eF-site ID 6d73-ABCD PDB Code 6d73 Chain A, B, C, D Title Cryo-EM structure of the zebrafish TRPM2 channel in the presence of Ca2+ Classification TRANSPORT PROTEIN Compound Transient receptor potential cation channel, subfamily M Source (6D73) Sequence A:  LASWIKENIKKKEWDKHRHVRETPTDAFGDISFGGLGQKT GKYVRVSSDTSCENLYQLMTEQWKLRSPNLLISVTGGAKN FYIKTHLKDKFRRGLIKVAQTTGAWILTGGTHAGVMKHVG MAVRDYTLSSGSMEGQIVVIGVAPWGVIHNRSTLIHPEGR FPAYYSLDEQGQGRLSCLDINHTHFLLVDDGTQGHYGVEI ELRARLEKLISKLSLGNRESGVTIPVVCVVLDGGPGTLNT IYNSMLNHTPCVVLEGSGRLADVIAHVASVPVSKVTMALI NRLLKRFFMQEYKNFTELQIIEWTKKIQDILRMPHLLTVF RIDEDKNYDVDVAILQALLKASRSDEHAGRHCWERQLELA VAWNRVDIAESEIFTEESQWTSSDLHPAMFSALVGDKPEF VRLLLENGVCVREFLEREETLCELYSHLPSCFFLRKLAKR VQCLSHVSEEVRHLLGSFTQPLYIASRYKDTVWDPGRDLF LWAVVQNNRELAEIGWEQCRDCIAAALAASKILRKLAQES GEDDSEEATEMLELANHYEKQAIGVFSECHSWDAQRAQKL LIRISPSWGRSTCLWLALEAHDKSFIAHSGVQALLTQIWC GELSVDNPHWKVLLCMIFFPLIYTGFLTFRRDEDIQRQAE RTEQCSSRLMSFLKSPQVKFYWNIASYFGFLWLFAVVLMI DFQTSPSWRELLLYVWLTSLVCEEIRQLYHDFDGSGFRRK AKMYIKDLWNILDVLSIVLFIAGLICRLQASDTVFYIGKV ILCIDFIIFCLRLMAIFSISRTLGPKIIIVRRMMLDLFFF MFLLSIWVVAYGVAKQGILIENEERLNWIIRGAVYEPYIT IFGNFPTNIDNTLFDISSCSVNASDPLKPKCPMLNADNTP VFPEWLTIMMLCVYLLFANILLLNLLIAIFNYTFQEVQDN TDTIWKFQRYELIKEYHSRPALPPPFILLSHLILFIRGVF LRHKNFRQELEQTEEEELLSWEAYMKDNYLASTRQDESQS VEHRIHDTAEKVGAMSELLEREQEMVXXXXXXXXXXXXXX XXXXXXXXDEEAPHMFARQLQYPDSTVRRFPVPEEKVSWE VNFSPYQPPVYNQKHRNPGGRTGIRGKGALNTLGPNHILH PIFTRWRDKVLEFLAVWRWALLGGPALAQVLERILGKKLN EGEEVYKGYVDDSRNTDNAWVETSIITLHCDKNTMADLNH MVELQWREVSSDACRCSYQREALRQIA B:  LASWIKENIKKKEQWDKHRHVRETPTDAFGDISFGGLGQK TGKYVRVSSDTSCENLYQLMTEQWKLRSPNLLISVTGGAK NFYIKTHLKDKFRRGLIKVAQTTGAWILTGGTHAGVMKHV GMAVRDYTLSSGSMEGQIVVIGVAPWGVIHNRSTLIHPEG RFPAYYSLDEQGQGRLSCLDINHTHFLLVDDGTQGHYGVE IELRARLEKLISKLSLGGVTIPVVCVVLDGGPGTLNTIYN SMLNHTPCVVLEGSGRLADVIAHVASVPVSKVTMALINRL LKRFFMQEYKNFTELQIIEWTKKIQDILRMPHLLTVFRID EDKNYDVDVAILQALLKASRSDEHAGRHCWERQLELAVAW NRVDIAESEIFTEESQWTSSDLHPAMFSALVGDKPEFVRL LLENGVCVREFLEREETLCELYSHLPSCFFLRKLAKRVQE PLPGSRKVCLSHVSEEVRHLLGSFTQPLYIASRYDTVWDP GRDLFLWAVVQNNRELAEIGWEQCRDCIAAALAASKILRK LAQESGEDDSEEATEMLELANHYEKQAIGVFSECHSWDAQ RAQKLLIRISPSWGRSTCLWLALEAHDKSFIAHSGVQALL TQIWCGELSVDNPHWKVLLCMIFFPLIYTGFLTFRRDEDI QRQAERTEQQKNCSSRLMSFLKSPQVKFYWNIASYFGFLW LFAVVLMIDFQTSPSWRELLLYVWLTSLVCEEIRQLYHDG FRRKAKMYIKDLWNILDVLSIVLFIAGLICRLQASDTVFY IGKVILCIDFIIFCLRLMAIFSISRTLGPKIIIVRRMMLD LFFFMFLLSIWVVAYGVAKQGILIENEERLNWIIRGAVYE PYITIFGNFPTNIDNTLFDISSCSVNASDPLKPKCPMLNA DNTPVFPEWLTIMMLCVYLLFANILLLNLLIAIFNYTFQE VQDNTDTIWKFQRYELIKEYHSRPALPPPFILLSHLILFI RGVFLRHKNFRQELEQTEEEELLSWEAYMKDNYLASTRQD ESQSVEHRIHDTAEKVGAMSELLEREQEMVXXXXXXXXXX XXXXXXXXXXXXEEAPHMFARQLQYPDSTVRRFPVPEEKV SWEVNFSPYQPPVYNQQDKHRNPGGRTGIRGKGALNTLGP NHILHPIFTRWRDAEHKVLEFLAVWEDAEKRWALLGGPAQ PDLAQVLERILGKKLKTLLKAGEEVYKGYVDDSRNTDNAW VETSIITLHTPLMADLNHMVESSLSSHQPLQWREVSSDAC RCSYQREALRQIAHHH C:  LASWIKENIKKKEWDKHRHVRETPTDAFGDISFGGLGQKT GKYVRVSSDTSCENLYQLMTEQWKLRSPNLLISVTGGAKN FYIKTHLKDKFRRGLIKVAQTTGAWILTGGTHAGVMKHVG MAVRDYTLSSGSMEGQIVVIGVAPWGVIHNRSTLIHPEGR FPAYYSLDEQGQGRLSCLDINHTHFLLVDDGTQGHYGVEI ELRARLEKLISKLSLGNRESGVTIPVVCVVLDGGPGTLNT IYNSMLNHTPCVVLEGSGRLADVIAHVASVPVSKVTMALI NRLLKRFFMQEYKNFTELQIIEWTKKIQDILRMPHLLTVF RIDEDKNYDVDVAILQALLKASRSDEHAGRHCWERQLELA VAWNRVDIAESEIFTEESQWTSSDLHPAMFSALVGDKPEF VRLLLENGVCVREFLEREETLCELYSHLPSCFFLRKLAKR VQCLSHVSEEVRHLLGSFTQPLYIASRYKDTVWDPGRDLF LWAVVQNNRELAEIGWEQCRDCIAAALAASKILRKLAQES GEDDSEEATEMLELANHYEKQAIGVFSECHSWDAQRAQKL LIRISPSWGRSTCLWLALEAHDKSFIAHSGVQALLTQIWC GELSVDNPHWKVLLCMIFFPLIYTGFLTFRRDEDIQRQAE RTEQCSSRLMSFLKSPQVKFYWNIASYFGFLWLFAVVLMI DFQTSPSWRELLLYVWLTSLVCEEIRQLYHDFDGSGFRRK AKMYIKDLWNILDVLSIVLFIAGLICRLQASDTVFYIGKV ILCIDFIIFCLRLMAIFSISRTLGPKIIIVRRMMLDLFFF MFLLSIWVVAYGVAKQGILIENEERLNWIIRGAVYEPYIT IFGNFPTNIDNTLFDISSCSVNASDPLKPKCPMLNADNTP VFPEWLTIMMLCVYLLFANILLLNLLIAIFNYTFQEVQDN TDTIWKFQRYELIKEYHSRPALPPPFILLSHLILFIRGVF LRHKNFRQELEQTEEEELLSWEAYMKDNYLASTRQDESQS VEHRIHDTAEKVGAMSELLEREQEMVXXXXXXXXXXXXXX XXXXXXXXDEEAPHMFARQLQYPDSTVRRFPVPEEKVSWE VNFSPYQPPVYNQKHRNPGGRTGIRGKGALNTLGPNHILH PIFTRWRDKVLEFLAVWRWALLGGPALAQVLERILGKKLN EGEEVYKGYVDDSRNTDNAWVETSIITLHCDKNTMADLNH MVELQWREVSSDACRCSYQREALRQIA D:  LASWIKENIKKKEQWDKHRHVRETPTDAFGDISFGGLGQK TGKYVRVSSDTSCENLYQLMTEQWKLRSPNLLISVTGGAK NFYIKTHLKDKFRRGLIKVAQTTGAWILTGGTHAGVMKHV GMAVRDYTLSSGSMEGQIVVIGVAPWGVIHNRSTLIHPEG RFPAYYSLDEQGQGRLSCLDINHTHFLLVDDGTQGHYGVE IELRARLEKLISKLSLGGVTIPVVCVVLDGGPGTLNTIYN SMLNHTPCVVLEGSGRLADVIAHVASVPVSKVTMALINRL LKRFFMQEYKNFTELQIIEWTKKIQDILRMPHLLTVFRID EDKNYDVDVAILQALLKASRSDEHAGRHCWERQLELAVAW NRVDIAESEIFTEESQWTSSDLHPAMFSALVGDKPEFVRL LLENGVCVREFLEREETLCELYSHLPSCFFLRKLAKRVQE PLPGSRKVCLSHVSEEVRHLLGSFTQPLYIASRYDTVWDP GRDLFLWAVVQNNRELAEIGWEQCRDCIAAALAASKILRK LAQESGEDDSEEATEMLELANHYEKQAIGVFSECHSWDAQ RAQKLLIRISPSWGRSTCLWLALEAHDKSFIAHSGVQALL TQIWCGELSVDNPHWKVLLCMIFFPLIYTGFLTFRRDEDI QRQAERTEQQKNCSSRLMSFLKSPQVKFYWNIASYFGFLW LFAVVLMIDFQTSPSWRELLLYVWLTSLVCEEIRQLYHDG FRRKAKMYIKDLWNILDVLSIVLFIAGLICRLQASDTVFY IGKVILCIDFIIFCLRLMAIFSISRTLGPKIIIVRRMMLD LFFFMFLLSIWVVAYGVAKQGILIENEERLNWIIRGAVYE PYITIFGNFPTNIDNTLFDISSCSVNASDPLKPKCPMLNA DNTPVFPEWLTIMMLCVYLLFANILLLNLLIAIFNYTFQE VQDNTDTIWKFQRYELIKEYHSRPALPPPFILLSHLILFI RGVFLRHKNFRQELEQTEEEELLSWEAYMKDNYLASTRQD ESQSVEHRIHDTAEKVGAMSELLEREQEMVXXXXXXXXXX XXXXXXXXXXXXEEAPHMFARQLQYPDSTVRRFPVPEEKV SWEVNFSPYQPPVYNQQDKHRNPGGRTGIRGKGALNTLGP NHILHPIFTRWRDAEHKVLEFLAVWEDAEKRWALLGGPAQ PDLAQVLERILGKKLKTLLKAGEEVYKGYVDDSRNTDNAW VETSIITLHTPLMADLNHMVESSLSSHQPLQWREVSSDAC RCSYQREALRQIAHHH Description (1)  Transient receptor potential cation channel subfamily M member 8 Functional site 1) chain B residue 857 type sequence E description binding site for residue CA B 1601 source : AC1 2) chain B residue 860 type sequence Q description binding site for residue CA B 1601 source : AC1 3) chain B residue 883 type sequence N description binding site for residue CA B 1601 source : AC1 4) chain B residue 886 type sequence D description binding site for residue CA B 1601 source : AC1 5) chain B residue 925 type sequence R description binding site for residue CA B 1601 source : AC1 6) chain A residue 857 type sequence E description binding site for residue CA A 1601 source : AC2 7) chain A residue 860 type sequence Q description binding site for residue CA A 1601 source : AC2 8) chain A residue 883 type sequence N description binding site for residue CA A 1601 source : AC2 9) chain A residue 925 type sequence R description binding site for residue CA A 1601 source : AC2 10) chain C residue 857 type sequence E description binding site for residue CA C 1601 source : AC3 11) chain C residue 860 type sequence Q description binding site for residue CA C 1601 source : AC3 12) chain C residue 883 type sequence N description binding site for residue CA C 1601 source : AC3 13) chain C residue 925 type sequence R description binding site for residue CA C 1601 source : AC3 14) chain D residue 857 type sequence E description binding site for residue CA D 1601 source : AC4 15) chain D residue 860 type sequence Q description binding site for residue CA D 1601 source : AC4 16) chain D residue 883 type sequence N description binding site for residue CA D 1601 source : AC4 17) chain D residue 886 type sequence D description binding site for residue CA D 1601 source : AC4 18) chain D residue 925 type sequence R description binding site for residue CA D 1601 source : AC4

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