eF-site ID 6dbi-A PDB Code 6dbi Chain A click to enlarge Title Cryo-EM structure of RAG in complex with 12-RSS and 23-RSS nicked DNA intermediates Classification RECOMBINATION/DNA Compound Recombination activating gene 1 - MBP chimera Source (6DBI) Sequence A:  GGRPRQHLLSLTRRAQKHRLRDLKNQVKTFAEKEEGGDVK SVCLTLFLLALRAGNEHKQADELEAMMQGRGFGLHPAVCL AIRVNTFLSCSQYHKMYRTVKATSGRQIFQPLHTLRNAEK ELLPGFHQFEWQPALKNVSTSWDVGIIDGLSGWTVSVDDV PADTISRRFRYDVALVSALKDLEEDIMEGLRERALDDSMC TSGFTVVVKESCDGMGDVSEKHGSGPAVPEKAVRFSFTIM SISIRLEGEDDGITIFQEQKPNSELSCRPLCLMFVDESDH ETLTAILGPVVAERKAMMESRLIISVGGLLRSFRFFFRGT GYDEKMVREMEGLEASGSTYICTLCDSTRAEASQNMVLHS ITRSHDENLERYEIWRKNPFSESADELRDRVKGVSAKPFM ETQPTLDALHCDIGNATEFYKIFQDEIGEVYQKPNPSREE RRRWRSTLDKQLRKKMKLKPVMRMNGNYARRLMTREAVEA VCELVPSEERREALLKLMDLYLQMKPVWRSTCPSRDCPDQ LCQYSYNSQQFADLLSSMFKYRYDGKITNYLHKTLAHVPE IVERDGSIGAWASEGNESGNKLFRRFRKMNARQSKTFELE DILKHHWLYTSKYLQKFMEAHK Description Functional site 1) chain A residue 749 type sequence C description binding site for residue ZN A 1101 source : AC4 2) chain A residue 752 type sequence C description binding site for residue ZN A 1101 source : AC4 3) chain A residue 959 type sequence H description binding site for residue ZN A 1101 source : AC4 4) chain A residue 964 type sequence H description binding site for residue ZN A 1101 source : AC4 5) chain A residue 684 type sequence E description binding site for residue CA A 1102 source : AC5 6) chain A residue 620 type sequence D description binding site for residue CA A 1103 source : AC6 7) chain A residue 730 type sequence D description binding site for residue CA A 1103 source : AC6 8) chain A residue 408-475 type DNA_BIND sequence GGRPRQHLLSLTRRAQKHRLRDLKNQVKTFAEKEEGGDVK SVCLTLFLLALRAGNEHKQADELEAMMQ description NBD => ECO:0000255|PROSITE-ProRule:PRU00820 source Swiss-Prot : SWS_FT_FI3 9) chain A residue 620 type BINDING sequence D description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI4 10) chain A residue 730 type BINDING sequence D description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI4 11) chain A residue 984 type BINDING sequence E description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI4 12) chain A residue 915 type SITE sequence W description Essential for DNA hairpin formation, participates in base-stacking interactions near the cleavage site => ECO:0000250 source Swiss-Prot : SWS_FT_FI6

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