eF-site ID 6dbc-A PDB Code 6dbc Chain A click to enlarge Title Second bromodomain of Human BRD2 with a Tetrahydroquinoline analogue Classification Transcription/inhibitor Compound Bromodomain-containing protein 2 Source (BRD2_HUMAN) Sequence A:  GSHMQDPEQLKHCNGILKELLSKKHAAYAWPFYKPVDASA LGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRL MFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPD Description Functional site 1) chain A residue 350 type sequence L description binding site for residue EDO A 501 source : AC1 2) chain A residue 389 type sequence I description binding site for residue EDO A 502 source : AC2 3) chain A residue 390 type sequence I description binding site for residue EDO A 502 source : AC2 4) chain A residue 391 type sequence K description binding site for residue EDO A 502 source : AC2 5) chain A residue 392 type sequence H description binding site for residue EDO A 502 source : AC2 6) chain A residue 424 type sequence N description binding site for residue EDO A 502 source : AC2 7) chain A residue 427 type sequence K description binding site for residue EDO A 502 source : AC2 8) chain A residue 455 type sequence D description binding site for residue EDO A 502 source : AC2 9) chain A residue 368 type sequence Y description binding site for residue EDO A 503 source : AC3 10) chain A residue 402 type sequence K description binding site for residue EDO A 503 source : AC3 11) chain A residue 407 type sequence D description binding site for residue EDO A 503 source : AC3 12) chain A residue 413 type sequence E description binding site for residue EDO A 503 source : AC3 13) chain A residue 438 type sequence M description binding site for residue EDO A 503 source : AC3 14) chain A residue 441 type sequence K description binding site for residue EDO A 503 source : AC3 15) chain A residue 426 type sequence Y description binding site for residue EDO A 504 source : AC4 16) chain A residue 440 type sequence R description binding site for residue EDO A 504 source : AC4 17) chain A residue 443 type sequence Q description binding site for residue EDO A 504 source : AC4 18) chain A residue 443 type sequence Q description binding site for residue EDO A 504 source : AC4 19) chain A residue 444 type sequence D description binding site for residue EDO A 504 source : AC4 20) chain A residue 448 type sequence F description binding site for residue EDO A 504 source : AC4 21) chain A residue 433 type sequence H description binding site for residue EDO A 505 source : AC5 22) chain A residue 434 type sequence D description binding site for residue EDO A 505 source : AC5 23) chain A residue 361 type sequence L description binding site for residue EDO A 506 source : AC6 24) chain A residue 373 type sequence Y description binding site for residue EDO A 506 source : AC6 25) chain A residue 381 type sequence L description binding site for residue EDO A 507 source : AC7 26) chain A residue 370 type sequence W description binding site for residue G3J A 508 source : AC8 27) chain A residue 371 type sequence P description binding site for residue G3J A 508 source : AC8 28) chain A residue 383 type sequence L description binding site for residue G3J A 508 source : AC8 29) chain A residue 429 type sequence N description binding site for residue G3J A 508 source : AC8 30) chain A residue 433 type sequence H description binding site for residue G3J A 508 source : AC8 31) chain A residue 435 type sequence V description binding site for residue G3J A 508 source : AC8 32) chain A residue 369-428 type prosite sequence AWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDY RDAQEFAADVRLMFSNCYKY description BROMODOMAIN_1 Bromodomain signature. AwpFykpvDasalglhDYHdiIkhpMdlstVkrkmenrd..Yrdaqefaadvrl.MfsNCykY source prosite : PS00633

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