eF-site ID 6ddi-ABC PDB Code 6ddi Chain A, B, C click to enlarge Title Crystal Structure of the human BRD2 BD1 bromodomain in complex with a Tetrahydroquinoline analogue Classification Transcription/Inhibitor Compound Bromodomain-containing protein 2 Source (BRD2_HUMAN) Sequence A:  GRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPD YHKIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFTNC YIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQEL B:  TNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHK IIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIY NKPTDDIVLMAQTLEKIFLQKVASMPQ C:  TNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHK IIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIY NKPTDDIVLMAQTLEKIFLQKVASMPQ Description Functional site 1) chain A residue 97 type sequence W description binding site for residue G7V A 301 source : AC1 2) chain A residue 98 type sequence P description binding site for residue G7V A 301 source : AC1 3) chain A residue 99 type sequence F description binding site for residue G7V A 301 source : AC1 4) chain A residue 107 type sequence K description binding site for residue G7V A 301 source : AC1 5) chain A residue 108 type sequence L description binding site for residue G7V A 301 source : AC1 6) chain A residue 110 type sequence L description binding site for residue G7V A 301 source : AC1 7) chain A residue 152 type sequence C description binding site for residue G7V A 301 source : AC1 8) chain A residue 156 type sequence N description binding site for residue G7V A 301 source : AC1 9) chain B residue 94 type sequence Q description binding site for residue G7V A 301 source : AC1 10) chain A residue 100 type sequence R description binding site for residue SO4 A 302 source : AC2 11) chain A residue 160 type sequence D description binding site for residue EDO A 303 source : AC3 12) chain A residue 161 type sequence D description binding site for residue EDO A 303 source : AC3 13) chain A residue 162 type sequence I description binding site for residue EDO A 303 source : AC3 14) chain A residue 94 type sequence Q description binding site for residue EDO A 304 source : AC4 15) chain A residue 97 type sequence W description binding site for residue EDO A 304 source : AC4 16) chain B residue 94 type sequence Q description binding site for residue EDO A 304 source : AC4 17) chain B residue 97 type sequence W description binding site for residue EDO A 304 source : AC4 18) chain B residue 165 type sequence M description binding site for residue EDO A 304 source : AC4 19) chain A residue 94 type sequence Q description binding site for residue G7V B 301 source : AC5 20) chain B residue 97 type sequence W description binding site for residue G7V B 301 source : AC5 21) chain B residue 98 type sequence P description binding site for residue G7V B 301 source : AC5 22) chain B residue 99 type sequence F description binding site for residue G7V B 301 source : AC5 23) chain B residue 110 type sequence L description binding site for residue G7V B 301 source : AC5 24) chain B residue 152 type sequence C description binding site for residue G7V B 301 source : AC5 25) chain B residue 156 type sequence N description binding site for residue G7V B 301 source : AC5 26) chain B residue 97 type sequence W description binding site for residue 03S B 302 source : AC6 27) chain B residue 100 type sequence R description binding site for residue 03S B 302 source : AC6 28) chain C residue 132 type sequence N description binding site for residue 03S B 302 source : AC6 29) chain C residue 134 type sequence Y description binding site for residue 03S B 302 source : AC6 30) chain B residue 160 type sequence D description binding site for residue EDO B 303 source : AC7 31) chain B residue 161 type sequence D description binding site for residue EDO B 303 source : AC7 32) chain B residue 162 type sequence I description binding site for residue EDO B 303 source : AC7 33) chain A residue 80 type sequence Q description binding site for residue G7V C 301 source : AC8 34) chain A residue 84 type sequence K description binding site for residue G7V C 301 source : AC8 35) chain A residue 181 type sequence P description binding site for residue G7V C 301 source : AC8 36) chain C residue 97 type sequence W description binding site for residue G7V C 301 source : AC8 37) chain C residue 98 type sequence P description binding site for residue G7V C 301 source : AC8 38) chain C residue 101 type sequence Q description binding site for residue G7V C 301 source : AC8 39) chain C residue 110 type sequence L description binding site for residue G7V C 301 source : AC8 40) chain C residue 156 type sequence N description binding site for residue G7V C 301 source : AC8 41) chain A residue 84 type MOD_RES sequence K description Phosphoserine => ECO:0007744|PubMed:19690332 source Swiss-Prot : SWS_FT_FI2 42) chain B residue 84 type MOD_RES sequence K description Phosphoserine => ECO:0007744|PubMed:19690332 source Swiss-Prot : SWS_FT_FI2 43) chain C residue 84 type MOD_RES sequence K description Phosphoserine => ECO:0007744|PubMed:19690332 source Swiss-Prot : SWS_FT_FI2 44) chain A residue 159 type BINDING sequence T description BINDING => ECO:0000269|PubMed:37731000, ECO:0007744|PDB:8SB6 source Swiss-Prot : SWS_FT_FI1 45) chain B residue 159 type BINDING sequence T description BINDING => ECO:0000269|PubMed:37731000, ECO:0007744|PDB:8SB6 source Swiss-Prot : SWS_FT_FI1 46) chain C residue 159 type BINDING sequence T description BINDING => ECO:0000269|PubMed:37731000, ECO:0007744|PDB:8SB6 source Swiss-Prot : SWS_FT_FI1 47) chain A residue 96-155 type prosite sequence AWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYY WAASECMQDFNTMFTNCYIY description BROMODOMAIN_1 Bromodomain signature. AwpFrqpvDavklglpDYHkiIkqpMdmgtIkrrlenny..Ywaasecmqdfnt.MftNCyiY source prosite : PS00633

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