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eF-site ID
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6d73-D |
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PDB Code
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6d73 |
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Chain
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D |
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click to enlarge
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Title
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Cryo-EM structure of the zebrafish TRPM2 channel in the presence of Ca2+ |
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Classification
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TRANSPORT PROTEIN |
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Compound
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Transient receptor potential cation channel, subfamily M |
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Source
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(6D73) |
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Sequence
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D: |
LASWIKENIKKKEQWDKHRHVRETPTDAFGDISFGGLGQK
TGKYVRVSSDTSCENLYQLMTEQWKLRSPNLLISVTGGAK
NFYIKTHLKDKFRRGLIKVAQTTGAWILTGGTHAGVMKHV
GMAVRDYTLSSGSMEGQIVVIGVAPWGVIHNRSTLIHPEG
RFPAYYSLDEQGQGRLSCLDINHTHFLLVDDGTQGHYGVE
IELRARLEKLISKLSLGGVTIPVVCVVLDGGPGTLNTIYN
SMLNHTPCVVLEGSGRLADVIAHVASVPVSKVTMALINRL
LKRFFMQEYKNFTELQIIEWTKKIQDILRMPHLLTVFRID
EDKNYDVDVAILQALLKASRSDEHAGRHCWERQLELAVAW
NRVDIAESEIFTEESQWTSSDLHPAMFSALVGDKPEFVRL
LLENGVCVREFLEREETLCELYSHLPSCFFLRKLAKRVQE
PLPGSRKVCLSHVSEEVRHLLGSFTQPLYIASRYDTVWDP
GRDLFLWAVVQNNRELAEIGWEQCRDCIAAALAASKILRK
LAQESGEDDSEEATEMLELANHYEKQAIGVFSECHSWDAQ
RAQKLLIRISPSWGRSTCLWLALEAHDKSFIAHSGVQALL
TQIWCGELSVDNPHWKVLLCMIFFPLIYTGFLTFRRDEDI
QRQAERTEQQKNCSSRLMSFLKSPQVKFYWNIASYFGFLW
LFAVVLMIDFQTSPSWRELLLYVWLTSLVCEEIRQLYHDG
FRRKAKMYIKDLWNILDVLSIVLFIAGLICRLQASDTVFY
IGKVILCIDFIIFCLRLMAIFSISRTLGPKIIIVRRMMLD
LFFFMFLLSIWVVAYGVAKQGILIENEERLNWIIRGAVYE
PYITIFGNFPTNIDNTLFDISSCSVNASDPLKPKCPMLNA
DNTPVFPEWLTIMMLCVYLLFANILLLNLLIAIFNYTFQE
VQDNTDTIWKFQRYELIKEYHSRPALPPPFILLSHLILFI
RGVFLRHKNFRQELEQTEEEELLSWEAYMKDNYLASTRQD
ESQSVEHRIHDTAEKVGAMSELLEREQEMVXXXXXXXXXX
XXXXXXXXXXXXEEAPHMFARQLQYPDSTVRRFPVPEEKV
SWEVNFSPYQPPVYNQQDKHRNPGGRTGIRGKGALNTLGP
NHILHPIFTRWRDAEHKVLEFLAVWEDAEKRWALLGGPAQ
PDLAQVLERILGKKLKTLLKAGEEVYKGYVDDSRNTDNAW
VETSIITLHTPLMADLNHMVESSLSSHQPLQWREVSSDAC
RCSYQREALRQIAHHH
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Description
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(1) |
Transient receptor potential cation channel subfamily M member 8
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Functional site
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1)
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chain |
D |
| residue |
857 |
| type |
|
| sequence |
E
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| description |
binding site for residue CA D 1601
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| source |
: AC4
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2)
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chain |
D |
| residue |
860 |
| type |
|
| sequence |
Q
|
| description |
binding site for residue CA D 1601
|
| source |
: AC4
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|
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3)
|
chain |
D |
| residue |
883 |
| type |
|
| sequence |
N
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| description |
binding site for residue CA D 1601
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| source |
: AC4
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|
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4)
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chain |
D |
| residue |
886 |
| type |
|
| sequence |
D
|
| description |
binding site for residue CA D 1601
|
| source |
: AC4
|
|
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5)
|
chain |
D |
| residue |
925 |
| type |
|
| sequence |
R
|
| description |
binding site for residue CA D 1601
|
| source |
: AC4
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