eF-site ID 6d5v-S PDB Code 6d5v Chain S click to enlarge Title Ras:SOS:Ras in complex with a small molecule activator Classification SIGNALING PROTEIN Compound GTPase HRas Source (SOS1_HUMAN) Sequence S:  QMRLPSADVYRFAEPDSEENIIFEEGIPIIKAGTVIKLIE RLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIP EPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLN VCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVE SITKIIQRKKIANITFQSSPPTVEWHISRPGHIETFDLLT LHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINS PNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEI LQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQK KILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNIL KTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQP YCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEP RNPKPLPRFPKKYSYPLKSPGVRPSNP Description Functional site 1) chain S residue 852 type sequence V description binding site for residue FVY S 1101 source : AC3 2) chain S residue 878 type sequence M description binding site for residue FVY S 1101 source : AC3 3) chain S residue 879 type sequence N description binding site for residue FVY S 1101 source : AC3 4) chain S residue 883 type sequence V description binding site for residue FVY S 1101 source : AC3 5) chain S residue 884 type sequence Y description binding site for residue FVY S 1101 source : AC3 6) chain S residue 886 type sequence L description binding site for residue FVY S 1101 source : AC3 7) chain S residue 889 type sequence T description binding site for residue FVY S 1101 source : AC3 8) chain S residue 890 type sequence F description binding site for residue FVY S 1101 source : AC3 9) chain S residue 893 type sequence I description binding site for residue FVY S 1101 source : AC3 10) chain S residue 901 type sequence L description binding site for residue FVY S 1101 source : AC3 11) chain S residue 902 type sequence E description binding site for residue FVY S 1101 source : AC3 12) chain S residue 905 type sequence H description binding site for residue FVY S 1101 source : AC3 13) chain S residue 927-960 type prosite sequence VPFFGIYLTNILKTEEGNPEVLKRHGKELINFSK description RASGEF Ras Guanine-nucleotide exchange factors domain signature. VPFfGiyLtNIlkteegnpevlkrhgkel.................INFsK source prosite : PS00720

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