1

87) chain D
residue 524
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE
source Swiss-Prot : SWS_FT_FI1

88) chain A
residue 394
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE
source Swiss-Prot : SWS_FT_FI1

89) chain A
residue 524
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE
source Swiss-Prot : SWS_FT_FI1

90) chain B
residue 353
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE
source Swiss-Prot : SWS_FT_FI1

91) chain B
residue 394
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE
source Swiss-Prot : SWS_FT_FI1

92) chain B
residue 524
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE
source Swiss-Prot : SWS_FT_FI1

93) chain C
residue 353
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE
source Swiss-Prot : SWS_FT_FI1

94) chain C
residue 394
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE
source Swiss-Prot : SWS_FT_FI1

95) chain C
residue 524
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE
source Swiss-Prot : SWS_FT_FI1

96) chain A
residue 537
type MOD_RES
sequence Y
description Phosphotyrosine; by Tyr-kinases => ECO:0000269|PubMed:7539106
source Swiss-Prot : SWS_FT_FI2

97) chain B
residue 537
type MOD_RES
sequence Y
description Phosphotyrosine; by Tyr-kinases => ECO:0000269|PubMed:7539106
source Swiss-Prot : SWS_FT_FI2

98) chain C
residue 537
type MOD_RES
sequence Y
description Phosphotyrosine; by Tyr-kinases => ECO:0000269|PubMed:7539106
source Swiss-Prot : SWS_FT_FI2

99) chain D
residue 537
type MOD_RES
sequence Y
description Phosphotyrosine; by Tyr-kinases => ECO:0000269|PubMed:7539106
source Swiss-Prot : SWS_FT_FI2

100) chain A
residue 447
type LIPID
sequence C
description S-palmitoyl cysteine => ECO:0000250
source Swiss-Prot : SWS_FT_FI3

101) chain B
residue 447
type LIPID
sequence C
description S-palmitoyl cysteine => ECO:0000250
source Swiss-Prot : SWS_FT_FI3

102) chain C
residue 447
type LIPID
sequence C
description S-palmitoyl cysteine => ECO:0000250
source Swiss-Prot : SWS_FT_FI3

103) chain D
residue 447
type LIPID
sequence C
description S-palmitoyl cysteine => ECO:0000250
source Swiss-Prot : SWS_FT_FI3


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