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eF-site ID
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6d73-C |
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PDB Code
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6d73 |
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Chain
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C |
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click to enlarge
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Title
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Cryo-EM structure of the zebrafish TRPM2 channel in the presence of Ca2+ |
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Classification
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TRANSPORT PROTEIN |
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Compound
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Transient receptor potential cation channel, subfamily M |
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Source
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(6D73) |
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Sequence
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C: |
LASWIKENIKKKEWDKHRHVRETPTDAFGDISFGGLGQKT
GKYVRVSSDTSCENLYQLMTEQWKLRSPNLLISVTGGAKN
FYIKTHLKDKFRRGLIKVAQTTGAWILTGGTHAGVMKHVG
MAVRDYTLSSGSMEGQIVVIGVAPWGVIHNRSTLIHPEGR
FPAYYSLDEQGQGRLSCLDINHTHFLLVDDGTQGHYGVEI
ELRARLEKLISKLSLGNRESGVTIPVVCVVLDGGPGTLNT
IYNSMLNHTPCVVLEGSGRLADVIAHVASVPVSKVTMALI
NRLLKRFFMQEYKNFTELQIIEWTKKIQDILRMPHLLTVF
RIDEDKNYDVDVAILQALLKASRSDEHAGRHCWERQLELA
VAWNRVDIAESEIFTEESQWTSSDLHPAMFSALVGDKPEF
VRLLLENGVCVREFLEREETLCELYSHLPSCFFLRKLAKR
VQCLSHVSEEVRHLLGSFTQPLYIASRYKDTVWDPGRDLF
LWAVVQNNRELAEIGWEQCRDCIAAALAASKILRKLAQES
GEDDSEEATEMLELANHYEKQAIGVFSECHSWDAQRAQKL
LIRISPSWGRSTCLWLALEAHDKSFIAHSGVQALLTQIWC
GELSVDNPHWKVLLCMIFFPLIYTGFLTFRRDEDIQRQAE
RTEQCSSRLMSFLKSPQVKFYWNIASYFGFLWLFAVVLMI
DFQTSPSWRELLLYVWLTSLVCEEIRQLYHDFDGSGFRRK
AKMYIKDLWNILDVLSIVLFIAGLICRLQASDTVFYIGKV
ILCIDFIIFCLRLMAIFSISRTLGPKIIIVRRMMLDLFFF
MFLLSIWVVAYGVAKQGILIENEERLNWIIRGAVYEPYIT
IFGNFPTNIDNTLFDISSCSVNASDPLKPKCPMLNADNTP
VFPEWLTIMMLCVYLLFANILLLNLLIAIFNYTFQEVQDN
TDTIWKFQRYELIKEYHSRPALPPPFILLSHLILFIRGVF
LRHKNFRQELEQTEEEELLSWEAYMKDNYLASTRQDESQS
VEHRIHDTAEKVGAMSELLEREQEMVXXXXXXXXXXXXXX
XXXXXXXXDEEAPHMFARQLQYPDSTVRRFPVPEEKVSWE
VNFSPYQPPVYNQKHRNPGGRTGIRGKGALNTLGPNHILH
PIFTRWRDKVLEFLAVWRWALLGGPALAQVLERILGKKLN
EGEEVYKGYVDDSRNTDNAWVETSIITLHCDKNTMADLNH
MVELQWREVSSDACRCSYQREALRQIA
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Description
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(1) |
Transient receptor potential cation channel subfamily M member 8
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Functional site
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|
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1)
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chain |
C |
| residue |
857 |
| type |
|
| sequence |
E
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| description |
binding site for residue CA C 1601
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| source |
: AC3
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2)
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chain |
C |
| residue |
860 |
| type |
|
| sequence |
Q
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| description |
binding site for residue CA C 1601
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| source |
: AC3
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|
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3)
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chain |
C |
| residue |
883 |
| type |
|
| sequence |
N
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| description |
binding site for residue CA C 1601
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| source |
: AC3
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|
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4)
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chain |
C |
| residue |
925 |
| type |
|
| sequence |
R
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| description |
binding site for residue CA C 1601
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| source |
: AC3
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