eF-site ID 6dfn-A PDB Code 6dfn Chain A click to enlarge Title Crystal structure of estrogen receptor alpha in complex with receptor degrader 16aa Classification NUCLEAR PROTEIN Compound Estrogen receptor Source (ESR1_HUMAN) Sequence A:  LALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGL LTNLADRELVHMINWAKRVPGFVDLTSHDQVHLLECAWLE ILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIF DMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFTLKS LEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLL LILSHIRHMSNKGMEHLYSMVVPSYDLLLEMLDA Description Functional site 1) chain A residue 346 type sequence L description binding site for residue G9J A 601 source : AC1 2) chain A residue 347 type sequence T description binding site for residue G9J A 601 source : AC1 3) chain A residue 350 type sequence A description binding site for residue G9J A 601 source : AC1 4) chain A residue 353 type sequence E description binding site for residue G9J A 601 source : AC1 5) chain A residue 387 type sequence L description binding site for residue G9J A 601 source : AC1 6) chain A residue 394 type sequence R description binding site for residue G9J A 601 source : AC1 7) chain A residue 421 type sequence M description binding site for residue G9J A 601 source : AC1 8) chain A residue 424 type sequence I description binding site for residue G9J A 601 source : AC1 9) chain A residue 533 type sequence V description binding site for residue G9J A 601 source : AC1 10) chain A residue 501 type sequence H description binding site for residue NI A 602 source : AC2 11) chain A residue 512 type sequence S description binding site for residue GOL B 604 source : AC6 12) chain A residue 537 type MOD_RES sequence Y description Phosphotyrosine; by Tyr-kinases => ECO:0000269|PubMed:7539106 source Swiss-Prot : SWS_FT_FI1 13) chain A residue 447 type LIPID sequence C description S-palmitoyl cysteine => ECO:0000250 source Swiss-Prot : SWS_FT_FI2

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