eF-site ID 6d5k-ABC PDB Code 6d5k Chain A, B, C click to enlarge Title Structure of Human ATP:Cobalamin Adenosyltransferase bound to ATP, and Adenosylcobalamin Classification TRANSFERASE Compound Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial Source (MMAB_HUMAN) Sequence A:  DDQVFEAVGTTDELSSAIGFALELVTEKGHTFAEELQKIQ CTLQDVGSALATKYTTFKAGPILELEQWIDKYTSQLPPLT AFILPSGGKISSALHFCRAVCRRAERRVVPLVQMGETDAN VAKFLNRLSDYLFTLARYAAMKEGNQEKIYMK B:  KIYTKTGDKGFSSTFTGERRPKDDQVFEAVGTTDELSSAI GFALELVTEKGHTFAEELQKIQCTLQDVGSALATPCSSAR EAHLKYTTFKAGPILELEQWIDKYTSQLPPLTAFILPSGG KISSALHFCRAVCRRAERRVVPLVQMGETDANVAKFLNRL SDYLFTLARYAAMKEGNQEKIY C:  DKGFSSTFTGERRPKDDQVFEAVGTTDELSSAIGFALELV TEKGHTFAEELQKIQCTLQDVGSALATPCSSAREAHLKYT TFKAGPILELEQWIDKYTSQLPPLTAFILPSGGKISSALH FCRAVCRRAERRVVPLVQMGETDANVAKFLNRLSDYLFTL ARYAAMKEGNQEKIYMKN Description Functional site 1) chain A residue 190 type sequence R description binding site for residue 5AD A 301 source : AC1 2) chain A residue 193 type sequence E description binding site for residue 5AD A 301 source : AC1 3) chain A residue 194 type sequence R description binding site for residue 5AD A 301 source : AC1 4) chain C residue 68 type sequence S description binding site for residue 5AD A 301 source : AC1 5) chain C residue 69 type sequence S description binding site for residue 5AD A 301 source : AC1 6) chain C residue 78 type sequence K description binding site for residue 5AD A 301 source : AC1 7) chain C residue 83 type sequence F description binding site for residue 5AD A 301 source : AC1 8) chain A residue 168 type sequence T description binding site for residue B12 A 302 source : AC2 9) chain A residue 169 type sequence A description binding site for residue B12 A 302 source : AC2 10) chain A residue 170 type sequence F description binding site for residue B12 A 302 source : AC2 11) chain A residue 171 type sequence I description binding site for residue B12 A 302 source : AC2 12) chain A residue 186 type sequence R description binding site for residue B12 A 302 source : AC2 13) chain A residue 190 type sequence R description binding site for residue B12 A 302 source : AC2 14) chain A residue 217 type sequence S description binding site for residue B12 A 302 source : AC2 15) chain A residue 218 type sequence D description binding site for residue B12 A 302 source : AC2 16) chain A residue 221 type sequence F description binding site for residue B12 A 302 source : AC2 17) chain A residue 239 type sequence M description binding site for residue B12 A 302 source : AC2 18) chain C residue 71 type sequence F description binding site for residue B12 A 302 source : AC2 19) chain C residue 86 type sequence V description binding site for residue B12 A 302 source : AC2 20) chain C residue 90 type sequence D description binding site for residue B12 A 302 source : AC2 21) chain C residue 122 type sequence Q description binding site for residue B12 A 302 source : AC2 22) chain C residue 126 type sequence S description binding site for residue B12 A 302 source : AC2 23) chain C residue 129 type sequence A description binding site for residue B12 A 302 source : AC2 24) chain A residue 86 type sequence V description binding site for residue B12 A 303 source : AC3 25) chain A residue 90 type sequence D description binding site for residue B12 A 303 source : AC3 26) chain A residue 122 type sequence Q description binding site for residue B12 A 303 source : AC3 27) chain A residue 126 type sequence S description binding site for residue B12 A 303 source : AC3 28) chain B residue 57 type sequence K description binding site for residue B12 A 303 source : AC3 29) chain B residue 167 type sequence L description binding site for residue B12 A 303 source : AC3 30) chain B residue 168 type sequence T description binding site for residue B12 A 303 source : AC3 31) chain B residue 170 type sequence F description binding site for residue B12 A 303 source : AC3 32) chain B residue 171 type sequence I description binding site for residue B12 A 303 source : AC3 33) chain B residue 186 type sequence R description binding site for residue B12 A 303 source : AC3 34) chain B residue 190 type sequence R description binding site for residue B12 A 303 source : AC3 35) chain B residue 217 type sequence S description binding site for residue B12 A 303 source : AC3 36) chain B residue 221 type sequence F description binding site for residue B12 A 303 source : AC3 37) chain A residue 108 type sequence H description binding site for residue SO4 A 304 source : AC4 38) chain A residue 109 type sequence T description binding site for residue SO4 A 304 source : AC4 39) chain A residue 110 type sequence F description binding site for residue SO4 A 304 source : AC4 40) chain A residue 226 type sequence Y description binding site for residue SO4 A 304 source : AC4 41) chain A residue 83 type sequence F description binding site for residue 5AD B 301 source : AC5 42) chain B residue 190 type sequence R description binding site for residue 5AD B 301 source : AC5 43) chain B residue 193 type sequence E description binding site for residue 5AD B 301 source : AC5 44) chain B residue 194 type sequence R description binding site for residue 5AD B 301 source : AC5 45) chain B residue 108 type sequence H description binding site for residue SO4 B 302 source : AC6 46) chain B residue 109 type sequence T description binding site for residue SO4 B 302 source : AC6 47) chain B residue 110 type sequence F description binding site for residue SO4 B 302 source : AC6 48) chain B residue 226 type sequence Y description binding site for residue SO4 B 302 source : AC6 49) chain B residue 211 type sequence K description binding site for residue SO4 B 303 source : AC7 50) chain C residue 141 type sequence K description binding site for residue SO4 B 303 source : AC7 51) chain C residue 142 type sequence Y description binding site for residue SO4 B 303 source : AC7 52) chain B residue 60 type sequence T description binding site for residue ATP C 301 source : AC8 53) chain B residue 61 type sequence K description binding site for residue ATP C 301 source : AC8 54) chain B residue 62 type sequence T description binding site for residue ATP C 301 source : AC8 55) chain B residue 63 type sequence G description binding site for residue ATP C 301 source : AC8 56) chain B residue 68 type sequence S description binding site for residue ATP C 301 source : AC8 57) chain B residue 69 type sequence S description binding site for residue ATP C 301 source : AC8 58) chain B residue 78 type sequence K description binding site for residue ATP C 301 source : AC8 59) chain B residue 83 type sequence F description binding site for residue ATP C 301 source : AC8 60) chain C residue 190 type sequence R description binding site for residue ATP C 301 source : AC8 61) chain C residue 193 type sequence E description binding site for residue ATP C 301 source : AC8 62) chain C residue 194 type sequence R description binding site for residue ATP C 301 source : AC8 63) chain C residue 214 type sequence N description binding site for residue ATP C 301 source : AC8 64) chain B residue 58 type sequence I description binding site for residue MG C 302 source : AC9 65) chain C residue 218 type sequence D description binding site for residue MG C 302 source : AC9 66) chain A residue 214 type sequence N description binding site for residue EPE C 303 source : AD1 67) chain A residue 218 type sequence D description binding site for residue EPE C 303 source : AD1 68) chain C residue 68 type sequence S description binding site for residue EPE C 303 source : AD1 69) chain C residue 69 type sequence S description binding site for residue EPE C 303 source : AD1 70) chain C residue 75 type sequence R description binding site for residue EPE C 303 source : AD1 71) chain C residue 108 type sequence H description binding site for residue SO4 C 304 source : AD2 72) chain C residue 109 type sequence T description binding site for residue SO4 C 304 source : AD2 73) chain C residue 110 type sequence F description binding site for residue SO4 C 304 source : AD2 74) chain C residue 226 type sequence Y description binding site for residue SO4 C 304 source : AD2 75) chain C residue 230 type sequence K description binding site for residue SO4 C 304 source : AD2 76) chain C residue 147 type sequence A description binding site for residue SO4 C 305 source : AD3 77) chain C residue 208 type sequence N description binding site for residue SO4 C 305 source : AD3 78) chain C residue 214 type sequence N description binding site for residue MG C 306 source : AD4 79) chain B residue 214 type BINDING sequence N description BINDING => ECO:0000269|PubMed:17176040 source Swiss-Prot : SWS_FT_FI1 80) chain C residue 68 type BINDING sequence S description BINDING => ECO:0000269|PubMed:17176040 source Swiss-Prot : SWS_FT_FI1 81) chain C residue 78 type BINDING sequence K description BINDING => ECO:0000269|PubMed:17176040 source Swiss-Prot : SWS_FT_FI1 82) chain C residue 190 type BINDING sequence R description BINDING => ECO:0000269|PubMed:17176040 source Swiss-Prot : SWS_FT_FI1 83) chain C residue 214 type BINDING sequence N description BINDING => ECO:0000269|PubMed:17176040 source Swiss-Prot : SWS_FT_FI1 84) chain A residue 190 type BINDING sequence R description BINDING => ECO:0000269|PubMed:17176040 source Swiss-Prot : SWS_FT_FI1 85) chain A residue 214 type BINDING sequence N description BINDING => ECO:0000269|PubMed:17176040 source Swiss-Prot : SWS_FT_FI1 86) chain B residue 60 type BINDING sequence T description BINDING => ECO:0000269|PubMed:17176040 source Swiss-Prot : SWS_FT_FI1 87) chain B residue 68 type BINDING sequence S description BINDING => ECO:0000269|PubMed:17176040 source Swiss-Prot : SWS_FT_FI1 88) chain B residue 78 type BINDING sequence K description BINDING => ECO:0000269|PubMed:17176040 source Swiss-Prot : SWS_FT_FI1 89) chain B residue 190 type BINDING sequence R description BINDING => ECO:0000269|PubMed:17176040 source Swiss-Prot : SWS_FT_FI1 90) chain B residue 134 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI2 91) chain C residue 134 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI2 92) chain B residue 211 type MOD_RES sequence K description N6-succinyllysine => ECO:0000250|UniProtKB:Q9D273 source Swiss-Prot : SWS_FT_FI3 93) chain C residue 211 type MOD_RES sequence K description N6-succinyllysine => ECO:0000250|UniProtKB:Q9D273 source Swiss-Prot : SWS_FT_FI3 94) chain A residue 211 type MOD_RES sequence K description N6-succinyllysine => ECO:0000250|UniProtKB:Q9D273 source Swiss-Prot : SWS_FT_FI3 95) chain B residue 230 type MOD_RES sequence K description N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q9D273 source Swiss-Prot : SWS_FT_FI4 96) chain C residue 230 type MOD_RES sequence K description N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q9D273 source Swiss-Prot : SWS_FT_FI4 97) chain A residue 230 type MOD_RES sequence K description N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q9D273 source Swiss-Prot : SWS_FT_FI4

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