eF-site ID 6dc8-HLP PDB Code 6dc8 Chain H, L, P click to enlarge Title Fab/epitope complex of mouse monoclonal antibody 8B2 targeting a non-phosphorylated tau epitope. Classification IMMUNE SYSTEM Compound IgG light chain Source ORGANISM_COMMON: mouse; ORGANISM_SCIENTIFIC: Mus musculus; Sequence H:  EVQLQQSGPELVKPGASVKMSCKASGYTFTSYVIHWVKQK PGQGLEWIGYIYPYNDGTIYNEKFKGKATLTSDTSSSTVY MELISLTAEDSAVYWCVRERDNYGVYWGQGTTLTVSSAKT TPPSVYPLAPGTGDTGSSMVTLGCLVKGYFPEPVTVTWNS GSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQTITCN VAHPASSTKVDKKIVPE L:  DVLLTQTPLSLPVSLGDQASISCRSSQSIVHSNGNTYLEW YLQKPGQSPELLIYKVSNRFYGVPDRFSGSGSGTDFTLKI SRVEAEDLGVYYCFQDSHIPYTFGGGTRLEIKRADAAPTV SIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSER QNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCE ATHKTSTSPIVKSFNRNE P:  SPRHLX Description (1)  Mouse monoclonal antibody C5.2 Fab light chain, Mouse monoclonal antibody C5.2 Fab heavy chain, Microtubule-associated protein tau Functional site 1) chain L residue 37 type sequence L description binding site for residue GOL L 301 source : AC1 2) chain L residue 39 type sequence K description binding site for residue GOL L 301 source : AC1 3) chain L residue 45 type sequence E description binding site for residue GOL L 301 source : AC1 4) chain L residue 81 type sequence E description binding site for residue GOL L 301 source : AC1 5) chain L residue 82 type sequence D description binding site for residue GOL L 301 source : AC1 6) chain H residue 96 type sequence R description binding site for residue GOL H 301 source : AC2 7) chain H residue 97 type sequence D description binding site for residue GOL H 301 source : AC2 8) chain H residue 98 type sequence N description binding site for residue GOL H 301 source : AC2 9) chain L residue 49 type sequence Y description binding site for residue GOL H 301 source : AC2 10) chain L residue 55 type sequence F description binding site for residue GOL H 301 source : AC2 11) chain L residue 151 type sequence D description binding site for residue GOL H 301 source : AC2 12) chain H residue 119 type sequence P description binding site for residue GOL H 302 source : AC3 13) chain H residue 121 type sequence V description binding site for residue GOL H 302 source : AC3 14) chain H residue 204 type sequence T description binding site for residue GOL H 302 source : AC3 15) chain H residue 208 type sequence K description binding site for residue GOL H 302 source : AC3 16) chain L residue 32 type sequence Y description binding site for residue PO4 P 501 source : AC4 17) chain L residue 50 type sequence K description binding site for residue PO4 P 501 source : AC4 18) chain L residue 189 type sequence H description binding site for residue PO4 P 501 source : AC4 19) chain P residue 404 type sequence S description binding site for residue PO4 P 501 source : AC4 20) chain P residue 407 type sequence H description binding site for residue PO4 P 501 source : AC4 21) chain L residue 192-198 type prosite sequence YTCEATH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH source prosite : PS00290 22) chain P residue 404 type MOD_RES sequence S description Phosphoserine; by CK1 and PDPK1 => ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:21327254, ECO:0000269|PubMed:9614189, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI7

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