|
|
eF-site ID
|
6d2p-H |
|
PDB Code
|
6d2p |
|
Chain
|
H |
|
click to enlarge
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Title
|
Crystal structure of IOMA-class CLK31 Fab from an HIV-1 naive donor in complex with a germline-targeting gp120 engineered outer domain eOD-GT8 at 2.6 A |
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Classification
|
IMMUNE SYSTEM |
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Compound
|
Germline-targeting HIV-1 gp120 engineered outer domain eOD-GT8 |
|
Source
|
(6D2P) |
|
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Sequence
|
H: |
QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYMHWVRQA
PGQGLEWMGWINPNSGGTNYAQKFQGRVTMTRDTSISTAY
MELSRLRSDDTAVYYCARSLGRDWFDPWGQGTLVTVSSAS
TKGPSVFPLAPSTAALGCLVKDYFPEPVTVSWNSGALTSG
VHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKP
SNTKVDKKVEPKS
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Description
|
|
Functional site
|
|
|
1)
|
chain |
H |
| residue |
10 |
| type |
|
| sequence |
E
|
| description |
binding site for residue GOL H 301
|
| source |
: AC4
|
|
|
2)
|
chain |
H |
| residue |
19 |
| type |
|
| sequence |
K
|
| description |
binding site for residue GOL H 301
|
| source |
: AC4
|
|
|
3)
|
chain |
H |
| residue |
33 |
| type |
|
| sequence |
Y
|
| description |
binding site for residue GOL H 302
|
| source |
: AC5
|
|
|
4)
|
chain |
H |
| residue |
99 |
| type |
|
| sequence |
S
|
| description |
binding site for residue GOL H 302
|
| source |
: AC5
|
|
|
5)
|
chain |
H |
| residue |
101 |
| type |
|
| sequence |
G
|
| description |
binding site for residue GOL H 302
|
| source |
: AC5
|
|
|
6)
|
chain |
H |
| residue |
199-205 |
| type |
prosite |
| sequence |
YICNVNH
|
| description |
IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH
|
| source |
prosite : PS00290
|
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|