eF-site ID 6da1-ABC PDB Code 6da1 Chain A, B, C click to enlarge Title ETS1 in complex with synthetic SRR mimic Classification DNA BINDING PROTEIN Compound Protein C-ets-1 Source (6DA1) Sequence A:  GTFKDYVRDRADLNKDKPVIPAAALAGYTGSGPIQLWQFL LELLTDKSCQSFISWTGDGWEFKLSDPDEVARRWGKRKNK PKMNYEKLSRGLRYYYDKNIIHKTAGKRYVYRFVCDLQSL LGYTPEELHAMLDVKPD B:  KGTFKDYVRDRADLNKDKPVIPAAALAGYTGSGPIQLWQF LLELLTDKSCQSFISWTGDGWEFKLSDPDEVARRWGKRKN KPKMNYEKLSRGLRYYYDKNIIHKTAGKRYVYRFVCDLQS LLGYTPEELHAMLDVKPD C:  PXXDXXDXEDXPAALWX Description Functional site 1) chain A residue 311 type sequence R description binding site for residue SO4 A 501 source : AC1 2) chain A residue 316 type sequence K description binding site for residue SO4 A 501 source : AC1 3) chain A residue 374 type sequence R description binding site for residue SO4 A 501 source : AC1 4) chain A residue 335 type sequence I description binding site for residue SO4 B 501 source : AC2 5) chain A residue 379 type sequence K description binding site for residue SO4 B 501 source : AC2 6) chain B residue 335 type sequence I description binding site for residue SO4 B 501 source : AC2 7) chain B residue 378 type sequence R description binding site for residue SO4 B 501 source : AC2 8) chain B residue 379 type sequence K description binding site for residue SO4 B 501 source : AC2 9) chain B residue 311 type sequence R description binding site for residue SO4 B 502 source : AC3 10) chain B residue 316 type sequence K description binding site for residue SO4 B 502 source : AC3 11) chain B residue 373 type sequence R description binding site for residue SO4 B 502 source : AC3 12) chain B residue 374 type sequence R description binding site for residue SO4 B 502 source : AC3 13) chain B residue 336 type sequence Q description binding site for residues SEP C 282 and PF5 C 283 source : AC4 14) chain B residue 338 type sequence W description binding site for residues SEP C 282 and PF5 C 283 source : AC4 15) chain B residue 399 type sequence K description binding site for residues SEP C 282 and PF5 C 283 source : AC4 16) chain B residue 401 type sequence I description binding site for residues SEP C 282 and PF5 C 283 source : AC4 17) chain B residue 421 type sequence L description binding site for residues SEP C 282 and PF5 C 283 source : AC4 18) chain C residue 284 type sequence D description binding site for residues SEP C 282 and PF5 C 283 source : AC4 19) chain C residue 285 type sequence X description binding site for residues SEP C 282 and PF5 C 283 source : AC4 20) chain C residue 286 type sequence X description binding site for residues SEP C 282 and PF5 C 283 source : AC4 21) chain B residue 336 type sequence Q description binding site for Di-peptide PF5 C 283 and ASP C 284 source : AC5 22) chain B residue 338 type sequence W description binding site for Di-peptide PF5 C 283 and ASP C 284 source : AC5 23) chain B residue 401 type sequence I description binding site for Di-peptide PF5 C 283 and ASP C 284 source : AC5 24) chain B residue 421 type sequence L description binding site for Di-peptide PF5 C 283 and ASP C 284 source : AC5 25) chain C residue 282 type sequence X description binding site for Di-peptide PF5 C 283 and ASP C 284 source : AC5 26) chain C residue 285 type sequence X description binding site for Di-peptide PF5 C 283 and ASP C 284 source : AC5 27) chain C residue 286 type sequence X description binding site for Di-peptide PF5 C 283 and ASP C 284 source : AC5 28) chain A residue 381 type sequence K description binding site for Di-peptide ASP C 284 and SEP C 285 source : AC6 29) chain A residue 388 type sequence K description binding site for Di-peptide ASP C 284 and SEP C 285 source : AC6 30) chain C residue 282 type sequence X description binding site for Di-peptide ASP C 284 and SEP C 285 source : AC6 31) chain C residue 283 type sequence X description binding site for Di-peptide ASP C 284 and SEP C 285 source : AC6 32) chain C residue 286 type sequence X description binding site for Di-peptide ASP C 284 and SEP C 285 source : AC6 33) chain A residue 381 type sequence K description binding site for residues SEP C 285 and PF5 C 286 source : AC7 34) chain A residue 388 type sequence K description binding site for residues SEP C 285 and PF5 C 286 source : AC7 35) chain B residue 336 type sequence Q description binding site for residues SEP C 285 and PF5 C 286 source : AC7 36) chain B residue 395 type sequence Y description binding site for residues SEP C 285 and PF5 C 286 source : AC7 37) chain B residue 396 type sequence Y description binding site for residues SEP C 285 and PF5 C 286 source : AC7 38) chain C residue 283 type sequence X description binding site for residues SEP C 285 and PF5 C 286 source : AC7 39) chain C residue 284 type sequence D description binding site for residues SEP C 285 and PF5 C 286 source : AC7 40) chain C residue 287 type sequence D description binding site for residues SEP C 285 and PF5 C 286 source : AC7 41) chain C residue 288 type sequence X description binding site for residues SEP C 285 and PF5 C 286 source : AC7 42) chain C residue 293 type sequence A description binding site for residues SEP C 285 and PF5 C 286 source : AC7 43) chain A residue 381 type sequence K description binding site for Di-peptide PF5 C 286 and ASP C 287 source : AC8 44) chain B residue 336 type sequence Q description binding site for Di-peptide PF5 C 286 and ASP C 287 source : AC8 45) chain B residue 395 type sequence Y description binding site for Di-peptide PF5 C 286 and ASP C 287 source : AC8 46) chain B residue 396 type sequence Y description binding site for Di-peptide PF5 C 286 and ASP C 287 source : AC8 47) chain C residue 283 type sequence X description binding site for Di-peptide PF5 C 286 and ASP C 287 source : AC8 48) chain C residue 284 type sequence D description binding site for Di-peptide PF5 C 286 and ASP C 287 source : AC8 49) chain C residue 285 type sequence X description binding site for Di-peptide PF5 C 286 and ASP C 287 source : AC8 50) chain C residue 288 type sequence X description binding site for Di-peptide PF5 C 286 and ASP C 287 source : AC8 51) chain C residue 293 type sequence A description binding site for Di-peptide PF5 C 286 and ASP C 287 source : AC8 52) chain C residue 295 type sequence L description binding site for Di-peptide PF5 C 286 and ASP C 287 source : AC8 53) chain C residue 296 type sequence W description binding site for Di-peptide PF5 C 286 and ASP C 287 source : AC8 54) chain A residue 381 type sequence K description binding site for Di-peptide ASP C 287 and PF5 C 288 source : AC9 55) chain A residue 388 type sequence K description binding site for Di-peptide ASP C 287 and PF5 C 288 source : AC9 56) chain A residue 391 type sequence R description binding site for Di-peptide ASP C 287 and PF5 C 288 source : AC9 57) chain B residue 395 type sequence Y description binding site for Di-peptide ASP C 287 and PF5 C 288 source : AC9 58) chain C residue 286 type sequence X description binding site for Di-peptide ASP C 287 and PF5 C 288 source : AC9 59) chain C residue 289 type sequence E description binding site for Di-peptide ASP C 287 and PF5 C 288 source : AC9 60) chain C residue 290 type sequence D description binding site for Di-peptide ASP C 287 and PF5 C 288 source : AC9 61) chain C residue 291 type sequence X description binding site for Di-peptide ASP C 287 and PF5 C 288 source : AC9 62) chain C residue 293 type sequence A description binding site for Di-peptide ASP C 287 and PF5 C 288 source : AC9 63) chain C residue 295 type sequence L description binding site for Di-peptide ASP C 287 and PF5 C 288 source : AC9 64) chain C residue 296 type sequence W description binding site for Di-peptide ASP C 287 and PF5 C 288 source : AC9 65) chain A residue 336 type sequence Q description binding site for Di-peptide PF5 C 288 and GLU C 289 source : AD1 66) chain A residue 337 type sequence L description binding site for Di-peptide PF5 C 288 and GLU C 289 source : AD1 67) chain A residue 388 type sequence K description binding site for Di-peptide PF5 C 288 and GLU C 289 source : AD1 68) chain A residue 391 type sequence R description binding site for Di-peptide PF5 C 288 and GLU C 289 source : AD1 69) chain A residue 396 type sequence Y description binding site for Di-peptide PF5 C 288 and GLU C 289 source : AD1 70) chain B residue 395 type sequence Y description binding site for Di-peptide PF5 C 288 and GLU C 289 source : AD1 71) chain C residue 286 type sequence X description binding site for Di-peptide PF5 C 288 and GLU C 289 source : AD1 72) chain C residue 287 type sequence D description binding site for Di-peptide PF5 C 288 and GLU C 289 source : AD1 73) chain C residue 290 type sequence D description binding site for Di-peptide PF5 C 288 and GLU C 289 source : AD1 74) chain C residue 291 type sequence X description binding site for Di-peptide PF5 C 288 and GLU C 289 source : AD1 75) chain C residue 296 type sequence W description binding site for Di-peptide PF5 C 288 and GLU C 289 source : AD1 76) chain A residue 395 type sequence Y description binding site for Di-peptide ASP C 290 and PF5 C 291 source : AD2 77) chain B residue 337 type sequence L description binding site for Di-peptide ASP C 290 and PF5 C 291 source : AD2 78) chain B residue 375 type sequence W description binding site for Di-peptide ASP C 290 and PF5 C 291 source : AD2 79) chain B residue 384 type sequence M description binding site for Di-peptide ASP C 290 and PF5 C 291 source : AD2 80) chain B residue 388 type sequence K description binding site for Di-peptide ASP C 290 and PF5 C 291 source : AD2 81) chain B residue 391 type sequence R description binding site for Di-peptide ASP C 290 and PF5 C 291 source : AD2 82) chain B residue 392 type sequence G description binding site for Di-peptide ASP C 290 and PF5 C 291 source : AD2 83) chain B residue 395 type sequence Y description binding site for Di-peptide ASP C 290 and PF5 C 291 source : AD2 84) chain C residue 288 type sequence X description binding site for Di-peptide ASP C 290 and PF5 C 291 source : AD2 85) chain C residue 289 type sequence E description binding site for Di-peptide ASP C 290 and PF5 C 291 source : AD2 86) chain C residue 293 type sequence A description binding site for Di-peptide ASP C 290 and PF5 C 291 source : AD2 87) chain A residue 337-345 type prosite sequence LWQFLLELL description ETS_DOMAIN_1 Ets-domain signature 1. LWQFLLELL source prosite : PS00345 88) chain A residue 381-396 type prosite sequence KPKMNYEKLSRGLRYY description ETS_DOMAIN_2 Ets-domain signature 2. KpkMnYEkLSRGLRyY source prosite : PS00346 89) chain A residue 335-415 type DNA_BIND sequence IQLWQFLLELLTDKSCQSFISWTGDGWEFKLSDPDEVARR WGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTAGKRYVYRF V description ETS => ECO:0000255|PROSITE-ProRule:PRU00237 source Swiss-Prot : SWS_FT_FI1 90) chain B residue 335-415 type DNA_BIND sequence IQLWQFLLELLTDKSCQSFISWTGDGWEFKLSDPDEVARR WGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTAGKRYVYRF V description ETS => ECO:0000255|PROSITE-ProRule:PRU00237 source Swiss-Prot : SWS_FT_FI1 91) chain A residue 305 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P14921 source Swiss-Prot : SWS_FT_FI2 92) chain B residue 305 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P14921 source Swiss-Prot : SWS_FT_FI2

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